Yuan H.-Y.,Tieling Health College |
Qu X.-W.,Shenyang University
Journal of Dalian Medical University | Year: 2015
Objective: To investigate the incidence of liver toxicity and associated risks in patients receiving non - nucleoside reverse transcriptase inhibitors as highly active antiretroviral - therapy (HAART). Methods: A retrospective study was conducted from January, 2004 to December, 2010 on 102 patients with AIDS from Red Ribbon Outpatients in the First Affiliated Hospital of Chinese Medical University. We compared the levels of ALT\AST\GGT\TB and AP in patients before and after treatment, compared the liver toxicity incidence between NVP and EFV, and analyzed the risk of liver toxicity caused by treatment with non - nucleoside reverse transcriptase inhibitors. Results: Hepatotoxicity incidence was 35. 6% (26/73) in NVP - based HAART, and was 13. 8 % (4/31) in EFV - based HAART. Liver toxicity incidence of two treatment methods were significantly different (χ2 =4. 761, P =0. 029). By risk factor analysis, we found that different regimens, co-infection with HCV, baseline ALT elevations were independent risk factors of HAART treatment (P <0. 05). The most obvious change was GGT before and after therapy. Conclusion: Patients who receive HAART treatment containing NVP are more likely to have liver toxicity than patients who receive HAART treatment containing EFV. Different regimens, co - infection with HCV, baseline ALT elevations are independent risk factors of HAART.
Guan H.,No. 210 Hospital of PLA |
Guan H.,Dalian Medical University |
Piao F.,Dalian Medical University |
Zhang X.,Tieling Health College |
And 5 more authors.
Biological Trace Element Research | Year: 2012
To evaluate prenatal exposure to arsenic in the general population and its effects on birth size, we conducted a cross-sectional study in Dalian, China. Arsenic concentration in maternal and cord blood was detected by inductively coupled plasma-mass spectrometry and its effects on birth size were analyzed by multivariate analysis and multiple linear regression analysis. Arsenic concentrations in cord blood were significantly lower than those in maternal blood. A significant positive correlation was shown between maternal and cord blood arsenic concentrations. Maternal arsenic concentration was negatively associated with birth weight, height and chest circumference, and fetal arsenic concentration was negatively associated with head circumference. Our results indicate that arsenic exposure at environmental levels in uterus may pose adverse effects on fetal development. © 2012 Springer Science+Business Media, LLC.
Li F.,Wuhan University |
Fang M.,Tieling Health College |
Peng Y.,Tieling Health College |
Zhang J.,Wuhan University
Journal Wuhan University of Technology, Materials Science Edition | Year: 2015
The purpose of this study was to evaluate the antibacterial properties of experimental nano silver-containing cements (NSCs) using rat caries disease model. Nano silver base inorganic antibacterial powder was added to the reinforced glass ionomer cement at three different weight ratios to obtain a series of nano silver-containing cements, then two orthodontic cement products and three NSC samples were implanted into rat caries disease model, and their antibacterial properties were evaluated by the scanning electron microscope(SEM). Moreover, the rat caries disease model were established by inoculating cariogenic bacteria S mutans into antibiotics treated rat mouths and feeding with cariogenic diet. The tested materials were bonded on the surface of the buccal half crowns of the upper first premolar, and then fixed under the rats’front teeth lingual side to acquire enough retention. The SEM results indicated that the growth of streptococcus mutans was very active in group of Transbond XT. One month later, S mutans scattered on the GC Fuji ORTHO LC surface, and then the number significantly increased and arranged in chains after three months. In groups of NSC2, NSC3 and NSC4, the number of S mutans presented the downward trend and tended to disperse individually with the increase of silver nanoparticle content. We may conclude that the incorporation of silver nanoparticle enhanced GC Fuji ORTHO LC the adhesion restrain and killing effect to S mutans. © 2015, Wuhan University of Technology and Springer-Verlag Berlin Heidelberg.