Tianjin Neurosurgery Institute

Tianjin, China

Tianjin Neurosurgery Institute

Tianjin, China
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Li X.,Tianjin University of Traditional Chinese Medicine | Jia Y.,Tianjin University of Traditional Chinese Medicine | Zhang A.,Tianjin Neurosurgery Institute | Zhang Y.,Tianjin University of Traditional Chinese Medicine | And 5 more authors.
Chinese Journal of Lung Cancer | Year: 2011

Being the most critical signaling molecule in the Wnt pathway, the Wnt/β-catenin signaling pathway plays an important role in the maintenance of the cell proliferation and clone formation of lung cancer stem cells. Since it is closely related to the WNT pathway, the proliferation of lung cancer stem cells can be restrained by blocking the WNT pathway or influencing its key protein. Such method provides a new method for the treatment of lung cancer. By summarizing the state ofthe- art research of lung cancer stem cells and the Wnt pathway from 2005 to 2010, their relationship is investigated.


Li X.-J.,Tianjin University of Traditional Chinese Medicine | Jia Y.-J.,Tianjin University of Traditional Chinese Medicine | Zhang W.-Z.,Tianjin Neurosurgery Institute | Zhang Y.,Tianjin University of Traditional Chinese Medicine | And 2 more authors.
Chinese Traditional and Herbal Drugs | Year: 2013

Objective: To evaluate the effect of curcumin on A549 tumor cell growth of subsets SP and NON-SP cells and the specific targets. Methods: The subsets SP and NON-SP cells were separated from A549 tumor strain of the human lung adenocarcinoma, and these cells were identified with soft agar clone formation test and tumorigenicity in vitro. Curcumin with different concentration (10, 20, 30, and 40 μmol/L) was used to deal with these cells. Using MTT method to make sure the inhibition of curcumin on the growth of SP and NON-SP cells. PCR was used to measure the expression of survivin and caspase-3. Results: Curcumin at different concentration showed the different inhibition on SP and NON-SP cells. Curcumin (30 μmol/L) showed more inhibition on SP cells than NON-SP cells with the lowest cell viability and was time-dependent. Curcumin could suppress the expression of survivin and promote the expression of caspase-3. The apoptosis degree of SP cell was clearly higher than that of NON-SP cell. Conclusion: Tumorigenicity of SP cell is higher than that of NON-SP cell. Curcumin induces the apoptosis of tumor cells through inhibiting the growth of SP cell, down-regulating the expression of survivin, and promoting the expression of caspase-3 gene.

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