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Lan B.,Minzu University of China | Chen P.,Xian Medical University | Jiri M.,Minzu University of China | He N.,Minzu University of China | And 6 more authors.
Rheumatology International | Year: 2016

Current evidence suggests heredity and metabolic syndrome contributes to gout progression. Specifically, the WDR1 and CLNK genes may play a role in gout progression in European ancestry populations. However, no studies have focused on Chinese populations, especially Tibetan individuals. This study aims to determine whether variations in these two genes correlate with gout-related indices in Chinese-Tibetan gout patients. Eleven single-nucleotide polymorphisms in the WDR1 and CLNK genes were detected in 319 Chinese-Tibetan gout patients and 318 controls. We used one-way analysis of variance to evaluate the polymorphisms’ effects on gout based on mean serum levels of metabolism indicators, such as albumin, glucose (GLU), triglycerides, cholesterol, high-density lipoproteins (HDL-C), creatinine, and uric acid, from fasting venous blood samples. All p values were Bonferroni corrected. Polymorphisms of the WDR1 and CLNK genes affected multiple risk factors for gout development. Significant differences in serum GLU levels were detected between different genotypic groups with WDRI polymorphisms rs4604059 (p = 0.005) and rs12498927 (p = 0.005). In addition, significant differences in serum HDL-C levels were detected between different genotypic groups with the CLNK polymorphism rs2041215 (p = 0.001). Polymorphisms of CLNK also affected levels of albumin, triglycerides, and creatinine. This study is the first to investigate and identify positive correlations between WDR1 and CLNK gene polymorphisms in Chinese-Tibetan populations. Our findings provide significant evidence for the effect of genetic polymorphisms on gout-related factors in Chinese-Tibetan populations. © 2015, Springer-Verlag Berlin Heidelberg. Source


Ma Y.-M.,Sun Yat Sen University | Yang M.-J.,Tibet Vocational Technical College | Wang S.,Xiamen University | Li H.,Sun Yat Sen University | Peng X.-X.,Sun Yat Sen University
Fish and Shellfish Immunology | Year: 2015

Streptococcus iniae seriously affects the intensive farming of tilapias. Much work has been conducted on prevention and control of S. iniae infection, but little published information on the metabolic response is available in tilapias against the bacterial infection, and no metabolic modulation way may be adopted to control this disease. The present study used GC/MS based metabolomics to characterize the metabolic profiling of tilapias infected by a lethal dose (LD50) of S. iniae and determined two characteristic metabolomes separately responsible for the survival and dying fishes. A reversal changed metabolite, decreased and increased l-leucine in the dying and survival groups, respectively, was identified as a biomarker which featured the difference between the two metabolomes. More importantly, exogenous l-leucine could be used as a metabolic modulator to elevate survival ability of tilapias infected by S. iniae. These results indicate that tilapias mount metabolic strategies to deal with bacterial infection, which can be regulated by exogenous metabolites such as l-leucine. The present study establishes an alternative way, metabolic modulation, to cope with bacterial infections. © 2015 Elsevier Ltd. Source


Jiri M.,Minzu University of China | Zhang L.,Northwest University, China | Zhang L.,National Engineering Research Center for Miniaturized Detection Systems | Lan B.,Minzu University of China | And 7 more authors.
Clinical Rheumatology | Year: 2016

Gout is a common type of arthritis that is characterized by hyperuricemia, tophi, and joint inflammation. Current evidence suggests that heredity contributes to the progression of gout. Previous studies have shown that regulation of the ATP-binding cassette subfamily G member 2 (ABCG2) pathways plays a role in gout occurrence. To investigate and validate potential genetic associations with the risk of gout, we conducted a case–control study. We conducted 143 cases and 310 controls and genotyped seven single-nucleotide polymorphisms (SNPs) in ABCG2 gene. ABCG2 SNP association analyses were performed using SPSS 17.0 Statistical Package, PLINK Software, HaploView software package, and SHEsis software platform. We identified that four susceptibility SNPs were potentially associated with occurrence of gout. Rs2622621 and rs3114018 in ABCG2 can actually increase the risk of gout in log-additive model (rs2622621, odds ratio (OR) = 1.90, 95 % confidence interval (CI) 1.39–2.61, p < 0.001; rs3114018, OR = 1.55, 95 % CI 1.13–2.13, p = 0.006). We found that rs17731799G/T-G/G and rs3114020 T/C-T/T in ABCG2 can actually increase the risk of gout in dominant model (rs17731799, OR = 1.67, 95 % CI 1.05–2.66, p = 0.028; rs3114020, OR = 1.58, 95 % CI 1.00–2.51, p = 0.048). The ABCG2 haplotype “GGCTCTC” (OR = 0.46, 95 % CI 0.28–0.75, p = 0.0019) decreased the gout risk. Our results, combined with those from previous studies, suggest that genetic variation in ABCG2 may influence gout susceptibility in the Han population. © 2015, International League of Associations for Rheumatology (ILAR). Source


Xiao Y.J.,Tibet Vocational Technical College
Applied Mechanics and Materials | Year: 2014

Green Construction occupies an increasingly important position in the future construction of our country, but also the construction of an important direction of construction. Implement a, green construction and green construction management has a close relationship. I mainly green construction management problems in the analysis, put forward some suggestions and countermeasures on the basis of the hope that they carry out a comprehensive analysis of the construction works have some help. © (2014) Trans Tech Publications, Switzerland. Source


Dou X.J.,Tibet Vocational Technical College | Zhang Y.,Shenzhen University | Wu Y.H.,Shenzhen University
Toxicology and Environmental Health Sciences | Year: 2012

48 Balb/C mice were exposed to different concentrations of gaseity formaldehyde. The neurotoxicity of formaldehyde was revealed at six aspects including step-down test, passive avoidance test, glial fibrillary acidic protein (GFAP) immunohistochemistry, activity of superoxide dismulase (SOD), content of malondialdehyde (MDA) and cell gel electrophoresis technology (SCGE). In step-down test and passive avoidance test, the mice exposed to formaldehyde at high dose and moderate dose has made notable errors, compared with control group (P<0. 05). The GFAPpositive cells were increased with the increasing of doses. Activity of SOD and content of MDA were significant reduced after exposures at moderate dose and high dose (P<0. 05). Formaldehyde can also induce to DNA tail length, tail moments and tail DNA changes with the increased dose. The data suggested the necessity for a systematic observance of precautions in case of occupational and dwellingrelated formaldehyde exposure. © 2012 Korean Society of Environmental Risk Assessment and Health Science and Springer. Source

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