Li Y.-P.,Tianjin University of Traditional Chinese Medicine |
Chen X.-Y.,Tianjin Key Laboratory of Neurological Trauma Repair |
Chen X.-Y.,Tianjin University |
Chen X.-Y.,College of Logistics |
And 7 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2015
BACKGROUND: Acellular spinal cord matrix material for framework of spinal cord scaffold has been shown to restore the neurologic function of the damaged spinal cord completely or partially. OBJECTIVE: To introduce the preparation and biological characteristics of acellular matrix scaffold for the spinal cord and to do an overview of its application and progress in spinal cord tissue engineering. METHODS: A computer-based search of CNKI and PubMed was performed for articles related to acellular spinal cord scaffolds published from January 2005 to October 2014. The keywords were “acellular spinal cord; scaffold; spinal cord injury; tissue engineering” in Chinese and English, appearing in the title and abstract. RESULTS AND CONCLUSION: The acellular spinal cord scaffold has low antigenicity, excellent biocompatibility and three-dimensional scaffold structure similar to the spinal cord, but it also possesses poor mechanical properties and structural instability. The scaffold modified by genipin and glutaraldehyde as cross-linking agents can be significantly improved in the biological performance. Currently, there are some explorations on the application of acellular spinal cord scaffold in nerve repair and regeneration, which lays a foundation for spinal cord tissue engineering. As its lots of advantages, the acellular spinal cord matrix material is expected to be an ideal material for spinal cord tissue engineering. © 2015, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.