Tnmc And Byl Nair Ch Hospital

Mumbai, India

Tnmc And Byl Nair Ch Hospital

Mumbai, India
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Rathi P.M.,Tnmc And Byl Nair Ch Hospital | Zanwar V.G.,Tnmc And Byl Nair Ch Hospital
Journal of Association of Physicians of India | Year: 2016

There has been increasing interest in the entity “Non-celiac gluten sensitivity” in recent years which was first of its in 1980s. This “rediscovered” disorder is characterized by intestinal and extra-intestinal symptoms which occur after ingestion of gluten containing food. The number of such patients who neither have celiac disease nor wheat allergy, but appear to benefit from gluten withdrawal is increasing substantially. However it still remains a controversial and its pathogenesis is not well understood. Lack of biomarkers is a major limitation making it difficult to differentiate it from other gluten related disorders. Recent studies have raised the possibility that, beside gluten and wheat amylasetrypsin inhibitors (ATI), low-fermentable, poorly-absorbed, short-chain carbohydrates can contribute to symptoms (at least those related to IBS) experienced by NCGS patients. In this paper we will focus on the manifestations of NCGS and evidence for the condition. Also areas of controversy, major advances and future trends will be discussed. © 2016, Journal of Association of Physicians of India. All Rights reserved.


Lad S.K.,Tnmc And Byl Nair Ch Hospital | Amonkar G.,Tnmc And Byl Nair Ch Hospital
Cardiovascular Pathology | Year: 2015

Tuberculous involvement of the heart though not common has been reported in literature. Pericardium is commonly involved followed by the myocardium. Endocardial involvement is rare. We would like to report a case of a 14-year-old female with florid and extensive involvement of all the layers of the heart by tuberculosis. © 2015.


Londhey V.,TNMC and BYL Nair Ch Hospital | Shah M.M.,TNMC and BYL Nair Ch Hospital
Journal of Association of Physicians of India | Year: 2016

Introduction: Anti-cyclic citrullinated peptide (anti-CCP) antibodies have been considered very specific for rheumatoid arthritis (RA). Some studies have shown that these antibodies can be positive in infectious diseases like TB, HIV, etc. Methods: Fifty patients of tuberculosis both pulmonary and extrapulmonary were enrolled in the study from inpatient and outpatient departments from May 2012 to November 2013. Anti-CCP antibody test was done in all the patient by ELISA. Results: Thirty one were pulmonary and 17 were extra-pulmonary and two were disseminated extra-pulmonary TB. Of the 31 cases of pulmonary tuberculosis, 12 cases (38.7%) were positive for anti-CCP antibodies and 19 cases (61.3%) were negative for same. Of the 19 cases of extrapulmonary tuberculosis, two cases (10.52%) were positive for anti-CCP antibodies and 17 cases (89.48%) were negative. Of the 31 patients of pulmonary TB, nine were sputum positive and 22 were negative. Of those with sputum positive five (55.56%) were positive for anti-CCP antibodies and those with sputum negative 7 cases (31.81%) were positive for anti-CCP antibodies. Conclusion: Anti-CCP can be falsely positive in cases of tuberculosis. Positivity of anti-CCP antibodies for tuberculosis is more for pulmonary (more for sputum-positive than sputum-negative) than extra-pulmonary TB. Anti-CCP thus is not very specific for rheumatoid arthritis. © 2016, Journal of Association of Physicians of India. All rights reserved.


Londhey V.,TNMC and BYL Nair Ch Hospital | Londhey V.,Seven Hills Hospital | Limaye C.,TNMC and BYL Nair Ch Hospital
Journal of Association of Physicians of India | Year: 2015

Introduction: The Ethics Committees (EC) are established to safeguard the safety and rights of the subjects participating in a research study. No formal training about Ethics Committee is given to the medical students in undergraduate and post graduate education as a part of curriculum. Aims and Objectives: To study the awareness about the composition and functioning of EC amongst the medical teachers. Methodology: A prevalidated questionnaire was given to the medical teachers who consented to participate in the study, fill up the questionnaire immediately and return it. The questions consisted of knowledge about the composition of the EC and its functioning in general. Results: Ninety two (51%) belonged to non-clinical branches; 88(49%) were clinicians. Forty (22%) had undergone ICH-GCP training (27 belong to clinical and 13 non-clinical branches). Forty four point four percent were well informed about the composition of EC in general. The most common wrong answer was “Dean” is the Chairperson of EC. Conclusions: As the years of experience as Faculty in Nair increased, the knowledge about the composition of EC’s in general increased but the information about functioning of IEC did not improve significantly. The awareness about EC was significantly higher amongst the PG teachers. © 2015, Journal of The Association of Physicians of India. All rights reserved.


PubMed | Tnmc And Byl Nair Ch Hospital
Type: Journal Article | Journal: International journal of applied & basic medical research | Year: 2014

Neuroleptic malignant syndrome (NMS) is a rare, but fatal condition characterized by rigidity, fever, dysautonomia and altered consciousness along with elevated serum creatinine phosphokinase levels and leukocytosis. Treatment of NMS includes symptomatic and specific treatment with drugs like bromocriptine may be given. Risk factors for NMS include dehydration, parenteral antipsychotics and high potency antipsychotics. One of the important, but lesser known risk factors for NMS is low serum iron. Pronounced reduction in serum iron suggests that acute phase reactants do have a role in NMS. The present case report focuses on the importance of low serum iron as a risk factor for NMS.


PubMed | Tnmc And Byl Nair Ch Hospital
Type: Journal Article | Journal: Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology | Year: 2016

Tuberculous involvement of the heart though not common has been reported in literature. Pericardium is commonly involved followed by the myocardium. Endocardial involvement is rare. We would like to report a case of a 14-year-old female with florid and extensive involvement of all the layers of the heart by tuberculosis.


PubMed | Tnmc And Byl Nair Ch Hospital
Type: Journal Article | Journal: Vascular and endovascular surgery | Year: 2016

Arterial pseudoaneurysms are relatively rare complications of the vascular system. Many cases may remain asymptomatic for a lifetime only to be discovered incidentally, whereas others may cause fatal hemorrhage. Majority of cases present with local compressive symptoms. Rarely, it has been implicated as an etiology for gastrointestinal (GI) bleed by eroding into an adjacent bowel, with splanchnic pseudoaneurysm being more commonly responsible as compared to peripheral ones. Although rare, they are an important consideration because of the high mortality rate. They require a high index of suspicion with prompt diagnosis and expedient treatment, either surgical or endovascular. In this study, we report a case series of a right iliacoduodenal and 2 splanchnic pseudoaneurysms presenting as upper GI bleeding. These 3 cases presented with occult source of hematemesis due to the formation of arterioenteric fistula. Also discussed are the diagnostic approach used and successful treatment methods, which included placing endoprosthesis in the aorta and common iliac artery and endovascular coiling for respective cases. To the best of our knowledge, such a case of common iliac pseudoaneurysm presenting with massive hematemesis due to fistulization into duodenum has never been reported previously.


PubMed | Tilak Ayurved Mahavidyalaya and Tnmc And Byl Nair Ch Hospital
Type: Journal Article | Journal: Ancient science of life | Year: 2014

Attention Deficit Hyperactivity Disorder (ADHD) is characterized by a persistent pattern of inattention and/or hyperactivity-impulsivity. In view of the adverse effects associated with psycho-stimulants used for the treatment of this disorder, efficacy of Brhm ghtam was evaluated in this condition.After following due ethical considerations, children of either sex between the age group of 6 and 12 years diagnosed to be suffering from mixed variety of ADHD as per The Diagnostic and Statistical Manual of Mental Disorders (DSM) IV criteria irrespective of other co-morbid psychiatric illnesses were recruited in the study. Initially a pilot study (n = 10) was carried out to confirm the efficacy of the identified dose of Brhm ghtam. Using this dose, further therapeutic confirmatory study (n = 27) was carried out, wherein Brhm ghtam was compared with methylphenidate. Effect on ADHD symptoms was assessed using the Dupaul ADHD rating scale and this was the main efficacy parameter.In the pilot exploratory study, Brhm ghtam showed 66% decrease in total ADHD score. In the therapeutic confirmatory study, only 16% improvement was seen with Brhm ghtam, which was similar to methylphenidate, standard treatment for ADHD that was used as a comparator in the present study. No side-effects were reported in both studies.Our study thus has adequately demonstrated efficacy and safety of Brhm ghtam in ADHD.


PubMed | TNMC and BYL Nair Ch Hospital and Ex Resident.
Type: Journal Article | Journal: The Journal of the Association of Physicians of India | Year: 2016

Anti-cyclic citrullinated peptide (anti-CCP) antibodies have been considered very specific for rheumatoid arthritis (RA). Some studies have shown that these antibodies can be positive in infectious diseases like TB, HIV, etc.Fifty patients of tuberculosis both pulmonary and extra-pulmonary were enrolled in the study from inpatient and outpatient departments from May 2012 to November 2013. Anti-CCP antibody test was done in all the patient by ELISA.Thirty one were pulmonary and 17 were extra-pulmonary and two were disseminated extra-pulmonary TB. Of the 31 cases of pulmonary tuberculosis, 12 cases (38.7%) were positive for anti-CCP antibodies and 19 cases (61.3%) were negative for same. Of the 19 cases of extra-pulmonary tuberculosis, two cases (10.52%) were positive for anti-CCP antibodies and 17 cases (89.48%) were negative. Of the 31 patients of pulmonary TB, nine were sputum positive and 22 were negative. Of those with sputum positive five (55.56%) were positive for anti-CCP antibodies and those with sputum negative 7 cases (31.81%) were positive for anti-CCP antibodies.Anti-CCP can be falsely positive in cases of tuberculosis. Positivity of anti-CCP antibodies for tuberculosis is more for pulmonary (more for sputum-positive than sputum-negative) than extra-pulmonary TB. Anti-CCP thus is not very specific for rheumatoid arthritis.


PubMed | Tnmc And Byl Nair Ch Hospital
Type: Journal Article | Journal: Journal of anaesthesiology, clinical pharmacology | Year: 2013

Thrombocytopenia in pregnancy carries a major risk of feto-maternal morbidity and mortality. We present a case of hypocellular bone marrow with severe thrombocytopenia with pregnancy induced hypertension (PIH) for emergency lower segment cesarean section (LSCS). This disease is characterized by pancytopenia and hypocellular bone marrow with impaired morphology and maturation. Causes of death due to this disease include hemorrhage and infection secondary to thrombocytopenia and neutropenia especially following surgery. We report successful management of emergency LSCS with severe thrombocytopenia with severe PIH.

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