Tianjin Hemay Bio Technology Co.

Tianjin, China

Tianjin Hemay Bio Technology Co.

Tianjin, China
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Patent
TIANJIN HEMAY BIO Technology CO., TIANJIN MICHELE Science and Technology DEVELOPMENT CO. | Date: 2017-03-24

Disclosed is a compound of formula (I), wherein


Patent
Tianjin Hemay Bio Technology Co. | Date: 2015-01-14

Disclosed are a compound represented by formula (I) and a pharmaceutically acceptable salt thereof,^(1), R^(2), R^(3), R^(4), R^(5), W, n are defined as in the present application.


Patent
Tianjin Hemay Bio Technology Co. | Date: 2015-06-16

This invention is directed to derivatives of piperidine-2,6-dione, or their organic or inorganic salts thereof, a methods of synthesis of these derivatives, and their application as active pharmaceutical ingredient as inhibitors of TNF releasing in cells, the derivative of piperidine-2,6-dione being of the general formula (I): wherein n represents 1, 2, 3, 4, 5 or 6; R^(1 )represents from one to four of the same or different substituents selected from F, Cl, Br, C_(1-4 )alkyl, OH, OC_(1-4 )alkyl, NO_(2), NHC(O)C_(1-4 )alkyl, NH_(2), NH(C_(1-4 )alkyl), N(C_(1-4 )alkyl)_(2); R^(2 )represents OR^(3), NR^(3)R^(4), N(R^(3))COR^(4), O_(2)CR^(5); R^(3 )and R^(4 )represent independently and at each occurrence H or C_(1-4 )alkyl; R^(5 )represents CHR^(6)NR^(7)R^(8), CHR^(6)NR^(9)C(O)CHR^(10)NR^(7)R^(8), a heterocycle W or CHR^(6)NR^(9)C(O)W; R^(6), R^(9), R^(10 )represent independently and at each occurrence H, or C_(1-4 )alkyl; R^(7 )and R^(8 )represent independently and at each occurrence H, C_(1-4 )alkyl, or R^(7 )and R^(8 )taken together represent 1,3-propylene, 1,4-butylene, 1,5-pentylene, or 1,6-hexylene; W represents four-membered, five-membered, six-membered, seven-membered, or eight-membered saturated or unsaturated heterocycle.


Patent
Tianjin Hemay Bio Technology Co. | Date: 2013-07-05

Preparation methods of mesylate, para-toluenesulfonate, succinate, tartrate, sulphate, nitrate, phosphate, salicylate, fumarate, maleate, gallate, acetylsalicylate, benzenesulphonate, citrate, aspartate, glutaminate, lactate, gluconate, ascorbate, malonate, malate, sorbate, acetate or formate of 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine (i.e., Donepezil). Novel polymorphs formed from these salts and their preparation methods. Co-crystals formed from Donepezil hydrochloride and maleic acid, fumaric acid, citric acid, salicylic acid, tartaric acid or succinic acid.


Patent
Tianjin Hemay Bio Technology Co., Tianjin Michele Science and Technology Development Co. | Date: 2013-08-14

Provided are polymorphs I to VIII of a dalfampridine or of its solvates, a preparation method therefore, and applications thereof as an active component of a medicine. Said polymorphs I to VIII of the dalfampridine or of its solvents can be used to prepare formulations for improving the walking speed of patients of multiple sclerosis and for alleviating other symptoms of multiple sclerosis.


Patent
Tianjin Hemay Bio Technology Co. | Date: 2013-12-18

This invention is directed to derivatives of piperidine-2,6-dione, or their organic or inorganic salts thereof, a methods of synthesis of these derivatives, and their application as active pharmaceutical ingredient as inhibitors of TNF releasing in cells, the derivative of piperidine-2,6-dione being of the general formula (I): wherein n represents 1, 2, 3, 4, 5 or 6; R^(1 )represents from one to four of the same or different substituents selected from F, Cl, Br, C_(1-4 )alkyl, OH, OC_(1-4 )alkyl, NO_(2), NHC(O)C_(1-4 )alkyl, NH_(2), NH(C_(1-4 )alkyl), N(C_(1-4 )alkyl)_(2); R^(2 )represents OR^(3), NR^(3)R^(4), N(R^(3))COR^(4), O_(2)CR^(5); R^(3 )and R^(4 )represent independently and at each occurrence H or C_(1-4 )alkyl; R^(5 )represents CHR^(6)NR^(7)R^(8), CHR^(6)NR^(9)C(O)CHR^(10)NR^(7)R^(8), a heterocycle W or CHR^(6)NR^(9)C(O)W; R^(6), R^(9), R^(10 )represent independently and at each occurrence H, or C_(1-4 )alkyl; R^(7 )and R^(8 )represent independently and at each occurrence H, C_(1-4 )alkyl, or R^(7 )and R^(8 )taken together represent 1,3-propylene, 1,4-butylene, 1,5-pentylene, or 1,6-hexylene; W represents four-membered, five-membered, six-membered, seven-membered, or eight-membered saturated or unsaturated heterocycle.


Patent
Tianjin Hemay Bio Technology Co. | Date: 2015-10-12

Disclosed is a compound of formula I, a stereoisomer thereof, a cis-trans-isomer thereof, a tautomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, a solvate thereof or a prodrug thereof,


Patent
Tianjin Hemay Bio Technology Co., Tianjin Michele Science and Technology Development Co. | Date: 2013-09-04

Disclosed are a polymorphs I-VI of N-(6-(4-chlorophenoxy)hexyl)-N-cyano-N-(4-pyridyl)guanidine or of a solvate thereof, a preparation method thereof, and a use thereof as a biological active ingredient. The polymorphs are useful in treatment of cancers, and diseases or disorders caused by abnormal cell proliferation.


Patent
TIANJIN HEMAY BIO Technology CO., TIANJIN MICHELE Science and Technology DEVELOPMENT CO. | Date: 2014-05-19

Disclosed is a compound of formula (I), wherein


Patent
Tianjin Hemay Bio Technology Co. | Date: 2013-04-17

Disclosed is a compound of formula I, a stereoisomer thereof, a cis-trans-isomer thereof, a tautomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, a solvate thereof or a prodrug thereof,^(1), R^(2), R^(3) and R^(4) are each as defined in the present application.

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