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Zhang W.,Tianjin University | Lu Y.,Tianjin University | Wu L.,Tianjin University | Gao F.,Tianjin University | And 3 more authors.
Guangxue Xuebao/Acta Optica Sinica | Year: 2013

A time-resolved hemoglobin-diffuse optical tomography (DOT) system is proposed for the early breast tumor optical measurements, which is developed to produce functional images of the female breast. The system applies time-correlated single photon counting method to acquire the time-resolved light distributions of the light re-emissions from the boundaries. To keep the balance between detection time and hardware cost, a combined framework made up of four-channel parallel-detecting module and optical switches is used, which could decrease the influence of channels' attenuation differences and reduce the interference arising from the artifacts. The simultaneous reconstructions of the two optical (absorption and scattering) properties are achieved with the respective featured-data algorithms based on the generalized pulse spectrum technique. The performances of the methodology are assessed on breast-mimicking phantom and pilot experiments. The results demonstrate the efficacy of the hemoglobin-DOT for breast tumor diagnosis that the optical parameters can be reconstructed simultaneously, and the corresponding function information is useful for early breast tumor diagnosis. Source

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