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Tianjin, China

Chen X.,Minzu University of China | Zhuang S.,Minzu University of China | Hou X.,Tianjin Port Hospital | Liu Q.,Minzu University of China
Advanced Materials Research

Neural stem cells (NSCs), as therapeutic agents, play the key role in the treatment of central nervous system (CNS) disorders. It is a researching tendency for promote proliferation and differentiation of neural stem cells by using tissue engineering. It is discovered that joint use neural stem cells and NSCs-seeded scaffold may increase the cell survival state and better control cellular microenvironment. We find suitable material include natural biological materials, synthetic materials, compound materials, bio-derived materials and 3D-materials of neural stem cells tissue engineering by analyzing and summing up of the research which combine tissue engineering with NSCs transplant in past several years. It hold out a hope of the possibility of utilizing the treatment of neural stem cells transplantation with tissue engineering, and there has been a great quantity of achievements on the research of it to treat CNS disorders by promote proliferation and differentiate. © (2012) Trans Tech Publications, Switzerland. Source

Li W.-C.,Tianjin Port Hospital
Chinese Journal of Tissue Engineering Research

Background: Antibiotic bone cement is the important method for the prevention and treatment of infection after artificial hip replacement and renovation. Objective: To review the research progress of antibiotic bone cement. Methods: A computer-based online search was performed in PubMed database, CNKI database, Chinese Biomedical Literature database, VIP database and Wanfang database for the literatures from 1978 to 2012. The key words were "bone cement, antibiotic bone cement, infection, joint replacement" in English and Chinese. Resutls and conclusion: A total of 335 literatures were screened out. Finally, 29 literatures were included for in-depth analysis after the primary screen through reading the title, abstract and full-text. Antibiotic bone cement has been widely used in the treatment of infection after artificial joint replacement and renovation as it can reduce the risk of infection after initial joint replacement and renovation. The material properties and mechanical properties will not change after bone cement mixed with appropriate amount of antibiotic. Different antibiotics in the bone cement have different release rates, which were closely related with the porosity of bone cement. Adding the additive that used for increasing the porosity of bone cement can increase the antibiotic release. Source

Liu G.,Shanxi Medical University | Liang B.,Shanxi Medical University | Song X.,Shanxi Medical University | Bai R.,Shanxi Medical University | And 5 more authors.
Molecular Medicine Reports

Platelet activation is important in hypertension-induced cardiac inflammation and fibrosis. P-selectin expression significantly (P<0.05) increases when platelets are activated during hypertension. Although P-selectin recruits leukocytes to sites of inflammation, the role of P-selectin in cardiac inflammation and fibrosis remains to be elucidated. The present study aimed to investigate whether platelet-derived P-selectin promotes hypertensive cardiac inflammation and fibrosis. P-selectin knockout (P-sel KO) mice and wild-type (WT) C57BL/6 littermates were infused with angiotensin II (Ang II) at 1,500 ng/kg/min for 7 days and then cross-transplanted with platelets originating from either WT or P-sel KO mice. P-selectin expression was increased in the myocardium and plasma of hypertensive mice, and the P-sel KO mice exhibited significantly (P<0.05) reduced cardiac fibrosis. The fibrotic areas were markedly smaller in the hearts of P-sel KO mice compared with WT mice, as assessed by Masson's trichrome staining. In addition, α-smooth muscle actin and transforming growth factor β1 (TGF-β1) expression levels were decreased in the P-sel KO mice, as assessed by immunohistochemistry. Following platelet transplantation into P-sel KO mice, the number of Mac-2 (galectin-3)-and TGF-β1-positive cells was increased in mice that received WT platelets compared with those that received P-sel KO platelets, and the mRNA expression levels of collagen I and TGF-β1 were also increased. The results from the present study suggest that activated platelets secrete P-selectin to promote cardiac inflammation and fibrosis in Ang II-induced hypertension. Source

Gao C.,Tianjin Medical University | Fu X.,Tianjin Port Hospital | Pan Y.,Tianjin Medical University | Li Q.,Tianjin Medical University
Digestive Surgery

Objectives: To review the clinical data of a group of patients with pancreatic neuroendocrine tumors (pNETs) and to investigate the role of surgery in the treatment for pNETs by analyzing clinical manifestations and postoperative course of this rare disease. Methods: A total of 112 patients (aged 21-76 years; 45 males) who underwent treatment between 1980 and 2003 were recruited in this study. Patients' data related to demographics and characteristics, diagnostic studies, surgical and tumor characteristics and survival were retrospectively reviewed. Results: Forty-six patients (41.1%) had a well-differentiated neuroendocrine tumor (WDT), 44 (48.2%) a well-differentiated neuroendocrine carcinoma (WD-Ca) and 12 (10.7%) a poorly differentiated neuroendocrine carcinoma (PD-Ca). Nonfunctional tumors were seen in 65 (58.0%) patients, whereas functional tumors were found in 47 (42.0%) patients, including 26 insulinomas, 17 gastrinomas, 2 VIPomas, 1 glucagonoma, and 1 ACTHoma. The sensitivity of computed tomography was 87.1%. Surgical resection was performed in 99 (88.4%) patients. Thirty-eight (33.9%) patients underwent partial pancreaticoduodenectomy, 32 (28.6%) had distal pancreatectomy and 29 (25.9%) underwent enucleation. No surgery-related death occurred. The common postoperative complications were pancreatic fistula (15.2%), wound infection (13.4%) and delayed gastric emptying (6.3%). Three (5%) patients had reoperation due to intra-abdominal abscess and postoperative hemorrhage. Twenty-six (55.3%) of the 47 functional tumors were malignant, whereas 40 (61.5%) of the 65 nonfunctional tumors were malignant. Survival was significantly related to the type of neuroendocrine tumor (p = 0.001). The overall 5-year actual survival rate of patients with WD-Ca (n = 54) was 56%, significantly less than that of patients with WDT (n = 46, 91%, p = 0.001). All the patients of PD-Ca (n = 12) group died in 5 years. The 5-year survival rate differed significantly between patients with tumor node metastasis (TNM) stage I and II disease and those with stage III and IV tumors (p = 0.011). Patients with stage III had better prognosis than those with stage IV tumors (p = 0.007). Patients' long-term survival was closely correlated with vascular invasion (p = 0.008) and resection margin (p = 0.004). Conclusions: PNETs can be safely resected. Microscopic vascular invasion and positive resection margin are helpful for predicting patient survival. Malignant cases should be treated with aggressive radical surgery to achieve complete tumor resection and potential for long-term survival. Copyright © 2010 S. Karger AG, Basel. Source

Xiuju C.,Tianjin Nankai Hospital | Zhen W.,Tianjin Nankai Hospital | Yanchao S.,Tianjin Port Hospital
Open Medicine (Poland)

Several studies have investigated the correla- tion between adiponectin gene rs22411766 T>G polymor- phism and ischemic stroke risk. However, the results were not conclusive with each other. Therefore, to overcome this obstacle, we performed this meta-analysis to further explicate the adiponectin gene rs22411766 T>G polymor- phism and ischemic stroke susceptibility. Case-control or cohort studies focused on adiponectin gene rs22411766 T>G polymorphism and ischemic stroke risk were elec- tronic searched in the databases of Medline, Pubmed, Cochrane library, Excerpta Medica database(EMBASE) and China National Knowledge Infrastructure (CNKI). All the potentially relevant studies were included in this meta-analysis. The association between adiponectin gene rs22411766 T>G polymorphism and ischemic stroke was expressed by odds ratio with its confidence interval. Publication bias has been assessed by begg's funnel plot. All the analyses have been performed by Revman 5.1 sta- tistical software. Finally, a total of six studies with 1,345 cases and 1,421 controls were included in this meta-analy- sis. Our results demonstrated that there was a significant association between adiponectin gene rs22411766 T>G polymorphism and ischemic stroke risk (p<0.05). People with G single nucleotide of adiponectin gene have the increased risk of developing ischemic stroke compared to T single nucleotide. © 2016 Chen Xiuju. Source

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