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Mingji C.,Tibetan Traditional Medical College | Mingji C.,Austrian Academy of Sciences | Onakpoya I.J.,University of Oxford | Perera R.,University of Oxford | And 2 more authors.

Introduction: Hypertension is a leading cause of cardiovascular disease, which is the cause of one-third of global deaths and is a primary and rising contributor to the global disease burden. The objective of this systematic review was to determine the prevalence and awareness of hypertension among the inhabitants of Tibet and its association with altitude, using the data from published observational studies. Methods: We conducted electronic searches in Medline, Embase, ISI Web of Science and Global Health. No gender or language restrictions were imposed. We assessed the methodological characteristics of included studies using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) criteria. Two reviewers independently determined the eligibility of studies, assessed the methodology of included studies and extracted the data. We used meta-regression to estimate the degree of change in hypertension prevalence with increasing altitude. Results: We identified 22 eligible articles of which eight cross-sectional studies with a total of 16 913 participants were included. The prevalence of hypertension ranged between 23% and 56%. A scatter plot of altitude against overall prevalence revealed a statistically significant correlation (r=0.68; p=0.04). Meta-regression analysis revealed a 2% increase in the prevalence of hypertension with every 100 m increase in altitude (p=0.06). The locations and socioeconomic status of subjects affected the awareness and subsequent treatment and control of hypertension. Conclusions: The results from cross-sectional studies suggest that there is a significant correlation between altitude and the prevalence of hypertension among inhabitants of Tibet. The socioeconomic status of the inhabitants can influence awareness and management of hypertension. Very little research into hypertension has been conducted in other prefectures of Tibet where the altitude is much higher. Further research examining the impact of altitude on blood pressure is warranted. © 2015, BMJ Publishing Group. All rights reserved. Source

Ni L.,Shanghai University of Traditional Chinese Medicine | Zhao Z.,Shanghai University of Traditional Chinese Medicine | Xu H.,Shanghai University of Traditional Chinese Medicine | Chen S.,Chinese Institute of Materia Medica | Dorje G.,Tibetan Traditional Medical College

Endemic to the Sino-Himalayan subregion, the medicinal alpine plant Gentiana straminea is a threatened species. The genetic and molecular data about it is deficient. Here we report the complete chloroplast (cp) genome sequence of G. straminea, as the first sequenced member of the family Gentianaceae. The cp genome is 148,991. bp in length, including a large single copy (LSC) region of 81,240. bp, a small single copy (SSC) region of 17,085. bp and a pair of inverted repeats (IRs) of 25,333. bp. It contains 112 unique genes, including 78 protein-coding genes, 30 tRNAs and 4 rRNAs. The rps16 gene lacks exon2 between trnK-UUU and trnQ-UUG, which is the first rps16 pseudogene found in the nonparasitic plants of Asterids clade. Sequence analysis revealed the presence of 13 forward repeats, 13 palindrome repeats and 39 simple sequence repeats (SSRs). An entire cp genome comparison study of G. straminea and four other species in Gentianales was carried out. Phylogenetic analyses using maximum likelihood (ML) and maximum parsimony (MP) were performed based on 69 protein-coding genes from 36 species of Asterids. The results strongly supported the position of Gentianaceae as one member of the order Gentianales. The complete chloroplast genome sequence will provide intragenic information for its conservation and contribute to research on the genetic and phylogenetic analyses of Gentianales and Asterids. © 2015 Elsevier B.V. Source

Lu J.-N.,Shanghai University | Zhao Z.-L.,Shanghai University | Ni L.-H.,Shanghai University | Gaawe D.,Tibetan Traditional Medical College
Chinese Traditional and Herbal Drugs

Mitochondrion is one of the vital organelles in plants. Combined with chloroplast and nuclear genomes, mitochondrial DNA could be used to deduce the evolution of species more correctly. In this paper, we elaborated the characters of mitochondrial genome and reviewed the processes of identification of Chinese materia medica based on mitochondrial DNA sequences. © 2016, Editorial Office of Chinese Traditional and Herbal Drugs. All right reserved. Source

Dun Z.C.,Tibetan Traditional Medical College
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology

This study was aimed to investigate various factors influencing the proceduction of Cu(II) crossing human erythrocyte membrane, including concentration of Cu²⁺, pH value of the medium, temperature and time of incubation, and to derive kinetic equation of Cu(II) crossing human erythrocyte membrane. Suspension red blood cells were incubated by Cu²⁺, then content of Cu²⁺ crossed human erythrocyte membrane was determined by atomic absorption spectrometry under various conditions after digestion. The results showed that content of Cu²⁺ crossed human erythrocyte membrane increased with the increase of extracellular Cu²⁺ and enhancement of incubation temperature, and the content of Cu²⁺ crossed human erythrocyte membrane showed a increasing tendency when pH reached to 6.2-7.4, and to maximum at pH 7.4, then gradually decreased at range of pH 7.4-9.2. It is concluded that the Cu²⁺ crossing human erythrocyte has been confirmed to be the first order kinetics characteristics within 120 min, and the linear equation is 10³ × Y = 0.0497t +6.5992. Source

Zhang L.,Shanghai University of Traditional Chinese Medicine | Zhu T.,Shanghai University of Traditional Chinese Medicine | Qian F.,Shanghai University of Traditional Chinese Medicine | Xu J.,Shanghai University of Traditional Chinese Medicine | And 4 more authors.

Scrodentosides A-E (1-5), five new acylated iridoid glycosides, together with 19 known ones, were isolated from the whole plant of Scrophularia dentata Royle ex Benth. The structures of these isolated glycosides were elucidated by spectroscopic methods. Bioassay showed that compounds 7 and 11 had significant inhibitory effect against NF-κB activation with IC50 value of 43.7 μM and 1.02 μM respectively. © 2014 Elsevier B.V. Source

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