Tianjin Key Laboratory of Ophthalmology and Visual Science

Heping, China

Tianjin Key Laboratory of Ophthalmology and Visual Science

Heping, China
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Liu Y.,Tianjin Medical University | Dong Y.,Tianjin Eye Hospital | Zhao K.,Tianjin Medical University | Zhao K.,Tianjin Eye Hospital | And 2 more authors.
Journal of Ophthalmology | Year: 2017

Purpose. To date, the topic of amblyopic changes remains controversial. Therefore, a systematic review and meta-analysis were carried out to evaluate choroidal changes in unilateral amblyopia. Methods. Major literature databases were searched for amblyopia-relevant studies. Using enhanced depth imaging optical coherence tomography (EDI-OCT), the primary outcome parameters examined were subfoveal choroidal thickness (SFCT) and different choroidal thickness (CT) positions. Efficacy estimates were evaluated by weighted mean difference (WMD) and 95% confidence interval (CI) for choroidal-associated changes. We performed subgroup analysis and metaregression analysis to examine potential sources of heterogeneity. Results. Eleven cross-sectional studies that included a total of 768 participants were identified. The amblyopic eye SFCT was thicker than that of the fellow and control (normal) eyes (WMDamblyopia versus fellow=49.24, 95% CI of 30.22 to 68.27, p<0.001; WMDamblyopia versus control=54.51, 95% CI of 32.17 to 76.85, p<0.001). There were no differences between the fellow and control eyes (WMD=13.81, 95% CI of 1.16 to 28.77, p=0.071). Subgroup and metaregression analyses indicated that the OCT type was the main source of heterogeneity. Conclusions. The CT in the amblyopic eyes was thicker than that in the fellow and control eyes. © 2017 Yanli Liu et al.


Wei S.,Tianjin Medical University | Wei S.,Tianjin Key Laboratory of Ophthalmology and Visual Science | Song H.,Tianjin Medical University | Song H.,Tianjin Key Laboratory of Ophthalmology and Visual Science | And 3 more authors.
Cornea | Year: 2014

PURPOSE: The aim of this study was to investigate the distribution of higher-order aberrations (HOAs) of the anterior cornea of eyes with cataract in a senior Chinese population and their correlations with age. METHODS: Four hundred ten Chinese patients (male/female: 196/214; age: 67.9 ± 10.0 years) with cataract were categorized into 5 groups according to their age. The HOAs in the central 6-mm zone of the cornea were measured with an iTrace wavefront analyzer. The correlations between age and total HOA, coma aberration, trefoil aberration, and spherical aberration were assessed using Spearman analysis. The differences in total HOA, coma aberration, trefoil aberration, spherical aberration among various age groups were analyzed using the Kruskal-Wallis H test. RESULTS: The corneal HOA exhibited a nonnormal distribution. A weak correlation was found between age and total HOA, coma aberration (Z3±3), trefoil aberration (Z 3±1) (P < 0.001 for all). No correlation was found between age and spherical aberration (Z40). Differences in the root mean square of the total HOA, Z3 ±1, and Z3±3 were found among various age groups (P < 0.05). No difference was found in the root mean square of Z40, spherical diopter, corneal curvature, corneal astigmatism, corneal effective refractive power, corneal asphericity Q value and corneal central power across the groups. CONCLUSIONS: The distribution of anterior corneal HOAs of eyes with cataract in a senior Chinese population is of the nonnormal type. The total HOA, Z3±1, and Z3±3 are correlated to age, unlike Z4 of the anterior cornea. Copyright © 2014 by Lippincott Williams & Wilkins.


Xiang Y.,Tianjin Medical University | Dong Y.,Tianjin Medical University | Dong Y.,Tianjin Eye Hospital | Li X.,Tianjin Medical University | And 7 more authors.
Journal of Ophthalmology | Year: 2016

Purpose. To clarify the association of endothelial nitric oxide synthase (eNOS) polymorphisms and primary open angle glaucoma (POAG). Methods. After a systematic literature search in the MEDLINE, EMBASE, and ISI Web of Science databases, all relevant studies evaluating the association between the polymorphisms (rs2070744 and rs1799983) of eNOS gene and POAG were screened and included. The pooled odds ratios (ORs) and the 95% confidence interval (CI) of each single-nucleotide polymorphism (SNP) in five genetic models were estimated using fixed-effect model if I 2 < 50 % in the test for heterogeneity; otherwise the random-effects model was used. Results. Thirty-one records were obtained, with five being suitable for meta-analysis. The overall results showed that both TT genotype in rs2070744 and GG genotype in rs1799983 are associated with decreased risk of POAG susceptibility. Stratified analysis based on ethnicity showed that the association of rs2070744 with POAG remained only in Caucasians. Results of subgroup analysis by sex indicated association between both polymorphisms and POAG in female group, but not in male group. Conclusions. TT genotype and/or T-allele in rs2070744, as well as GG genotype and/or G-allele in rs1799983, was associated with decreased risk for POAG overall and in female group. © 2016 Yang Xiang et al.


Song J.,Tianjin Medical University | Chen S.,Tianjin Medical University | Chen S.,Tianjin Eye Hospital | Chen S.,Tianjin Key Laboratory of Ophthalmology and Visual Science | And 5 more authors.
PLoS ONE | Year: 2015

Objectives: To date, the relationship between C-reactive protein (CRP) level and diabetic retinopathy (DR) remains controversial. Therefore, a systematic review and meta-analysis was used to reveal the potential relationship between CRP level and DR. Methods: A systematic search of PubMed, Embase.com, and Web of Science was performed to identify all comparative studies that compared the CRP level of two groups (case group and control group). We defined that diabetic patients without retinopathy and /or matched healthy persons constituted the control group, and patients with DR were the case group. Results: Two cross sectional studies and twenty case control studies including a total of 3679 participants were identified. After pooling the data from all 22 studies, obvious heterogeneity existed between the studies, so a subgroup analysis and sensitivity analysis were performed. Removing the sensitivity studies, the blood CRP levels in the case group were observed to be higher than those in the control group [SMD = 0.22, 95% confidence interval (CI), 0.11-0.34], and the blood CRP levels in the proliferative diabetic retinopathy (PDR) group were also higher than those in the non-proliferative diabetic retinopathy (NPDR) group [SMD = 0.50, 95% CI, 0.30-0.70]. Conclusions: The results from this current meta-analysis indicate that the CRP level might be used as a biomarker to determine the severity of DR. © 2015 Song et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Wei S.,Tianjin Eye Hospital | Wei S.,Tianjin Key Laboratory of Ophthalmology and Visual Science | Wei S.,Tianjin Eye Institute | Wei S.,Tianjin Medical University | And 8 more authors.
Optik | Year: 2016

This study aimed to investigate the distribution of total high-order aberrations (HOAs) Z3 ±1, Z4 0, and Z3 ±3 of anterior cornea and their correlations to astigmatism. In addition, the relationship between different axes of astigmatism and Z3 -1 or Z3 1 was analyzed. The HOAs in the central 6-mm zone of the cornea were measured with an iTrace wavefront analyzer in 556 cataractous eyes at the Tianjin Eye Hospital in China. Simulated keratoscope readings (Sim k) were also measured with the analyzer. The corneal total HOAs Z3 ±1, Z4 0 and Z3 ±3 exhibited a non-normal distribution. Significant correlations were found between the topographic-simulated keratometric power (ΔSim k) with the axis at 180° ± 5° and absolute value of Z3 -1 (P = 0.008), the ΔSim k with the axis at 90° ± 5° and absolute value of Z3 1 (P < 0.001), and the ΔSim k and total HOAs (P < 0.001), Z3 ±1 (P < 0.001), and Z3 ±3 (P < 0.001). No significant correlation was found between ΔSim k and Z4 0 (P = 0.404). In conclusion, corneal astigmatism with the axis near the horizontal position was mainly associated with the value of Z3 -1. Corneal astigmatism with the axis near the vertical position was mainly related to the value of Z3 1. HOAs except Z4 0 are correlated with astigmatism. © 2016 Elsevier GmbH.


Hou J.,Tianjin Medical University | Hou J.,Tianjin Eye Hospital | Hou J.,Tianjin Key Laboratory of Ophthalmology and Visual Science | Hou J.,Tianjin Eye Institute | And 8 more authors.
Journal of Ophthalmology | Year: 2016

Purpose. To evaluate the changes in epithelial thickness profile following transepithelial photorefractive keratectomy (T-PRK) for myopia and to investigate the effect of epithelial remodeling on corneal asphericity. Methods. Forty-four patients (44 right eyes) who underwent T-PRK were retrospectively evaluated. Epithelial thickness was measured using spectral-domain optical coherence tomography at different corneal zones (central, 2 mm; paracentral, 2-5 mm; and mid-peripheral, 5-6 mm) preoperatively and at 1 week and 1, 3, and 6 months postoperatively. The correlation between the changes in corneal epithelial thickness (ΔCET) and postoperative Q -value changes (ΔQ) was analyzed 6 months postoperatively. Results. Epithelial thickness at 6 months showed a negative meniscus-like lenticular pattern with less central thickening, which increased progressively toward the mid-periphery (3.69 ± 4.2, 5.19 ± 3.8, and 6.23 ± 3.9 μm at the center, paracenter, and mid-periphery, resp., P < 0.01). A significant positive relationship was observed between epithelial thickening and ΔQ 6 months postoperatively (r = 0.438, 0.580, and 0.504, resp., P < 0.01). Conclusions. Significant epithelial thickening was observed after T-PRK and showed a lenticular change with more thickening mid-peripherally, resulting in increased oblateness postoperatively. Epithelial remodeling may modify the epithelial thickness profile after surface ablation refractive surgery for myopia. © 2016 Jie Hou et al.


Ying M.,Tianjin Eye Hospital | Ying M.,Tianjin Key Laboratory of Ophthalmology and Visual Science | Han R.,Tianjin Eye Hospital | Han R.,Tianjin Eye Institute | And 8 more authors.
BMC Medical Genetics | Year: 2013

Background: Mutations in the KIF21A gene are detected in the patients with congenital fibrosis of the extraocular muscles. Mutations in the PAX6 gene are detected in the patients with congenital aniridia.Case presentation: Herein we report a boy with both congenital fibrosis of extraocular muscles and aniridia. Sequence analysis of his KIF21A and PAX6 genes reveals a 1-bp deletion (c.745delC) in the PAX6 gene and a missense mutation of c.2860C > T (p.Arg954Trp) in KIF21A.Conclusions: This study demonstrates that the occurrence of independent mutations in more than a single gene in a patient may lead to a complex phenotype. © 2013 Ying et al.; licensee BioMed Central Ltd.


Kong Y.,Tianjin Eye Hospital | Kong Y.,Tianjin Key Laboratory of Ophthalmology and Visual Science | Kong Y.,Tianjin Eye Institute | Kong Y.,Tianjin Medical University | And 17 more authors.
International Journal of Molecular Medicine | Year: 2016

miR-218 is an important intronic microRNA (miRNA or miR) which is known to regulate angiogenesis in tumors. The present study aimed to investigate the effects of miR-218, as well as its host genes, Slit2 and Slit3, on oxygen-induced retinal neovascularization (RNV) and to explore the associated mechanisms of action. For this purpose, a mouse model of oxygen-induced retinopathy (OIR) was established. The expression levels of miR-218-1 and miR-218-2, as well as those of their host genes, Slit2 and Slit3, were determined by RT-qPCR. Fluorescein angiography was performed on the retinas of the mice with OIR, and RNV was quantified by H&E staining in order to evaluate the effect of pCDH-CMV-miR-218 intravitreal injection on RNV in the mouse model of OIR. Roundabout, axon guidance receptor, homolog 1 (Robo1) expression was detected in mouse retinal vascular endothelial cells expressing high or low levels of miR-218 and in retinal tissues from mice with OIR by western blot analysis. Cell migration was evaluated by a scratch wound assay. We noted that in the mice with OIR, the expression level of miR-218 was significantly downregulated. We also noted that Robo1 expression was suppressed by miR-218. Furthermore, in the mice with OIR, the expression level of miR-218 was significantly downregulated, and that of miR-218-1 and its host gene, Slit2, was concomitantly downregulated as well. The restoration of miR-218 inhibited retinal angiogenesis by targeting Robo1. Taken together, our findings suggest that the Slit2-miR-218-Robo1 axis contributes to the inhibition of retinal angiogenesis and that miR-218 may be a new therapeutic target for preventing RNV.

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