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Zhao G.,Tianjin Institute of PharmaceuticalResearch | Lou Y.,Qingdao University of Science and Technology | Zhang L.,Qingdao University of Science and Technology | Shao H.,Tianjin Institute of PharmaceuticalResearch | And 3 more authors.
Synthetic Communications | Year: 2012

(Chemical Equation Presented) Total synthesis of α-elvucitabine was achieved in 26% overall yield by a concise nine-step procedure starting from L-lyxose, with trimethylsilyl trifluoromethaneoulfonate (TMSOTf)-mediated stereocontrolled α-N-glycosidation and olefination through Barton-McCombie deoxygenation being the key steps, and the stereochemistry of the product was determined by nuclear Overhauser effect spectroscopy. Copyright © Taylor & Francis Group, LLC. Source

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