Xing A.-W.,Hainan Province Peoples Hospital |
Zhang H.,Obstetrics and Gynecology Hospital of Tianjin Center
Chinese Journal of Cancer Prevention and Treatment | Year: 2010
OBJECTIVE: To study the relationship among FAS, FASL and ovarian epithelial carcinoma. METHODS: Ten samples of normal ovarian tissues, 30 samples of benign epithelial ovarian tumors, 32 samples of bordline epithelial ovarian tumors and 52 samples of epithelial ovarian carcinomas were examined for the expressions of FAS and FASL by SP immunohistochemistry, and a analysis was conducted of the two in the ovarian epithelial tumors pathogenesis function. RESULTS: The expression of FAS in epithelial ovarian carcinoma was significantly lower than that in the borderline ovarian tumors, the benign epithelial ovarian tumors and the normal ovary tissues. The difference was significant (H = 20.784, P<0.001), but the expression of FAS in normal ovary tissues, benign ovary tumors, borderline ovary tumors was non-statistically significant (P>0.05). The expression of FASL in epithelial ovarian carcinomas was significantly stronger than that in normal tissues and benign epithelial ovarian tumors. The difference had a statistical significance (P<0.05), but the expression of FASL in normal tissues, borderline and benign epithelial ovarian tumors was non-statistically significant (P>0.05). CONCLUSIONS: The down-regulation of FAS expression and up-regulation of FASL expression exist in ovarian epithelial carcinoma. FAS may be in coordination with FASL in carcinogenesis and progression of epithelial ovarian tumors.