Tianjin Third Central Hospital Tianjin

Tianjin, China

Tianjin Third Central Hospital Tianjin

Tianjin, China

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PubMed | Tianjin University, Tianjin Medical University and Tianjin Third Central Hospital Tianjin
Type: Journal Article | Journal: International journal of clinical and experimental pathology | Year: 2015

Interferon Gamma gamma (IFN-) 13-CA-repeats polymorphism is associated with a variety of diseases; here we report its association with nasopharyngeal carcinoma (NPC) metastasis in a retrospective analysis of a cohort of 220 NPC patients in the northern China. The results showed that the distributions of CA13-/CA13-genotypes were significantly higher in the patients with lymph node metastasis (P<0.05) and distant metastasis (P<0.001); there was a significant difference between NPC patients with stage I+II and those with stage III+IV regarding CA13+/CA13-(P<0.001) and CA13-/CA13- genotypes (P<0.001); further analysis showed a more pronounced difference between NPC patients with stage I+II+III and those with stage IV for CA13-/CA13-genotype (P<0.001), whereas no difference was found for CA13+/CA13- genotype (P=0.790). Thus, we identify that IFN- 13-CA-repeat polymorphism is significantly associated with the metastasis of NPC, which may provide insights into its prognosis and individualized treatment.


PubMed | Tianjin Medical University and Tianjin Third Central Hospital Tianjin
Type: Journal Article | Journal: International journal of clinical and experimental pathology | Year: 2015

Insular thyroid carcinoma (ITC) is a rare type of thyroid malignancy whose aggressiveness and propensity to local recurrence differentiate it from other thyroid malignancies. However, data pertaining to its clinical characteristics is still lacking. In this study, we retrospectively analyzed 10 ITC patients treated and followed in Tianjin Medical University Cancer Institute and Hospital during Apr 2007 to Aug 2010, and compared the clinical and pathological characteristics and long-term follow-up with 2220 patients with papillary thyroid carcinoma (PTC). These ten ITC cases comprised 7 women and 3 men, of whom 6 patients are multifocal ITC (mITC) and showed cervical lymph node metastasis to the lateral compartment, while the other 4 solitary ITC (sITC) had regional metastasis confined to level VI or even no cervical metastasis. The ITC group had more frequent retrosternal metastasis (40% vs. 7.5%), recurrent laryngeal nerve invasion (40% vs. 4.4%), esophageal invasion (50% vs. 1.9%), a higher proportion of distant metastasis (50% vs. 3.2%), and vascular invasion (50% vs. 1.0%). While the presence of lymph node metastasis showed no significant difference. Interestingly, although patients with ITC are lacking in number to perform survival analysis, we still noticed that all the four sITC patients (4/4, 100%) have survived much longer (at least 45 months) than those who have multinodularity (mITC, 5/6, 83.3%). Our results indicated that ITC is an aggressive disease and the presence of multifocality might be a risk factor for long time survival of ITC patients.

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