Tianjin University of Traditional Chinese Medicine is the name of a university in Tianjin, China under the municipal government. As the name implies, it specializes in traditional Chinese medicine. Wikipedia.
Xing M.-N.,Tianjin University |
Zhang X.-Z.,Tianjin University of Traditional Chinese Medicine |
Huang H.,Tianjin University
Biotechnology Advances | Year: 2012
Feedstock for biofuel synthesis is transitioning to lignocelluosic biomass to address criticism over competition between first generation biofuels and food production. As microbial catalysis is increasingly applied for the conversion of biomass to biofuels, increased import has been placed on the development of novel enzymes. With revolutionary advances in sequencer technology and metagenomic sequencing, mining enzymes from microbial communities for biofuel synthesis is becoming more and more practical. The present article highlights the latest research progress on the special characteristics of metagenomic sequencing, which has been a powerful tool for new enzyme discovery and gene functional analysis in the biomass energy field. Critical enzymes recently developed for the pretreatment and conversion of lignocellulosic materials are evaluated with respect to their activity and stability, with additional explorations into xylanase, laccase, amylase, chitinase, and lipolytic biocatalysts for other biomass feedstocks. © 2012 Elsevier Inc.
Wang K.,Shenyang Pharmaceutical University |
Qiu F.,Shenyang Pharmaceutical University |
Qiu F.,Tianjin University of Traditional Chinese Medicine
Current Drug Metabolism | Year: 2013
Curcuminoids are safe natural yellow pigments used as food coloring agents and traditional drugs with a variety of biological functions such as antitumor, anti-inflammatory and antioxidant activities. Poor oral bioavailability and the low plasma concentration of curcuminoids limited their clinical use, and one of the major reasons is their rapid metabolism in vivo. The predominant metabolic pathways are reduction and conjugation, and some drug metabolizing enzymes such as alcohol dehydrogenase, UDP-glucuronosyltransferases (UGTs) or sulfotransferases (SULTs) involved in the metabolic reactions. Besides the major metabolic pathways, dehydroxylation, cyclization and methylation can also occur in vivo. In addition, more than thirty metabolites of curcuminoids have been identified in biological matrices including the plasma, urine and bile from rats or humans by LC-MS/MS analysis and other methods. Some metabolites such as tetrahydro-curcuminoids have been reported to be active, which may explain how and why curcuminoids with poor oral bioavailability display their effectiveness in vivo. The present review mainly summarizes curcuminoid metabolism and its contribution to the pharmacological effects. © 2013 Bentham Science Publishers.
Yuan J.,Beijing University of Chemical Technology |
Hao C.,Tianjin University of Traditional Chinese Medicine
Solar Energy Materials and Solar Cells | Year: 2013
The reduction of CO2 into solar fuel is not only beneficial to the reduction of CO2 emission, but also beneficial to the release of energy shortage. In this study, a solar-driven photoelectrochemical reduction reaction of CO2 to methanol is conducted using a chalcopyrite p-CuInS2 thin film as a photocathode. The CuInS2 thin film is fabricated by electrodeposition of Cu-In alloy layer followed by sulfurization. With pyridinium ion as the co-catalyst, the photoelectrochemical reduction of CO2 to methanol can occur at the overpotential of 20 mV with the faradaic efficiency of 97%. © 2012 Elsevier B.V.
Tianjin University of Traditional Chinese Medicine | Date: 2010-10-14
Song C.,University of Florida |
Song C.,Tianjin University of Traditional Chinese Medicine |
Tong F.,University of Florida
Cytotherapy | Year: 2014
Background aims: Bone marrow-derived mesenchymal stromal cells (BMSCs) are being extensively investigated as cellular therapeutics for many diseases, including cardiovascular diseases. Although preclinical studies indicated that BMSC transplantation into infarcted hearts improved heart function, there are problems to be resolved, such as the low survival rate of BMSCs during the transplantation process and in the ischemic region with extreme oxidative stress. Autophagy plays pivotal roles in maintaining cellular homeostasis and defending against environmental stresses. However, the precise roles of autophagy in BMSCs under oxidative stress remain largely uncharacterized. Methods: BMSCs were treated with H2O2, and autophagic flux was examined by means of microtubule-associated protein 1A/1B-light chain 3 II/I ratio (LC3 II/I), autophagosome formation and p62 expression. Cytotoxicity and cell death assays were performed after co-treatment of BMSCs by autophagy inhibitor (3-methyladenine) or autophagy activator (rapamycin) together with H2O2. Results: We show that short exposure (1 h) of BMSCs to H2O2 dramatically elevates autophagic flux (2- to 4-fold), whereas 6-h prolonged oxidative treatment reduces autophagy but enhances caspase-3 and caspase-6-associated apoptosis. Furthermore, we show that pre- and co-treatment with rapamycin ameliorates H2O2-induced caspase-3 and caspase-6 activation and cell toxicity but that 3-methyladenine exacerbates H2O2-induced cell apoptotic cell death. Conclusions: Our results demonstrate that autophagy is critical for the survival of BMSCs under oxidative conditions. Importantly, we also suggest that the early induction of autophagic flux is possibly a self-defensive mechanism common in oxidant-tolerant cells. © 2014 International Society for Cellular Therapy.