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Kuyare M.S.,Bhaktivedanta Hospital | Taur S.R.,TN Medical College and BYL Nair Charitable Hospital | Thatte U.M.,Seth GS Medical College and KEM Hospital
Indian journal of medical ethics | Year: 2014

This review of the literature was conducted to identify the challenges faced while establishing institutional ethics committees (IECs) as well as to suggest some solutions. The search of the literature was carried out with the help of the PubMed search engine, using “research ethics committees” (MeSH] and “India” (MeSH]) as the key words for articles published between 2004 and 2012. We found 31 articles related to the topic, and the most common challenge mentioned was inappropriate functioning of IECs (n=17), followed by inappropriate structure (n=14). The authors identified many challenges related to the lack of oversight by regulatory bodies (n=14) as well as issues pertaining to the ethical training of IEC members and investigators (n=13). It is evident from the multitude of papers on the issue that the challenges related to the constitution and functioning of IECs must be given the attention they deserve to ensure that research participants in India are better protected.


PubMed | TN Medical College and BYL Nair Charitable Hospital and University of Mumbai
Type: Journal Article | Journal: Indian journal of pharmacology | Year: 2016

The study was conducted to develop the glucocorticoid-induced osteoporosis (GIO) model in Sprague-Dawley weanling rats using different doses of methylprednisolone (MP) and evaluate the antiosteoporotic effect of a classical ayurvedic formulation, Panchatikta Ghrita (PG), in this model.Institutional Animal Ethics Committee approval was obtained. Development of model was done by subcutaneous injection of 2 doses of MP (14 and 28 mg/kg/week) for 4 weeks in 21-day old weanlings. Following confirmation of the dose of MP that induced osteoporosis, the antiosteoporotic effect of PG was tested in this model in comparison to a known antiosteoporotic agent, alendronate. Both alendronate (2.9 mg/kg/day) and PG (1.35 g/kg/day) were administered orally 2 weeks after MP - 14 mg/kg/week injection and continued for 4 weeks. Serum and urine calcium and inorganic phosphate were analyzed at weekly intervals. Animals were sacrificed after 6 weeks, and femur bones were processed to measure bone hardness and elasticity and for histological studies.Rats treated with MP - 14 mg/kg/week showed optimum osteoporotic effect with no mortality as compared to MP - 28 mg/kg/week; hence, this dose of MP was used further for the efficacy study. Osteoporotic rats treated with PG 1.35 g/kg showed increase in serum calcium and inorganic phosphate levels, whereas urine calcium and phosphate levels were significantly reduced. A significant decrease in a number of osteoclasts, whereas an increase in bone hardness and elasticity was observed as compared to diseased group demonstrating antiosteoporotic effect of PG.PG has an antiosteoporotic effect in GIO rat model.


Kalekar S.A.,TN Medical College and BYL Nair Charitable Hospital | Munshi R.P.,TN Medical College and BYL Nair Charitable Hospital | Thatte U.M.,Seth GS Medical College and KEM Hospital
BMC Complementary and Alternative Medicine | Year: 2013

Background: Both experimental and clinical studies suggest that oxidative stress plays a major role in the pathogenesis of both types of diabetes mellitus. This oxidative stress leads to β-cell destruction by apoptosis. Hence exploring agents modulating oxidative stress is an effective strategy in the treatment of both Type I and Type II diabetes. Plants are a major source of anti-oxidants and exert protective effects against oxidative stress in biological systems. Phyllanthus emblica, Curcuma longa and Tinospora cordifolia are three such plants widely used in Ayurveda for their anti-hyperglycemic activity. Additionally their anti-oxidant properties have been scientifically validated in various experimental in vitro and in vivo models. Hence the present in vitro study was planned to assess whether the anti-hyperglycemic effects of the hydro-alcoholic extracts of Phyllanthus emblica (Pe) and Curcuma longa (Cl) and aqueous extract of Tinospora cordifolia (Tc) are mediated through their antioxidant and/or anti-apoptotic property in a streptozotocin induced stress model.Methods: RINm5F cell line was used as a model of pancreatic β-cells against stress induced by streptozotocin (2 mM). Non-toxic concentrations of the plant extracts were identified using MTT assay. Lipid peroxidation through MDA release, modulation of apoptosis and insulin release were the variables measured to assess streptozotocin induced damage and protection afforded by the plant extracts.Results: All 3 plants extracts significantly inhibited MDA release from RIN cells indicating protective effect against STZ induced oxidative damage. They also exhibited a dose dependent anti-apoptotic effect as seen by a decrease in the sub G0 population in response to STZ. None of the plant extracts affected insulin secretion from the cells to a great extent.Conclusion: The present study thus demonstrated that the protective effect of the selected medicinal plants against oxidative stress induced by STZ in vitro, which was exerted through their anti-oxidant and anti-apoptotic actions. © 2013 Kalekar et al.; licensee BioMed Central Ltd.


Bavdekar S.B.,TN Medical College and BYL Nair Charitable Hospital | Gogtay N.J.,Seth GS Medical College and KEM Hospital
Journal of Association of Physicians of India | Year: 2015

Abstract is a vital part of a research paper. Besides the title, it is the most widely read section of an article. The first impressions created by the abstract on editors and reviewers can have a great influence on the fate of the article. After its publication, a reader might decide to give the article a miss, if he finds the information provided in the abstract uninteresting, irrelevant or uninspiring. An abstract should, therefore, be packed with all important relevant information about the study, so that reviewers and readers understand the rationale of the study, are assured of adequacy of the methodology employed, are informed about the important findings and appreciate the reasonable conclusions stated in the abstract. Brevity, self-sufficiency, providing complete and accurate information in an unbiased manner are some of the important characteristics of a good abstract. © 2015, Journal of Association of Physicians of India. All rights reserved.


Writer H.S.,TN Medical College and BYL Nair Charitable Hospital | Arora R.D.,TN Medical College and BYL Nair Charitable Hospital
Otorhinolaryngology Clinics | Year: 2012

The approach in management of dizziness and disequilibrium is multidisciplinary. However, the emphasis is on function. Management models based on pathology alone may not provide the desired outcome as patients with similar pathologies will present with significant differences in impairments and functional limitations. Because of these differences, patients with similar pathologies may not respond the same to a given treatment. Both pathology and impairment information is essential for effective treatment planning. This article gives an overview of vestibular rehabilitation emphasizing on management models utilising treatment plans customized to individual patient's impairments. It briefly describes the anatomy and physiology of the motion sensors and its connections, explains the physiological basis of recovery from vestibular dysfunction and emphasizes the importance of history taking and examination to delineate impairments that cause activity limitation and participatory restrictions. Machine-based assessment may be used to quantify impairments. Use of equipments for rehabilitation shows good outcome but may not always be cost effective. Physiotherapists dealing with balance disorders are proficient in making a functional diagnosis to improve patient's balance and mobility tasks for safe and effective function in their daily life.


Khattar V.S.,TN Medical College and BYL Nair Charitable Hospital | Hathiram B.T.,TN Medical College and BYL Nair Charitable Hospital | Kurup B.,TN Medical College and BYL Nair Charitable Hospital
Otorhinolaryngology Clinics | Year: 2011

Introduction: The complex anatomical relationships of the sinonasal compartment with the surrounding vital structures make it vulnerable, yet simultaneously surgically accessible. Sinonasal tumors, especially those extending beyond, toward the anterior skull base and orbit have always posed a challenge, as far as their en bloc, and when applicable, oncologically safe removal is concerned. Traditionally, numerous external approaches have been employed for their successful removal. With advancements in endoscopic sinus surgical techniques and instrumentation, a majority of these tumors can be removed via purely transnasal endoscopic, and sometimes endoscopic-assisted procedures. Materials and methods: A series of 61 sinonasal tumors have been managed by endoscopic or endoscopic-assisted procedures over the last 6 years. The principles of their management and the challenges posed have been highlighted. Methods to tackle the same, backed by evidence from numerous international studies have been applied to these, and the outcome discussed. Conclusion: Endoscopic and endoscopic-assisted procedures are proving to be an effective alternative to the traditional external approaches for the management of sinonasal malignancies with comparable results. However, a long-term meta-analysis is imperative to corroborate these results.


Bavdekar S.B.,TN Medical College and BYL Nair Charitable Hospital | Save S.,TN Medical College and BYL Nair Charitable Hospital
Journal of Association of Physicians of India | Year: 2015

Authors need to take the crucial decision of choosing the journal for their prospective manuscript before even starting to write it. Although, this choice is influenced by many factors, matching the intended recipients of the main message of the manuscript with a journal’s readership should override all other consideration in journal selection. That done, availability of time-bound review process, journal’s visibility, indexation in databases, regularity of publication, acceptance rate and expenses involved are some other factors that will help decide the choice. © 2015, Journal of Association of Physicians of India. All rights reserved.


Bavdekar S.B.,TN Medical College and BYL Nair Charitable Hospital
Journal of Association of Physicians of India | Year: 2015

The Introduction section explains the rationale for undertaking the study and clearly describes the main purpose of conducting it. It should be focused, succinct and crisp. Providing an extensive and detailed literature review, not stating the hypothesis of the objectives with clarity and not providing focused information are some of the common mistakes that the authors should steer clear of. © 2015 Journal of The Association of Physicians of India. All Rights Reserved.


PubMed | TN Medical College and BYL Nair Charitable Hospital
Type: | Journal: Case reports in pediatrics | Year: 2016

A forty-five-day-old female infant presented with prolonged jaundice with clinical features suggestive of congenital hypothyroidism (CHT). On investigations, the infant was noted to have indirect hyperbilirubinemia (13.8mg/dl) with increased levels of AST (298IU/dl) and ALT (174IU/dl) in the serum. The child had low levels of free T


PubMed | TN Medical College and BYL Nair Charitable Hospital
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016

Painful limping child is often considered due to septic arthritis. Iliopsoas abscess (IPA) is rare in adults and children. The aetiology is often related to tuberculosis of spine. Hereby we report a case of staphylococcal IPA where incidental evaluations led to obvious diagnosis of a rare primary immunodeficiency syndrome called Job syndrome or hyperimmunoglobulin E and Eosinophilia Syndrome (HIES). This was the first case of IPA in a case of immunodeficiency syndrome including HIES.

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