Bucharest, Romania

Titu Maiorescu University

Bucharest, Romania

The Universitatea Titu Maiorescu is a private university in Bucharest, Romania, founded in 1991. Wikipedia.

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Niculescu M.,Titu Maiorescu University
European review for medical and pharmacological sciences | Year: 2016

OBJECTIVE: The aim of the present study was to evaluate the anxiolytic properties of the new isoxazoline compounds BTG1640 and BTG1675A in comparison with diazepam.MATERIALS AND METHODS: We evaluated the ultrasonic distress emission in both sexes of neonatal rat pups (which seems to be a sensitive indicator of the rat emotional reactivity and represents a valuable tool to screen compounds with expected anxiolytic properties) and the locomotor activity in 30-day old rat pups.RESULTS: We found a significant reduction in the number of emitted ultrasonic calls only after i.p. administration of diazepam 1 mg/kg, while no significant reduction have been detected after i.p. administration of BTG 1640 and BTG 1675A. Furthermore, we found a significant reduction of locomotor activity in the first 10' of the test, only in the group treated with diazepam 0.1 mg.CONCLUSIONS: The tests validating the supposed anxiolytic properties of the new isoxazoline compounds BTG1640 and BTG1675A, in comparison with diazepam, gave negative results.

Transplant tolerance is an important issue in the clinical practice. Successful transplant depends on the ability to block the rejection of the transplanted organ. Currently, improving transplant tolerance is accomplished using immunosuppressive agents, but having also many toxic effects on the host body. So far, the conventional immunosuppressive therapy with calcineurin inhibitors such as cyclosporine or the newer tacrolimus, is the most common way to treat and prevent rejection; but, since the appearance of the fusion proteins, it became clear that the transplanted patients might have a chance for life-on-therapy but without the many toxic effects of the conventional immunosuppressive therapy. This new drug category - co-stimulation blockers - have the potential to eventually replace current therapies to become the new standard therapy of immunosuppression after organ transplantation.

Pirnau M.,Titu Maiorescu University
2015 International Conference on Speech Technology and Human-Computer Dialogue, SpeD 2015 | Year: 2015

In view of increasing resilience and improving mitigation of disaster situations in a specified region, a tool was proposed, built and tested for monitoring new posts and connections on a specified set of web sites. The tool aims to discover any new post on the specified site and to determine if it includes one or several keywords, or satisfies one of several logic conditions. The application is simple enough to run on any computer and can easily be transposed to run on mobile devices. The application is described and preliminary results presented and discussed. © 2015 IEEE.

Pirnau M.,Titu Maiorescu University
International Journal of Computers, Communications and Control | Year: 2010

There are several essential activities that need to take place in any service-oriented environment such as: a Web service has to be created, to have its interfaces and invocation methods defined, its service has to be published to one or more intranet or Internet repositories to locate potential users. A Web service needs to be located in order to invoke potential different users. The technologies offered by Web Services enable us to cast older applications, we can use them and the packages already existing in a certain enterprise. The infrastructure associated with older applications can also be wrapped as a serial set of services. In the following pages I tried to present general characteristics of the Web services up to present, as well as the usage of Java technologies for the implementation of web services. The present paper targets a systematisation of the main web services, as well as highlighting and testing the most important technologies used to develop them. © 2006-2010 by CCC Publications.

Cojocaru M.,Titu Maiorescu University
Romanian journal of internal medicine = Revue roumaine de médecine interne | Year: 2013

Rheumatoid arthritis (RA) is the most common chronic inflammatory joint disease. RA likely develops beginning with genetic risk. Investigating of preclinical period of RA will lead to understanding the relationships between genetic and environmental factors. The recent studies confirm the polygenic contribution of the major histocompatibility complex (MHC) to RA. Various genetic factors involved in the pathogenesis of RA have been discovered. HLA genes contribute only a portion of the genetic susceptibility to RA. There is also evidence for a contribution of non-class II genes to susceptibility. Non-HLA genes are also involved in disease pathogenesis, and identifying them remains a challenge. The association between RA and certain MHC alleles may be important in the pathogenesis of RA. In the future, research into genetic factors correlated with the severity of RA is expected to yield interesting and hopefully clinically relevant results. In this review we present the current data supporting the existence of susceptibility gene for RA.

Boriga R.,Titu Maiorescu University | Dascalescu A.C.,Titu Maiorescu University | Priescu I.,Titu Maiorescu University
Signal Processing: Image Communication | Year: 2014

Recently, the hyperchaotic maps have been investigated in order to develop more secure encryption schemes. In this paper we propose a new hyperchaotic map derived from parametric equations of the serpentine curve. Its complex behavior was proven theoretically and numerically, using Lyapunov exponents, bifurcation diagram and correlation dimension of the attractor. The proposed map is then used in a new image encryption scheme with a classic bi-modular architecture: a diffusion stage, in which the pixels of the plain image are shuffled using a random permutation generated with a new algorithm, and a confusion stage, in which the pixels are modified with a XOR-scheme based on the proposed map. The results of its statistical analysis show that the proposed image encryption scheme provides an efficient and secure way for image encryption. © 2014 Elsevier B.V.

Corina Ana B.,Titu Maiorescu University
International Multidisciplinary Scientific GeoConference Surveying Geology and Mining Ecology Management, SGEM | Year: 2013

The manager that applies Environmental Management System is the person designated by the management company to ensure environmental management, all activities that cause environmental policy, objectives and responsibilities. The environmental manager implement the environmental management system (EMS) using means such as: planning environmental objectives, supervision and control of implementation of environmental programs, improving the environmental performance of small and medium enterprises. © SGEM2013 All Rights Reserved by the International Multidisciplinary Scientific GeoConference SGEM.

Dascalescu A.C.,Titu Maiorescu University | Boriga R.E.,Titu Maiorescu University
Nonlinear Dynamics | Year: 2013

The good qualities of permutations with a high shift factor in terms of speech scrambling have been proven in the last 20 years. Nevertheless, the absence of a fast algorithm for generating them has limited their use in cryptographic applications. In this paper, we propose a new fast chaos-based method for generating random permutations with a high shift factor, and we compare it with some similar schemes, classical or chaos-based. The permutations generated by the proposed method have very few fixed points, too, making them theoretically suitable for image scrambling or for use as a diffusion stage in an image cryptosystem. We prove this fact using some standard indicators as MSE, UACI, NPCR, PCC, etc. and by comparisons to the results obtained for other algorithms of this type. All the results obtained are very good, including a speed of pixels permutation of 14 MB/s, allowing us to say that the proposed algorithm is a fast and efficient one, which can be used even in real-time scrambling. © 2013 Springer Science+Business Media Dordrecht.

Pirnau M.,Titu Maiorescu University
Proceedings of the 2015 7th International Conference on Electronics, Computers and Artificial Intelligence, ECAI 2015 | Year: 2015

There are hundreds of millions of searches performed through search engines daily. The increasing importance of search engines represents the end of the traditional outbound marketing strategy, now replaced with the reorientation of companies to inbound marketing strategies, presently a part of human existence. In the present electronic age the consumer has real time information available on all products, whether this information is obtained from search engines from specialized web pages, forums or other sources. This makes search engines essential, alongside with the website - containing the desired information on a favorable position with respect to other web sites - positioning. The paper presents a set of considerations regarding the state of the art and future of web crawling. © 2015 IEEE.

Tanasi C.M.,Titu Maiorescu University
Chirurgia (Bucharest, Romania : 1990) | Year: 2011

This case has multiple anatomical variants of the inferior vena cava and its branches which determine the appearance of associated arterial abnormalities. The study has been performed on a female corpse, aged average 60, with no other morphological changes of the blood vessels or retroperitoneal viscera. The method we used was classical dissection. We described a variant of the inferior vena cava formation and persistence of bilateral double renal arteries with changes of arterio-venous relations in the renal pedicles. We established correlations between the embryological development of the inferior vena cava and the renal vessels and we explained its appearance mechanisms. The peculiar aspect of the study is that anomalies in development of the inferior vena cava system have determined the disturbance of successive development of renal arteries during "ascensus renis" process. We consider important for the surgeon to have knowledge of possible anatomical variants of large retroperitoneal vessels in order to have a clear interpretation of the CT Angiography and Magnetic Resonance Angiography in such cases.

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