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Bavdekar S.B.,TN Medical College and BYL Nair Charitable Hospital | Gogtay N.J.,Seth Gs Medical College And Kem Hospital
Journal of Association of Physicians of India | Year: 2015

Abstract is a vital part of a research paper. Besides the title, it is the most widely read section of an article. The first impressions created by the abstract on editors and reviewers can have a great influence on the fate of the article. After its publication, a reader might decide to give the article a miss, if he finds the information provided in the abstract uninteresting, irrelevant or uninspiring. An abstract should, therefore, be packed with all important relevant information about the study, so that reviewers and readers understand the rationale of the study, are assured of adequacy of the methodology employed, are informed about the important findings and appreciate the reasonable conclusions stated in the abstract. Brevity, self-sufficiency, providing complete and accurate information in an unbiased manner are some of the important characteristics of a good abstract. © 2015, Journal of Association of Physicians of India. All rights reserved.

Kuyare M.S.,In charge | Taur S.R.,TN Medical College and BYL Nair Charitable Hospital | Thatte U.M.,Seth Gs Medical College And Kem Hospital
Indian journal of medical ethics | Year: 2014

This review of the literature was conducted to identify the challenges faced while establishing institutional ethics committees (IECs) as well as to suggest some solutions. The search of the literature was carried out with the help of the PubMed search engine, using “research ethics committees” (MeSH] and “India” (MeSH]) as the key words for articles published between 2004 and 2012. We found 31 articles related to the topic, and the most common challenge mentioned was inappropriate functioning of IECs (n=17), followed by inappropriate structure (n=14). The authors identified many challenges related to the lack of oversight by regulatory bodies (n=14) as well as issues pertaining to the ethical training of IEC members and investigators (n=13). It is evident from the multitude of papers on the issue that the challenges related to the constitution and functioning of IECs must be given the attention they deserve to ensure that research participants in India are better protected.

Bavdekar S.B.,TN Medical College and BYL Nair Charitable Hospital
Journal of Association of Physicians of India | Year: 2015

The Introduction section explains the rationale for undertaking the study and clearly describes the main purpose of conducting it. It should be focused, succinct and crisp. Providing an extensive and detailed literature review, not stating the hypothesis of the objectives with clarity and not providing focused information are some of the common mistakes that the authors should steer clear of. © 2015 Journal of The Association of Physicians of India. All Rights Reserved.

Kalekar S.A.,TN Medical College and BYL Nair Charitable Hospital | Munshi R.P.,TN Medical College and BYL Nair Charitable Hospital | Thatte U.M.,Seth Gs Medical College And Kem Hospital
BMC Complementary and Alternative Medicine | Year: 2013

Background: Both experimental and clinical studies suggest that oxidative stress plays a major role in the pathogenesis of both types of diabetes mellitus. This oxidative stress leads to β-cell destruction by apoptosis. Hence exploring agents modulating oxidative stress is an effective strategy in the treatment of both Type I and Type II diabetes. Plants are a major source of anti-oxidants and exert protective effects against oxidative stress in biological systems. Phyllanthus emblica, Curcuma longa and Tinospora cordifolia are three such plants widely used in Ayurveda for their anti-hyperglycemic activity. Additionally their anti-oxidant properties have been scientifically validated in various experimental in vitro and in vivo models. Hence the present in vitro study was planned to assess whether the anti-hyperglycemic effects of the hydro-alcoholic extracts of Phyllanthus emblica (Pe) and Curcuma longa (Cl) and aqueous extract of Tinospora cordifolia (Tc) are mediated through their antioxidant and/or anti-apoptotic property in a streptozotocin induced stress model.Methods: RINm5F cell line was used as a model of pancreatic β-cells against stress induced by streptozotocin (2 mM). Non-toxic concentrations of the plant extracts were identified using MTT assay. Lipid peroxidation through MDA release, modulation of apoptosis and insulin release were the variables measured to assess streptozotocin induced damage and protection afforded by the plant extracts.Results: All 3 plants extracts significantly inhibited MDA release from RIN cells indicating protective effect against STZ induced oxidative damage. They also exhibited a dose dependent anti-apoptotic effect as seen by a decrease in the sub G0 population in response to STZ. None of the plant extracts affected insulin secretion from the cells to a great extent.Conclusion: The present study thus demonstrated that the protective effect of the selected medicinal plants against oxidative stress induced by STZ in vitro, which was exerted through their anti-oxidant and anti-apoptotic actions. © 2013 Kalekar et al.; licensee BioMed Central Ltd.

Writer H.S.,TN Medical College and BYL Nair Charitable Hospital | Arora R.D.,TN Medical College and BYL Nair Charitable Hospital
Otorhinolaryngology Clinics | Year: 2012

The approach in management of dizziness and disequilibrium is multidisciplinary. However, the emphasis is on function. Management models based on pathology alone may not provide the desired outcome as patients with similar pathologies will present with significant differences in impairments and functional limitations. Because of these differences, patients with similar pathologies may not respond the same to a given treatment. Both pathology and impairment information is essential for effective treatment planning. This article gives an overview of vestibular rehabilitation emphasizing on management models utilising treatment plans customized to individual patient's impairments. It briefly describes the anatomy and physiology of the motion sensors and its connections, explains the physiological basis of recovery from vestibular dysfunction and emphasizes the importance of history taking and examination to delineate impairments that cause activity limitation and participatory restrictions. Machine-based assessment may be used to quantify impairments. Use of equipments for rehabilitation shows good outcome but may not always be cost effective. Physiotherapists dealing with balance disorders are proficient in making a functional diagnosis to improve patient's balance and mobility tasks for safe and effective function in their daily life.

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