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Zhang H.,Tianjin Medical University | Xia H.,Tianjin Haibin Peoples Hospital | Zhang L.,Tianjin Medical University | Zhang B.,Tianjin Medical University | And 2 more authors.
American Journal of Surgery | Year: 2015

Background Our aim was to determinate the prognostic value of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in primary operable patients with non-small cell lung cancer (NSCLC). Methods Six hundred seventy-eight NSCLC patients were enrolled in this study. The prognostic significance of both markers was determined by both univariate and multivariate Cox survival analysis. The cut-off value for NLR and PLR was selected by using receiver operating characteristic curve analysis. Results Multivariate analysis showed that NLR was an independent prognostic factor for disease-free survival (hazard ratio = 1.593, 95% confidence interval [CI] 1.277 to 1.988, P <.001) and overall survival (hazard ratio = 1.624, 95% CI 1.304 to 2.022, P <.001). The area under the curve was.640 (95% CI.599 to.682, P <.001) for NLR and.547 (95% CI.503 to.590, P =.036) for PLR, indicating that NLR was superior to PLR as a predictive factor in primary operable NSCLC patients. Conclusions Preoperative NLR represents a significant independent prognostic indicator in primary operable NSCLC patients. Our results also demonstrate that high-risk patients based on the NLR do not benefit from adjuvant chemotherapy. © 2015 Elsevier Inc. All rights reserved.

Wang J.,Tianjin Medical University | Bai L.,Tianjin Medical University | Shi M.,Tianjin Medical University | Yang L.,Tianjin Medical University | And 7 more authors.
Stroke | Year: 2016

Background and Purpose-We investigated secular trends in the age of stroke onset and stroke incidence in a low-income population in rural China. Methods-The study population was recruited from a population-based stroke surveillance study conducted in a township in Tianjin, China, from 1992 to 2014. The trends in mean age and incidence of first-ever stroke were assessed by sex and stroke subtype. Risk factor surveys were conducted in the same population in both 1991 and 2011. Results-A total of 1053 patients experienced first-ever stroke from 1992 to 2014. The mean age of stroke onset in men significantly decreased by 0.28 years annually overall, by 0.56 years for intracerebral hemorrhage, and by 0.22 years for ischemic stroke (P<0.05). However, a similar trend was not observed in women. The age-standardized first-ever stroke incidence in the same population significantly increased across sex and stroke subtypes, increased by 6.3% overall, 5.5% for men, 7.9% for women, 4.6% for intracerebral hemorrhage, and 7.3% for ischemic stroke (P<0.05) during 1992 to 2014. Concurrently, the prevalence of hypertension, diabetes mellitus, obesity, current smoking, and alcohol consumption increased significantly in young and middle-aged adults from 1991 to 2011. Conclusions-The age of stroke onset tends to be younger among low-income population in China after the dramatic increased incidence of stroke during the gradual extension of life expectancy of population in China. These findings suggested that stroke burden will continue to increase in the long time, unless the risk factors in low-income populations are effectively controlled. © 2016 American Heart Association, Inc.

Cai H.,Tianjin Medical University | Wu Q.-J.,Tianjin Medical University | Zhu Y.-X.,Tianjin Haibin Peoples Hospital | Zhao W.,Tianjin Medical University | And 2 more authors.
Chinese Journal of Contemporary Neurology and Neurosurgery | Year: 2014

Objective: To study the effect of epileptic neuron model after transfection of microRNA (miRNA) - 212 on brain - derived neurotrophic factor (BDNF)/tyrosine protein kinase B (TrkB) signaling pathway.Methods: The primary rat hippocampal neurons were cultivated in vitro for 7 d and were randomly divided into 8 groups: control group, epilepsy group, control + BDNF group, epilepsy + BDNF group, control + miRNA - 212 group, epilepsy + miRNA - 212 group, control + miRNA - 212 + BDNF group, epilepsy + miRNA-212 + BDNF group. Epilepsy model of hippocampal neurons were established by being exposed to Mg2+ free extracellular fluid for 3 h. And then the neurons were put back into the normal extracellular fluid of magnesium for 2 h and slow virus diluent was dropwise added for transfection, so that miRNA-212 lentiviral vector was structured. Protein was extracted after 48-72 h. BDNF was added into media 10 min before protein was extracted. Immunofluoresence double staining, patch clamp technique and Western blotting were used to observe the effect of miRNA - 212 transfection on BDNF/TrkB signaling pathway.Results: After BDNF was injected, compared with the control group and epilepsy group, the phosphorylated TrkB (pTrkB)/TrkB value was significantly higher in control + BDNF group and epilepsy + BDNF group (P = 0.001), suggesting the BDNF/TrkB signaling pathway was activated. After transfection of miRNA-212, the pTrkB/TrkB value in epilepsy + miRNA-212 + BDNF group was significantly lower than that in epilepsy + BDNF group (P = 0.001), suggesting the BDNF/TrkB signaling pathway was suppressed.Conclusions: When hippocampal neurons were transfected miRNA-212, the BDNF/TrkB signaling pathway was suppressed, but BDNF could activate the BDNF/TrkB signaling pathway. ©, 2014, Tianjin Huanhu Hospital. All right reserved.

Li D.,Tianjin Medical University | Cai H.,Tianjin Medical University | Wu Q.-J.,Tianjin Medical University | Zhu Y.-X.,Tianjin Haibin Peoples Hospital | And 3 more authors.
Chinese Journal of Contemporary Neurology and Neurosurgery | Year: 2014

Background: Epilepsy is a chronic neurological condition characterized by paroxysm of seizures due to abnormal electrical discharge from central nervous system neurons. Several new antiepileptic drugs (AEDs) were listed over the past two decades, and they were believed to be equally effective and have better tolerability and side effect profiles. This paper aims to evaluate the efficacy and safety of adjunctive topiramate in refractory partial seizures.Methods: Relevant research articles about randomized controlled trials of adjunctive topiramate in refractory partial seizures, with topiramate, Topamax, add - on treatment, adjunctive treatment, add - on therapy, adjunctive therapy, refractory partial seizure, refractory partial epilepsy both in Chinese and English as retrieval words, were retrieved from PubMed (1995-2014), Cochrane Central Register of Controlled Trials (CENTRAL, 1995-2014), The Cochrane Database of Systematic Reviews (CDSR, 1995-2014), China National Knowledge Infrastructure (CNKI, 1995-2014) and Wanfang Data (1999-2014). Two reviewers independently evaluated the quality of the included articles and abstracted the data. A Meta-analysis was conducted using RevMan 5.0 software.Results: According to the enrollment criteria, 13 prospective, randomized controlled clinical trials with a total of 1622 patients were finally selected. The proportions of patients with reduction in seizure frequency ≥ 50% (OR = 3.710, 95% CI: 2.870-4.810; P = 0.000), ≥ 75% (OR = 7.220, 95% CI: 3.310-15.750; P = 0.000) and seizure free (OR = 3.380, 95%CI: 1.720-6.640; P = 0.000) in topiramate group were significantly higher than that in control group. The treatment withdrawal ratio was significantly higher compared to placebo in 600 mg/d and 800 mg/d subgroups, but not in 200 mg/d subgroup (200 mg/d: OR = 2.170, 95%CI: 0.470-9.950, P = 0.320; 600 mg/d: OR = 2.090, 95%CI: 1.020-4.270, P = 0.040; 800 mg/d: OR = 8.000, 95%CI:1.390-46.140, P = 0.020). The common side effects included somnolence, anorexia, ataxia, aprosexia, dizziness, fatigue, nausea, thinking abnormality, paraesthesia and weight loss. The occurrence rate of side effects in topiramate group was higher than that in control group.Conclusions: Topiramate is effective when added to existing therapy in patients with refractory partial seizures. The withdrawal rate of 200 mg/d topiramate is similar to control group. Compared with the control group, adverse effects are more common but mild or moderate, mainly related with the central nervous system. However, trials included in this study are of relatively short duration, and provide no evidence for the long-term efficacy of topiramate. ©, 2014, Tianjin Huanhu Hospital. All right reserved.

Li B.,Tianjin Haibin Peoples Hospital | Lou Y.,Tianjin Haibin Peoples Hospital | Gu H.,Tianjin Haibin Peoples Hospital | Long X.,Tianjin Haibin Peoples Hospital | And 5 more authors.
PLoS ONE | Year: 2015

Objectives The incidence of ischemic stroke has increased and that of hemorrhagic stroke has decreased in urban China; however, the trends in rural areas are unknown. We aimed to explore the secular trends in incidence and transition of stroke subtypes among rural Chinese. Methods This was a population-based stroke surveillance through the Tianjin Brain Study. A total of 14,538 residents in a township of Ji County in Tianjin, China participated in the study since 1985. We investigated the age-standardized stroke incidence (sex-specific, type-specific, and age-specific), the annual proportion of change in the incidence of stroke, and the proportion of intracerebral hemorrhage in the periods 1992-1998, 1999-2005, and 2006- 2012, because the neuroimaging technique was available since 1992 in this area. Results The age-standardized incidence per 100,000 person-years increased significantly for both intracerebral hemorrhage (37.8 in 1992-1998, 46.5 in 1999-2005, and 76.5 in 2006-2012) and ischemic stroke (83.9 in 1992-1998, 135.3 in 1999-2005, and 238.0 in 2006-2012). The age-standardized incidence of first-ever stroke increased annually by 4.9% for intracerebral hemorrhage and by 7.3% for ischemic stroke. The greatest increase was observed in men aged 45-64 years for both stroke types (P < 0.001). The proportion of intracerebral hemorrhage was stable overall, increased among men aged 45-64 years, and decreased among men aged ≥65 years. The average age of intracerebral hemorrhage in men reduced by 7.5 years from 1992 to 2012. Conclusion The age-standardized incidence of main stroke subtypes increased significantly in rural China over the past 21 years; the overall proportion of intracerebral hemorrhage was stable, but the incidence increased significantly among middle-Aged men. These findings imply that it is crucial to control stroke risk factors in middle-Aged men for stroke prevention in future decades. Copyright: © 2015 Li et al.

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