Tianjin Key Laboratory of Neurological Trauma Repair

Tianjin, China

Tianjin Key Laboratory of Neurological Trauma Repair

Tianjin, China
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Kong X.-B.,College of Logistics | Kong X.-B.,Tianjin University of Traditional Chinese Medicine | Tang Q.-Y.,Tianjin Key Laboratory of Neurological Trauma Repair | Chen X.-Y.,Tianjin Key Laboratory of Neurological Trauma Repair | And 3 more authors.
Neural Regeneration Research | Year: 2017

Polyethylene glycol is a synthetic, biodegradable, and water-soluble polyether. Owing to its good biological and material properties, polyethylene glycol shows promise in spinal cord tissue engineering applications. Although studies have examined repairing spinal cord injury with polyethylene glycol, these compelling findings have not been recently reviewed or evaluated as a whole. Thus, we herein review and summarize the findings of studies conducted both within and beyond China that have examined the repair of spinal cord injury using polyethylene glycol. The following summarizes the results of studies using polyethylene glycol alone as well as coupled with polymers or hydrogels: (1) polyethylene glycol as an adjustable biomolecule carrier resists nerve fiber degeneration, reduces the inflammatory response, inhibits vacuole and scar formation, and protects nerve membranes in the acute stage of spinal cord injury. (2) Polyethylene glycol-coupled polymers not only promote angiogenesis but also carry drugs or bioactive molecules to the injury site. Because such polymers cross both the blood-spinal cord and blood-brain barriers, they have been widely used as drug carriers. (3) Polyethylene glycol hydrogels have been used as supporting substrates for the growth of stem cells after injury, inducing cell migration, proliferation, and differentiation. Simultaneously, polyethylene glycol hydrogels isolate or reduce local glial scar invasion, promote and guide axonal regeneration, cross the transplanted area, and re-establish synaptic connections with target tissue, thereby promoting spinal cord repair. On the basis of the reviewed studies, we conclude that polyethylene glycol is a promising synthetic material for use in the repair of spinal cord injury. © 2017, Medknow Publications. All rights reserved.


Lu L.,Tianjin University of Traditional Chinese Medicine | Lu L.,Tianjin Key Laboratory of Neurological Trauma Repair | Chen X.-Y.,Tianjin Key Laboratory of Neurological Trauma Repair | Chen X.-Y.,Tianjin University | And 8 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2016

BACKGROUND: Skull repair materials cannot only restore the normal shape of the skull, but also play an important role in brain functional recovery. OBJECTIVE: To summarize the research status of polyetheretherketone (PEEK), titanium alloy and tissue engineering technique in cranioplasty and the prospect of three-dimensional (3D) printing technology. METHODS: Literatures related to skull repair materials were retrieved in databases of CNKI and PubMed published from 1995 to 2016, using the keywords of “bone regeneration material in calvarial, 3d printing bone scaffold” in Chinese and English, respectively. RESULTS AND CONCLUSION: Although titanium and PEEK have been used in clinic, titanium holds conductivity, thermal conductivity, while PEEK that may be displaced or lost is not involved in osseointegration. Tissue engineering technology participates in the skull tissue reconstruction, achieving satisfactory repair outcomes, but the problems of scaffold selection and preparation, seed cell obtainment, and growth factor release need to be overcomed. 3D printing technology can print personalized shape, fit the defect precisely, but the raw materials should have good biocompatibility and biomechanical property. Combination of tissue engineering technology with 3D printing technology shows a broad prospect in cranioplasty. © 2016, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.


Li Y.-P.,Tianjin University of Traditional Chinese Medicine | Chen X.-Y.,Tianjin Key Laboratory of Neurological Trauma Repair | Chen X.-Y.,Tianjin University | Chen X.-Y.,College of Logistics | And 7 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2015

BACKGROUND: Acellular spinal cord matrix material for framework of spinal cord scaffold has been shown to restore the neurologic function of the damaged spinal cord completely or partially. OBJECTIVE: To introduce the preparation and biological characteristics of acellular matrix scaffold for the spinal cord and to do an overview of its application and progress in spinal cord tissue engineering. METHODS: A computer-based search of CNKI and PubMed was performed for articles related to acellular spinal cord scaffolds published from January 2005 to October 2014. The keywords were “acellular spinal cord; scaffold; spinal cord injury; tissue engineering” in Chinese and English, appearing in the title and abstract. RESULTS AND CONCLUSION: The acellular spinal cord scaffold has low antigenicity, excellent biocompatibility and three-dimensional scaffold structure similar to the spinal cord, but it also possesses poor mechanical properties and structural instability. The scaffold modified by genipin and glutaraldehyde as cross-linking agents can be significantly improved in the biological performance. Currently, there are some explorations on the application of acellular spinal cord scaffold in nerve repair and regeneration, which lays a foundation for spinal cord tissue engineering. As its lots of advantages, the acellular spinal cord matrix material is expected to be an ideal material for spinal cord tissue engineering. © 2015, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.

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