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Tan S.,Tianjin University of Sport | Li W.,Tianjin University of Finance and Economy | Wang J.,University of Southern Queensland
Journal of Sports Science and Medicine | Year: 2012

This study evaluated the effects of a 6-month combined aerobic and resistance training program on the body composition, glycemic control, lipid profile, and functional capacity of older patients with a long history of type 2 diabetes. 25 subjects (65.9 ± 4.2 yrs; M/F: 13/12) with a long history of type 2 diabetes (16.7 ± 6.7 yrs) were randomly allocated into either the exercise or control groups. The exercise group trained three sessions a week. Each session consisted of a warm-up period, 30 minutes of moderate aerobic exercise, 10 minutes of resistance training with five leg muscle exercises (two sets of 10-12 repetitions at 50-70% of 1RM for each activity), and a cool-down period. The variables of body composition, glycemic control, lipid profile, and functional capacity were measured before and after the study period. Exercise training decreased waist-hip ratio and body fat of the trained subjects. Concentrations of fasting and 2- hour post-glucose challenge plasma glucose and serum insulin, and glycosylated hemoglobin decreased significantly in the exercise group. Exercise training improved the lipid profile and also increased the leg muscle strength and 6-minute walking distance of the trained subjects. The control group, however, increased their body fat and fasting plasma glucose, while other variables were not changed during the study period. The current results demonstrate that elderly patients with a long history of type 2 diabetes can benefit from the 6-month combined aerobic and resistance training program. © Journal of Sports Science and Medicine (2012).


Ji L.L.,University of Minnesota | Zhang Y.,Tianjin University of Sport
Free Radical Research | Year: 2014

Contraction-induced production of reactive oxygen species (ROS) has been implicated in oxidative stress to skeletal muscle for the past few decades. As research advances more evidence has revealed a more complete role of ROS under both physiological and pathological conditions. The current review postulated that moderate intensity of physical exercise has antioxidant and anti-inflammatory effects due to the operation and cross-talks of several redox-sensitive signal transduction pathways. The functional roles and mechanisms of action of the nuclear factor κB, mitogen-activated protein kinase, and peroxisome proliferator-activated receptor γ co-activator 1α are highlighted. © 2013 Informa UK, Ltd.


Xie H.,Karolinska Institutet | Zhao Y.,Karolinska Institutet | Zhao Y.,Tianjin University of Sport | Caramuta S.,Karolinska Institutet | And 2 more authors.
PLoS ONE | Year: 2012

MicroRNAs (miRNAs) are short non-coding RNA regulators that control gene expression mainly through post-transcriptional silencing. We previously identified miR-205 in a signature for human cervical cancer using a deep sequencing approach. In this study, we confirmed that miR-205 expression was frequently higher in human cervical cancer than their matched normal tissue samples. Functionally, we demonstrate that miR-205 promotes cell proliferation and migration in human cervical cancer cells. To further understand the biological roles of miR-205, we performed in vivo crosslinking and Argonaute 2 immunoprecipitation of miRNA ribonucleoprotein complexes followed by microarray analysis (CLIP-Chip) to identify its potential mRNA targets. Applying CLIP-Chip on gain- and loss-of-function experiments, we identified a set of transcripts as potential targets of miR-205. Several targets are functionally involved in cellular proliferation and migration. Two of them, CYR61 and CTGF, were further validated by Western blot analysis and quantification of mRNA enrichment in the Ago2 immunoprecipitates using qRT-PCR. Furthermore, both CYR61 and CTGF were downregulated in cervical cancer tissues. In summary, our findings reveal novel functional roles and targets of miR-205 in human cervical cancer, which may provide new insights about its role in cervical carcinogenesis and its potential value for clinical diagnosis. © 2012 Xie et al.


Wang Y.,Tianjin University of Sport | Watanabe K.,Institute of Sports and Health Science | Asaka T.,Hokkaido University
Journal of NeuroEngineering and Rehabilitation | Year: 2015

Background: To evaluate if multi-muscle synergies are comprised of flexible combinations of a small number of postural muscles to stabilize the center of pressure (COP) shift during preparation to making a step in the elderly (self-paced level stepping vs. obstacle crossing stepping). Methods: Electromyography (EMG) signals of leg and trunk muscles were recorded. Linear combination of integrated indices of muscle activity (M-modes) and their relationship to changes in the COP shift in the anterior-posterior (AP) direction were first determined. Uncontrolled manifold (UCM) analysis was performed to determine the extent to which variance of the M-modes acted to produce a consistent change in the COP displacement. Results: The elderly were capable of stabilizing the COPAP coordinate based on co-varied involvement of the M-modes. The synergy index (ΔV) changes in the elderly emerged later (100 ms prior to t0) and its magnitude was smaller as compared to that reported in younger persons. Conclusions: Our study reveals that aging is associated with a preserved ability to explore the flexibility of the M-mode compositions but a decrease ability to use multi-M-mode synergies following a predictable perturbation. © 2015 Wang et al.; licensee BioMed Central.


Wang Y.,Tianjin University of Sport | Watanabe K.,Institute of Sports and Health Science | Asaka T.,Hokkaido University
Research in Sports Medicine | Year: 2015

The aim of this article was to explore age-related differences in the muscle modes (M-modes) during voluntary body sway (VS). M-modes were defined as trunk and leg muscles organized into groups with parallel scaling of muscle activation level within a group. We hypothesized that, in comparison with young performers, older adults would show changes in the compositions of M-modes stabilizing the anterior-posterior (AP) center of pressure (COP) displacement. Young (27.5 ± 7.3 yr, 164.6 ± 9.7 cm and 58.4 ± 10.6 kg) and older (69.4 ± 6.4 yr, 160.0 ± 7.0 cm and 58.9 ± 7.5 kg) subjects performed the VS task in the AP direction while trying to minimize sway in the medio-lateral direction. EMG signals of 10 postural muscles were recorded and analyzed. Principal component analysis (PCA) was used to identify three M-modes within the space of integrated indices of muscle activity. The main findings were (1) that there were no age-related differences in magnitude of the COP displacement or amount of variance explained by the principal components (m-modes), and (2) that the number of times co-contraction and mixed m-modes were used were significantly higher for older adults, and the number of times reciprocal m-modes were used were significantly higher for young adults. These observations suggest that aging is associated with a reduced ability to unite dorsal and ventral muscles of the body, which may be reflective of the CNS developing a useful strategy when faced with self-triggered perturbations. © 2014 © 2014 Taylor & Francis.


Liu S.-S.,CAS Institute of Zoology | Liu S.-S.,Tianjin University of Sport
Annals of the New York Academy of Sciences | Year: 2010

We examined the intrinsic relation between two interdependent and interacted processes, namely, chemiosmotic energy coupling partition and redox signaling involved in mitochondrial respiration. The following aspects of research were conducted and discussed: generation sites and release sidedness of superoxide from the Q cycle of complex III of the mitochondrial respiratory chain; the different physiological roles of PMF components, ΔΨ and ΔpH (ΔpHS), of the Q cycle in mitochondrial superoxide generating and partitioning; and direct feedback effects of Q cycle-derived O2 •- on PMF energy partition through its interaction with protons in ΔpHS to form HO2 •, leading to decreasing ΔpHS and ATP synthesis due to its increasing effects of basic proton leak of mitochondria. The present experimental data give new evidence for our hypothesis of reactive oxygen species cycle cooperation with Q cycle and H+ cycle in respiratory chain in keeping PMF energy partition and its equilibrium with redox signaling regulation of mitochondrial respiration. © 2010 New York Academy of Sciences.


Liu W.,Tianjin University of Sport | Zhou C.,Shanghai University of Sport
Psychoneuroendocrinology | Year: 2012

Both chronic mild stress and an injection of corticosterone induce depression-like states in rodents. To further link mitochondrial dysfunction to the pathophysiology of major depression, here we describe two rat models of a depressive-like state induced by chronic unpredictable mild stress (CUMS) or corticosterone treatment (CORT). It is also a model that allows the simultaneous study of effects of exercise preconditioning on behavioral, electrophysiological, biochemical and molecular markers in the same animal. Exercise preconditioning ahead of CUMS and CORT treatment prevents many behavioral abnormalities resulted from CUMS. The changes in mitochondrial activity in brain and reduced expressions of superoxide dismutase (SOD1, SOD2), mitofusin (Mfn1, Mfn2) as well as brain-derived neurotrophic factor (BDNF) suggest that both CORT and CUMS may impair mitochondrial function and/or expressions of mitofusion and antioxidant enzymes that, in turn, may increase oxidative stress and reduce energy production in brain with depression-like behaviors. These findings suggest an underlying mechanism by which CORT, as well as CUMS, induces brain mitochondrial dysfunction that is associated with depressive-like states. Remarkably, physical exercise is identified as a helpful and preventive measure to promote mitochondrial function and expressions of mitofusin, BDNF and antioxidant enzymes in brain, so as to protect brain energy metabolism against CUMS, rather than the compound of corticosterone. © 2011 Elsevier Ltd.


Liao P.,Tianjin University of Sport | Zhou J.,Tianjin University of Sport | Ji L.L.,University of Wisconsin - Madison | Zhang Y.,Tianjin University of Sport
American Journal of Physiology - Regulatory Integrative and Comparative Physiology | Year: 2010

Eccentric contraction (EC) is known to elicit inflammation and damage in skeletal muscle. Proinflammatory cytokine TNF-α plays an important role in this pathogenesis, but the time course of its response to EC and the regulatory mechanisms involved are not clear. The purpose of the study is twofold: 1) to investigate the gene expression of TNF-α in rat muscle during and after an acute bout of downhill running and the associated oxidoreductive (redox) changes; and 2) to examine whether EC activates muscle ubiquitin-proteolytic pathway resulting in necrosis and oxidative damage. Female Sprague-Dawley rats (age 3 mo) were randomly divided into five groups (n = 6) that ran on treadmill at 25 m/min at - 10% grade for 1 h (group 1) or 2 h (group 2) and were killed immediately; ran for 2 h and killed at 6 h after exercise (group 3), ran for 2 h and killed at 24 h after exercise (group 4); and killed at rest as controls (group 5). TNF-α mRNA and protein content showed progressive increases in the deep portion of vastus lateralis (DVL) and gastrocnemius muscles during and after EC. These changes were accompanied by a progressive decrease of mitochondrial aconitase activity and NF-κB activation. After 2 h of exercise, elevated levels of serum TNF-α, endotoxin, creatine kinase, and lipid peroxidation marker were evident and persisted through 24 h postexercise. At 24 h, there were marked increases in H2O2 concentration, myleoperoxidase activity, and endotoxin level, along with nuclear accumulation of p65, in both muscles. mRNA level of ubiquitin-conjugating enzymes (E2)-14k was progressively upregulated during exercise and recovery, whereas the expression of the Toll-like receptor 4 (TLR4) in DVL was downregulated in both muscles. We conclude that prolonged EC induces TNF-α expression possibly due to NF-κB activation stimulated by increased reactive oxygen species generation and endotoxin release. These inflammatory and prooxidative responses may underlie the processes of muscle proteolysis and oxidative damage. Copyright © 2010 the American Physiological Society.


Sijie T.,Tianjin University of Sport | Hainai Y.,Tianjin University of Sport | Fengying Y.,Tianjin Medical University | Jianxiong W.,University of Southern Queensland
Journal of Sports Medicine and Physical Fitness | Year: 2012

Aim. The purpose of this study was intended to evaluate the effects of a high intensity interval training (HIIT) program on the body composition, cardiac function and aerobic capacity in overweight young women. Methods. Sixty female university students (aged 19-20, BMI≥ 25kg/m 2 and percentage body fat 2 30%) were chosen and then randomly assigned to each of the HIIT group, the moderate intensity continuous training (MICT) group and the non-training control group. The subjects in both the HIIT and MICT groups underwent exercise training five times per week for 12 weeks. In each of the training sessions, the HIIT group performed interval exercises at the individualized heart rate (HR) of 85% of VO 2max and separated by brief periods of low intensity activity (HR at 50% of VO 2max), while the MICT group did continuous walking and/or jogging at the individualized HR of 50% of VO 2max. Results. Both of these exercise training programs produced significant improvements in the subjects' body composition, left ventricular ejection fraction, heart rate at rest, maximal oxygen uptake and ventilatory threshold. However, the HIIT group achieved better results than those in the MICT group, as it was evaluated by the amount of the effect size. The control group did not achieve any change in all of the measured variables. Conclusion. The tangible results achieved by our relatively large groups of homogeneous subjects have demonstrated that the HIIT program is an effective measure for the treatment of young women who are overweight.


Qi F.,Tianjin University of Sport
International Journal of Advancements in Computing Technology | Year: 2012

The problem of evaluating the sports management system with interval-valued intuitionistic fuzzy information is the multiple attribute decision making (MADM) problems. In this paper, we investigate the multiple attribute decision making (MADM) problems for evaluating the sports management system with interval-valued intuitionistic fuzzy information. We utilize the interval-valued intuitionistic fuzzy weighted averaging (IVIFWA) operator to aggregate the interval-valued intuitionistic fuzzy information corresponding to each alternative, and then rank the alternatives and select the most desirable one(s) according to the score function and accuracy function. Finally, an illustrative example for sports management system with interval-valued intuitionistic fuzzy information is given.

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