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Ghodke D.G.,TNMC and BYL Nair Ch. Hospital
Medico-Legal Update | Year: 2013

Carbon monoxide poisoning is an important aspect of most fires - indeed it is the major or even sole cause of death in many victims of conflagrations, especially in house fire. When any combustible material burns in air, most of the carbon in organic material, such as timber, fabric and furnishings, is converted to carbon dioxide. Carbon monoxide is also produced, however, and, where the access of oxygen is limited or exhausted by the ongoing combustion, larger volumes of the carbon monoxide are produced. Slow, smouldering fires with little flame are likely to produce more monoxide, as with burning bedclothes and mattresses. Here one case of burn is discussed, where thirty five year old person was found dead in his closed room. On crime scene visit it was found that only mattress is burnt, rest of the room is normal. On examination the deceased was sustained only 18% superficial burns. The samples were preserved for chemical analysis. Chemical analysis of blood reveals 46% carboxyl haemoglobin.

Lad S.K.,TNMC and BYL Nair Ch. Hospital | Amonkar G.,TNMC and BYL Nair Ch. Hospital
Cardiovascular Pathology | Year: 2015

Tuberculous involvement of the heart though not common has been reported in literature. Pericardium is commonly involved followed by the myocardium. Endocardial involvement is rare. We would like to report a case of a 14-year-old female with florid and extensive involvement of all the layers of the heart by tuberculosis. © 2015.

Rathi P.M.,TNMC and BYL Nair Ch. Hospital | Zanwar V.G.,TNMC and BYL Nair Ch. Hospital
Journal of Association of Physicians of India | Year: 2016

There has been increasing interest in the entity “Non-celiac gluten sensitivity” in recent years which was first of its in 1980s. This “rediscovered” disorder is characterized by intestinal and extra-intestinal symptoms which occur after ingestion of gluten containing food. The number of such patients who neither have celiac disease nor wheat allergy, but appear to benefit from gluten withdrawal is increasing substantially. However it still remains a controversial and its pathogenesis is not well understood. Lack of biomarkers is a major limitation making it difficult to differentiate it from other gluten related disorders. Recent studies have raised the possibility that, beside gluten and wheat amylasetrypsin inhibitors (ATI), low-fermentable, poorly-absorbed, short-chain carbohydrates can contribute to symptoms (at least those related to IBS) experienced by NCGS patients. In this paper we will focus on the manifestations of NCGS and evidence for the condition. Also areas of controversy, major advances and future trends will be discussed. © 2016, Journal of Association of Physicians of India. All Rights reserved.

Londhey V.,TNMC and BYL Nair Ch. Hospital | Shah M.M.,TNMC and BYL Nair Ch. Hospital
Journal of Association of Physicians of India | Year: 2016

Introduction: Anti-cyclic citrullinated peptide (anti-CCP) antibodies have been considered very specific for rheumatoid arthritis (RA). Some studies have shown that these antibodies can be positive in infectious diseases like TB, HIV, etc. Methods: Fifty patients of tuberculosis both pulmonary and extrapulmonary were enrolled in the study from inpatient and outpatient departments from May 2012 to November 2013. Anti-CCP antibody test was done in all the patient by ELISA. Results: Thirty one were pulmonary and 17 were extra-pulmonary and two were disseminated extra-pulmonary TB. Of the 31 cases of pulmonary tuberculosis, 12 cases (38.7%) were positive for anti-CCP antibodies and 19 cases (61.3%) were negative for same. Of the 19 cases of extrapulmonary tuberculosis, two cases (10.52%) were positive for anti-CCP antibodies and 17 cases (89.48%) were negative. Of the 31 patients of pulmonary TB, nine were sputum positive and 22 were negative. Of those with sputum positive five (55.56%) were positive for anti-CCP antibodies and those with sputum negative 7 cases (31.81%) were positive for anti-CCP antibodies. Conclusion: Anti-CCP can be falsely positive in cases of tuberculosis. Positivity of anti-CCP antibodies for tuberculosis is more for pulmonary (more for sputum-positive than sputum-negative) than extra-pulmonary TB. Anti-CCP thus is not very specific for rheumatoid arthritis. © 2016, Journal of Association of Physicians of India. All rights reserved.

Londhey V.,TNMC and BYL Nair Ch. Hospital | Limaye C.,TNMC and BYL Nair Ch. Hospital
Journal of Association of Physicians of India | Year: 2015

Introduction: The Ethics Committees (EC) are established to safeguard the safety and rights of the subjects participating in a research study. No formal training about Ethics Committee is given to the medical students in undergraduate and post graduate education as a part of curriculum. Aims and Objectives: To study the awareness about the composition and functioning of EC amongst the medical teachers. Methodology: A prevalidated questionnaire was given to the medical teachers who consented to participate in the study, fill up the questionnaire immediately and return it. The questions consisted of knowledge about the composition of the EC and its functioning in general. Results: Ninety two (51%) belonged to non-clinical branches; 88(49%) were clinicians. Forty (22%) had undergone ICH-GCP training (27 belong to clinical and 13 non-clinical branches). Forty four point four percent were well informed about the composition of EC in general. The most common wrong answer was “Dean” is the Chairperson of EC. Conclusions: As the years of experience as Faculty in Nair increased, the knowledge about the composition of EC’s in general increased but the information about functioning of IEC did not improve significantly. The awareness about EC was significantly higher amongst the PG teachers. © 2015, Journal of The Association of Physicians of India. All rights reserved.

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