Japanese Organization for Medical Device Development Inc. and Toho University | Date: 2017-01-25
A template 13 which comprises a cusp base forming part 11 having a shape corresponding to a cusp base is provided to obtain cusp material for dispersing stresses exerted on the cusp. Such a cusp forming template may further comprise wing forming parts 15 corresponding to wing parts provided outside the cusp base forming part 11. As examples of the wing forming part, there may be employed a single or plural holes provided at a part or parts corresponding to the outline of each wing, and guide parts provided at parts corresponding to the outline of wings.
Deng T.-B.,Toho University
IEEE Transactions on Circuits and Systems I: Regular Papers | Year: 2011
This paper presents a closed-form method for minimizing the weighted squared error of variable fractional-delay (VFD) of an all-pass VFD digital filter under an equality constraint on its normalized root-mean-squared (NRMS) error of variable frequency response (VFR). The main purpose is to reduce the squared VFD error as much as possible while keeping its NRMS VFR error exactly at a predetermined value. We first prove that the linearized VFR error of an all-pass VFD filter is almost the same as its linearized phase error, and then convert the equality-constrained weighted-least-squares (WLS) design into an unconstrained optimization problem through the minimization of a mixed error function that mixes the weighted squared VFD error and squared VFR error. To reduce the computational complexity, we derive a closed-form mixed error function by utilizing Taylor series expansions of trigonometric functions. Therefore, the error functions can be efficiently computed without discretizing the design parameters (frequency ω and VFD parameter ρ). The closed-form mixed error function not only reduces the computational complexity, but also speeds up the design process as well guarantees the optimality of the final solution. Furthermore, a two-point search (dichotomous search) scheme is proposed for finding the optimal range ρ ∈ [ρMin, ρMax] of the VFD parameter ρ, and then the subfilter orders are optimized under a given filter complexity constraint (the number of all-pass VFD filter coefficients). This two-stage optimization process utilizes the NRMS VFD error as an error criterion. Design examples and comparisons are given to demonstrate that the closed-form mixed WLS method yields low-complexity all-pass VFD filters with a high-accuracy VFD response but without noticeably degrading its frequency response. © 2011 IEEE.
Deng T.-B.,Toho University
IEEE Transactions on Circuits and Systems I: Regular Papers | Year: 2011
This paper presents a simple linear programming (LP) technique for designing high-accuracy low-complexity finite-impulse-response (FIR) variable fractional-delay (VFD) digital filters in the minimax error sense. The objective of the minimax design is to minimize the maximum absolute error of the variable frequency response (VFR) of an FIR VFD filter, which is a nonlinear problem and difficult to solve. This paper shows that the minimax design can be approximately decomposed into a pair of separate LP subproblems by decoupling the minimization of the real-part VFR error from that of the imaginary-part error. As a result, the original nonlinear minimax design problem can be easily solved by solving the two LP subproblems separately. To reduce the VFD filter complexity, we also propose a one-by-one increase scheme for optimizing the subfilter orders in the Farrow structure such that a given design specification (maximum absolute error of VFR) can be exactly satisfied. Both even-order and odd-order design examples are given to illustrate that the decoupling minimax method is not only simple, but also can achieve excellent high-accuracy low-complexity FIR VFD filters. © 2011 IEEE.
Komatsu H.,Toho University
World Journal of Gastroenterology | Year: 2014
Hepatitis B (HB) virus (HBV) infection, which causes liver cirrhosis and hepatocellular carcinoma, is endemic worldwide. Hepatitis B vaccines became commercially available in the 1980s. The World Health Organization recommended the integration of the HB vaccine into the national immunisation programs in all countries. HBV prevention strategies are classified into three groups: (1) universal vaccination alone; (2) universal vaccination with screening of pregnant women plus HB immune globulin (HBIG) at birth; and (3) selective vaccination with screening of pregnant women plus HBIG at birth. Most low-income countries have adopted universal vaccine programs without screening of pregnant women. However, HB vaccines are not widely used in low-income countries. The Global Alliance for Vaccine and Immunization was launched in 2000, and by 2012, the global coverage of a three-dose HB vaccine had increased to 79%. The next challenges are to further increase the coverage rate, close the gap between recommendations and routine practices, approach high-risk individuals, screen and treat chronically infected individuals, and prevent breakthrough infections. To eradicate HBV infections, strenuous efforts are required to overcome socioeconomic barriers to the HB vaccine; this task is expected to take several decades to complete. © 2014 Baishideng Publishing Group Inc. All rights reserved.
Kishimoto T.,Toho University
PLoS genetics | Year: 2010
It remains to be determined experimentally whether increasing fitness is related to positive selection, while stationary fitness is related to neutral evolution. Long-term laboratory evolution in Escherichia coli was performed under conditions of thermal stress under defined laboratory conditions. The complete cell growth data showed common continuous fitness recovery to every 2°C or 4°C stepwise temperature upshift, finally resulting in an evolved E. coli strain with an improved upper temperature limit as high as 45.9°C after 523 days of serial transfer, equivalent to 7,560 generations, in minimal medium. Two-phase fitness dynamics, a rapid growth recovery phase followed by a gradual increasing growth phase, was clearly observed at diverse temperatures throughout the entire evolutionary process. Whole-genome sequence analysis revealed the transition from positive to neutral in mutation fixation, accompanied with a considerable escalation of spontaneous substitution rate in the late fitness recovery phase. It suggested that continually increasing fitness not always resulted in the reduction of genetic diversity due to the sequential takeovers by fit mutants, but caused the accumulation of a considerable number of mutations that facilitated the neutral evolution.
Toho University | Date: 2014-03-05
An atrial fibrillation inhibitor, including: a compound expressed by one of the following Structural Formulas (I) to (VI) or a pharmacologically acceptable salt thereof, wherein the atrial fibrillation inhibitor inhibits atrial fibrillation:
Toho University | Date: 2014-03-28
A cardiac massage practice device including a simulated heart, a simulated vein, a simulated artery, and a mannequin of an upper half of a human body, wherein the simulated heart contracts from a stationary state to be deformable to a contracted state, and dilates from the stationary state to be deformable to a dilated state, wherein the simulated vein is coupled to the simulated heart, and when the simulated heart dilates from the contracted state, transfers virtual blood to an inside of the simulated heart, wherein the simulated artery is coupled to the simulated heart, and when the simulated heart contracts from the dilated state, transfers the virtual blood transferred to the inside of the simulated heart from the inside of the simulated heart to an outside of the simulated heart, and wherein the mannequin of the upper half of the human body houses the simulated heart therein.
Toho University | Date: 2014-02-25
An objective of the present invention is to provide a caged compound that can be photoactivated selectively for specific target cell types and can be used in an individual organism. The objective can be achieved by a compound represented by general formula K-Q-X, which is prepared by binding bioactive substance X, photocleavable protecting group Q, and compound K, which can be an enzyme substrate and is dissociated from Q-X by an enzyme reaction, wherein: Q is a protecting group that is photocleaved by light with a specific wavelength and then dissociated from X, when K is not bound thereto; X is a substance that does not express bioactivity when Q is bound thereto, but expresses bioactivity when Q is dissociated therefrom; and K is dissociated from Q by the above enzyme, so as to form a compound represented by Q-X. Specifically, the objective can be achieved with the use of such a compound, which is characterized in that Q is dissociated from X when the compound represented by Q-X is photoirradiated, and thus K expresses bioactivity.
Toho University and Hitachi High-Technologies | Date: 2014-02-19
An object of the present invention is to enable simpler operation in real time and culture while removing unnecessary cells from cultured cells for purification in analyzing, fractionating, and culturing the cells alive and to analyze and fractionate desired cells from the cultured cells to increase the purity, recovery rate, and viability of the cells. The present invention employs a cell-adhesive photocontrollable base material, wherein light irradiation causes the bond dissociation of a photolabile group comprising a coumarinylmethyl skeleton to produce the separation of a cell-adhesive material to leave a non-cell-adhesive material. As a result, cell images can be detected and analyzed to obtain the positional information of desired cells. Based on the positional information thus obtained, the cells can be analyzed and fractionated alive.
Toho University | Date: 2013-09-09
A method for allowing an animal to develop atrioventricular block, the method including: administering an immune regulator targeting a sphingosine-1-phosphate receptor to an animal selected from a pig, a monkey and a guinea pig.