Zhao G.,Tianjin Institute of PharmaceuticalResearch |
Lou Y.,Qingdao University of Science and Technology |
Zhang L.,Qingdao University of Science and Technology |
Shao H.,Tianjin Institute of PharmaceuticalResearch |
And 3 more authors.
Synthetic Communications | Year: 2012
(Chemical Equation Presented) Total synthesis of α-elvucitabine was achieved in 26% overall yield by a concise nine-step procedure starting from L-lyxose, with trimethylsilyl trifluoromethaneoulfonate (TMSOTf)-mediated stereocontrolled α-N-glycosidation and olefination through Barton-McCombie deoxygenation being the key steps, and the stereochemistry of the product was determined by nuclear Overhauser effect spectroscopy. Copyright © Taylor & Francis Group, LLC.