Tianjin Orthopedic Hospital

Tianjin, China

Tianjin Orthopedic Hospital

Tianjin, China
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Li Z.,Tianjin University | Kong W.,Tianjin University | Li X.,Tianjin Orthopedic Hospital | Xu C.,Beijing 302 Hospital | And 8 more authors.
Journal of Biomaterials Science, Polymer Edition | Year: 2011

The construction of inorganic bone fillers with a suitable degradation period to match the new bone growth is an urgent task since most bone fillers have an either too fast or slow degradation rate. Calcium sulfate, as a commonly used implanting material, shows good biocompatibility, biodegradability, osteoconductivity and mechanical properties. However, its degradation rate and the drug-release rate are too rapid to meet the requirements for clinical application. In this paper, calcium sulfate bead clusters (CSBC), with or without loaded drug, were prepared; and two kinds of coatings, porous or nonporous, were deposited on the surface of the beads to extend the degradation and the drug release period. The results show that poly(lactic acid-glycolic acid) (PLGA) coatings, incorporated with different porogens can form in situ porous coatings that obviously lengthen the degradation period of the beads from 30 days to around 60-90 days. Consequently, the drug-release rate was significantly reduced, and the release period increased from about 10 days to over 50 days. © 2011 Koninklijke Brill NV, Leiden.


Zhang Y.,Huanhu Hospital | Gao C.,Tianjin University | Li X.,Tianjin Orthopedic Hospital | Xu C.,Beijing 302 Hospital | And 4 more authors.
Carbohydrate Polymers | Year: 2014

Thermosensitive methyl cellulose (MC)-based injectable hydrogels for post-operation anti-adhesion were prepared by integrating polyethylene glycol (PEG), carboxymethyl cellulose (CMC) and chitosan sulfate (CS-SO3) with MC sols. The viscosity of the MC-based sols depended on the sol composition, especially the amount of CMC. The gelation temperature of the sols was tuned by adjusting the concentrations of K+ and other components to obtain an MC-based sol that transformed to a gel at body temperature. The composition of the sol also affected the gel strength. Adding PEG decreased the repulsions between the CMC and CS-SO3 macromolecules and thus increased the gel strength. The efficacy of the MC-based injectable hydrogels as barriers for reducing postsurgical adhesions was evaluated using a rat cecal abrasion model. The PEG and CS-SO3 loaded MC-based injectable hydrogels were effective in reducing adhesion formation and reduced adhesiolysis difficulties. © 2013 Published by Elsevier Ltd.


Wen P.,Tianjin University | Gao J.,Tianjin University | Zhang Y.,Tianjin Huanhu Hospital | Li X.,Tianjin Orthopedic Hospital | And 8 more authors.
Journal of Biomaterials Science, Polymer Edition | Year: 2011

Chitosan, as an example of natural macromolecular biomaterials, was used to fabricate highly porous chitosan scaffolds with microtubules having a tubular orientation structure using the unidirectional freeze-drying method. The porous structure of the scaffolds was characterized via scanning electron microscopy. The factors that affect the porous structure of the scaffolds, such as the concentration of chitosan solution and addition of glutaraldehyde as cross-linking agent, have been extensively studied in order to find a facile and efficient way to control the porosity, tubular morphology and orientation of the microtubules. The properties of the chitosan scaffolds, including water absorption ability, compressive strength, protein adsorption and in vitro enzymatic biodegradation in the presence of lysozyme, were also investigated. In vitro cell-culture results showed that the chitosan scaffold was non-toxic to cartilage cells and the cells could spread and grow well on the scaffolds. © 2011 VSP.


Zhang Y.,Huanhu Hospital | Zhang Y.,Tianjin Cerebral Vascular and Neural Degenerative Disease Key Laboratory | Gao C.,State Oceanic Administration | Zhao W.,Huanhu Hospital | And 11 more authors.
RSC Advances | Year: 2014

Porous chitosan/gelatin (CS/Gel) foams with ordered porous structures were prepared by a unidirectional freeze-drying method. The CS/Gel foams had ordered porous structures with high porosities. The porosity of the foam depended on the concentration of the CS/Gel preparation solution and the CS/Gel ratio. The CS/Gel concentration affected the compressive strength of the porous CS/Gel foams and higher concentrations resulted in better strength. The CS/Gel ratio affected both the compressive strength and the degradation rate of the CS/Gel foam. Low CS/Gel ratios resulted in foams with higher compressive strength and higher degradation rates. The CS/Gel foams had a high adsorption capacity for aqueous Pb2+ and Co2+ ions and fetal bovine serum. In addition, gentamicin loaded CS/Gel foams had different release rates which depended on the composition and porous structure of the foams. The CS/Gel foams should be useful as scaffolds for cell cultures or drug releasing implants. This journal is © the Partner Organisations 2014.


Wu X.,Tianjin University | Liu Y.,Tianjin University | Li X.,Tianjin Orthopedic Hospital | Wen P.,Tianjin University | And 6 more authors.
Acta Biomaterialia | Year: 2010

Porous gelatin scaffolds with microtubule orientation structure were manufactured by unidirectional freeze-drying technology, and their porous structure was characterized by scanning electron microscopy. Scaffolds with tunable pore size and high porosity up to 98% were obtained by adjusting the concentration of the gelatin solution and crosslinking agent during the preparation process. All the porous gelatin scaffolds exhibited oriented microtubule pores, with width and length from 50 to 100 μm and 100 to 500 μm, respectively. Meanwhile, the properties of the scaffolds, such as porosity, water adsorption ability and compressive strength, were studied. In vitro enzymatic degradation results showed that the absolute weight loss of the gelatin scaffolds exhibited an increasing trend from low to high gelatin concentration used to prepare gelatin scaffolds; in vitro cell culture results indicated that the porous gelatin scaffolds were non-toxic to cartilage cells, since the cells spread and grew well. © 2009 Acta Materialia Inc.


Han Y.,Tianjin Orthopedic Hospital
Zhonghua yi xue za zhi | Year: 2011

To analyze the functional efficacies and complications for the reconstruction of defects in proximal humerus tumors with massive osteoarticular allograft transplantation and evaluate the feasibility of this method. A retrospective review was performed for proximal humerus tumors surgically treated and followed up from November 2001 to November 2008. There were 6 males and 1 female with an average age of 38.4 years old (range: 21 - 65). The tumor characteristics were as follows: giant cell tumor (n = 5), osteosarcoma (n = 1) and malignant fibrous tissue tumor (n = 1). According to the Enneking classification system, there were IA (n = 5), IIA (n = 1) and IIB (n = 1). All patients were reconstructed with massive osteoarticular allograft transplantation and immobilized with interlocking nail. The average length of massive allograft was 15.2 cm (range: 11 - 19). All patients were followed up for an average of 5.5 years (range: 2 - 8). In a long-term follow-up, atrophy and adsorption of allograft were found in all cases without clinical symptoms. This phenomenon started to appear after 1.5 years. And bone graft disappeared completely in around 6 years postoperatively. The atrophy of bone graft usually originated from greater tubercles and extended gradually to metaphysic. According to the Musculoskeletal Tumor Society (MSTS) functional classification system, the average score of osteoarticular allografts was 17.6 (range: 15 - 19). According to the MSTS radiological evaluation system, the long-term perfect/fair rate was 0. Massive osteoarticular allograft transplantation is one of feasible options for the reconstruction of structural bone defects due to bone tumor resection.


Han Y.,Tianjin Orthopedic Hospital | Hu Y.-C.,Tianjin Orthopedic Hospital
National Medical Journal of China | Year: 2011

Objective: To analyze the functional efficacies and complications for the reconstruction of defects in proximal humerus tumors with massive osteoarticular allograft transplantation and evaluate the feasibility of this method. Methods: A retrospective review was performed for proximal humerus tumors surgically treated and followed up from November 2001 to November 2008. There were 6 males and 1 female with an average age of 38.4 years old (range: 21-65). The tumor characteristics were as follows; giant cell tumor (n=5), osteosarcoma (n=1) and malignant fibrous tissue tumor (n=1). According to the Enneking classification system, there were I A (n=5), II A (n=1) and II B (n=1). All patients were reconstructed with massive osteoarticular allograft transplantation and immobilized with interlocking nail. The average length of massive allograft was 15.2 cm (range: 11-19). Results: All patients were followed up for an average of 5.5 years (range: 2-8). In a long-term follow-up, atrophy and adsorption of allograft were found in all cases without clinical symptoms. This phenomenon started to appear after 1.5 years. And bone graft disappeared completely in around 6 years postoperatively. The atrophy of bone graft usually originated from greater tubercles and extended gradually to metaphysic. According to the Musculoskeletal Tumor Society (MSTS) functional classification system, the average score of osteoarticular allografts was 17.6 (range: 15-19). According to the MSTS radiological evaluation system, the long-term perfect/fair rate was 0. Conclusion: Massive osteoarticular allograft transplantation is one of feasible options for the reconstruction of structural bone defects due to bone tumor resection. Copyright © 2011 by the Chinese Medical Association.

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