PubMed | Affiliated Hospital of Chinese Peoples Armed Police Forces Logistics Institute Tianjin 300100, Tianjin Medical University and Tianjin Eye Hospital Tianjin 300020
Type: Journal Article | Journal: International journal of clinical and experimental medicine | Year: 2015
Vitamin E -tocotrienol has been reported to possess anticancer activity both in vitro and in vivo. However, the underlying molecular mechanisms of -tocotrienol induced apoptosis in triple-negative breast cancer are not fully understood. Here, we reported that microRNA-429 (miR-429) is up-regulated in two TNBC cell lines (MDA-MB-231 and MDA-MB-468), treated with -tocotrienol. Inhibition of miR-429 may partially rescue the apoptosis induced by -tocotrienol in MDA-MB-231 cells. We also showed that the forced expression of miR-429 was sufficient to lead to apoptosis in MDA-MB-231 cells. Furthermore, we identified X-linked inhibitor of apoptosis protein (XIAP) as one of miR-429s target genes. These results suggest that the activation of miR-429 by -tocotrienol may be an effective approach for the prevention and treatment of triple-negative breast cancer.