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Tianjin, China

Gao J.,Zhejiang Traditional Chinese Medical Hospital | Li Y.,Oxford Genetics | Cai Y.,Fudan University | Chen J.,Shanghai JiaoTong University | And 34 more authors.
Psychological Medicine

Background In Western countries, a history of major depression (MD) is associated with reports of received parenting that is low in warmth and caring and high in control and authoritarianism. Does a similar pattern exist in women in China?Method Received parenting was assessed by a shortened version of the Parental Bonding Instrument (PBI) in two groups of Han Chinese women: 1970 clinically ascertained cases with recurrent MD and 2597 matched controls. MD was assessed at personal interview.Results Factor analysis of the PBI revealed three factors for both mothers and fathers: warmth, protectiveness, and authoritarianism. Lower warmth and protectiveness and higher authoritarianism from both mother and father were significantly associated with risk for recurrent MD. Parental warmth was positively correlated with parental protectiveness and negatively correlated with parental authoritarianism. When examined together, paternal warmth was more strongly associated with lowered risk for MD than maternal warmth. Furthermore, paternal protectiveness was negatively and maternal protectiveness positively associated with risk for MD.Conclusions Although the structure of received parenting is very similar in China and Western countries, the association with MD is not. High parental protectiveness is generally pathogenic in Western countries but protective in China, especially when received from the father. Our results suggest that cultural factors impact on patterns of parenting and their association with MD. © Cambridge University Press 2011. Source

Zhang J.-R.,Tianjin Anding Hospital | Sun D.-L.,Tianjin Anding Hospital | Shi J.-J.,Tianjin University of Traditional Chinese Medicine | Zhao J.-M.,Chinese Academy of Sciences
Chinese Journal of New Drugs

Objective: To investigate the effect of daidzein isoflavone on the behaviors of chronic unpredicted mild stress (CUMS)-induced depression in rats and the possible underlying mechanism. Methods: Fifty male Sprague-Dawley (SD) rats were divided into five groups. They were exposed CUMS for 21 consective days, and treated with double distilled water (control), daidzein (10 and 30 mg·kg-1 per day), or duloxetine hydrochloride (DH, 10 mg·kg-1 per day). Behaviors after CUMS protocol were assessed by open field test, sucrose intake test and novelty-suppressed feeding test (NSFT) in all the rats. Serum adrenocorticotropic hormone (ACTH) and corticosterone (CORT) were detected by ELISA. The morphology of adrenal tissue were studied by HE staining. Results: Compared with the normal rats, sucrose preference, crossing and rearing were reduced in the CUMS groups (P<0.01), while the above indicators were increased in rats treated with daidzein (10 and 30 mg·kg-1, P<0.01) and DH (P<0.05) compared with CUMS control. Compared with the DH group, daidzein 10 mg·kg-1 did not affect (P>0.05), but 30 mg·kg-1 significantly increased the crossing and rearing (P<0.01). The CUMS rats had greater latencies to commence feeding in the NSFT than the control rats (P<0.01). Daidzein (10 and 30 mg·kg-1) and DH significantly reduced the latencies compared with the CUMS control (P<0.01~0.05). No significant differences were found among daidzein (10 and 30 mg·kg-1) and DH groups (P>0.05). Compared with the normal rats, the serum ACTH and CORT contents were significantly increased in the CUMS rats (P<0.01). Daidzein (10 and 30 mg·kg-1) and DH markedly decreased the contents compared with the CUMS control (P<0.01). No significant differences were found among daidzein (10 and 30 mg·kg-1) and DH groups (P>0.05). Conclusion: Daidzein has a robust antidepressant-like effect on depression-associated behaviors in CUMS rats, and the underlying mechanisms could involve inhabiting function of HPA axis. ©, 2015, Chinese Journal of New Drugs Co. Ltd. All right reserved. Source

Li H.,Shanghai Mental Health Center | Yao C.,Peking University | Shi J.,Xian Mental Health Center | Yang F.,Beijing HuiLongGuan Hospital | And 12 more authors.
Journal of Psychiatric Research

This randomized, double-blind study compared the efficacy and safety of blonanserin and risperidone to treat Chinese schizophrenia patients aged ≥18 and < 65 years. Patients with Positive and Negative Syndrome Scale (PANSS) total scores ≥70 and ≤ 120 were randomized to receive blonanserin or risperidone using a gradual dose-titration method (blonanserin tablets: 8-24 mg/day; risperidone tablets: 2-6 mg/day), twice daily. Treatment populations consisted of 128 blonanserin-treated patients and 133 risperidone-treated patients. Intention-to-treat analysis was performed using the last observation carried forward method. Reductions of PANSS total scores by blonanserin and risperidone treatment were -30.59 and -33.56, respectively. Risperidone treatment was associated with elevated levels of serum prolactin (67.16% risperidone versus 52.31% blonanserin) and cardiac-related abnormalities (22.39% risperidone versus 12.31% blonanserin), and blonanserin patients were more prone to extrapyramidal side effects (48.46% blonanserin versus 29.10% risperidone). In conclusion, blonanserin was as effective as risperidone for the treatment of Chinese patients with schizophrenia. The overall safety profiles of these drugs are comparable, although blonanserin was associated with a higher incidence of EPS and risperidone was associated with a higher incidence of prolactin elevation and weight gain. Thus, blonanserin is useful for the treatment of Chinese schizophrenia patients. © 2015 The Authors. Source

Liu H.,Central South University | Yin H.-F.,Tianjin Anding Hospital | Wu D.-X.,Central South University | Xu S.-J.,Central South University

Background: Dysfunctional cognitive processing and abnormal brain activation in response to emotional stimuli have long been recognized as core features of the major depressive disorder (MDD). The aim of this study was to examine how Chinese patients with MDD process Chinese emotional words presented to either the left (LH) or right hemisphere (RH).Methods: Reaction time (RT) and the late positive component of the event-related potential were measured while subjects judged the valence (positive or negative) of emotional words written in Chinese.Results: Compared to healthy controls, patients with MDD exhibited slower RTs in response to negative words. In all subjects, the RTs in response to negative words were significantly faster than RTs in response to positive words presented to the LH, as well as significantly faster than responses to negative words presented to the RH. Compared to healthy controls, MDD patients exhibited reduced activation of the central and left regions of the brain in response to both negative and positive words. In healthy controls, the posterior brain areas were more active than the anterior brain areas when responding to negative words.Conclusion: All individuals showed faster RTs in response to negative words compared to positive words. In addition, MDD patients showed lateralization of brain activity in response to emotional words, whereas healthy individuals did not show this lateralization. Posterior brain areas appear to play an especially important role in discriminating and experiencing negative emotional words. This study provides further evidence in support of the negative bias hypothesis and the emotional processing t heory. © 2014 S. Karger AG, Basel. Source

Zhen Z.,Chinese Academy of Sciences | Chang B.,Chinese Academy of Sciences | Li M.,Chinese Academy of Sciences | Lian F.-M.,Chinese Academy of Sciences | And 9 more authors.
American Journal of Chinese Medicine

The Chinese formula Tang-Min-Ling (TML), an improved product of the decoction of Dachaihu which has a history of more than 2000 years, has main constituents of Coptis chinensis Franch, Scutellaria baicalensis Georgi, Rheum officinale Baill and Bupleurum chinense DC. A multi-central randomized controlled investigation performed previously by us has showed that TML has positive effects on regulating glycometabolism in type 2 diabetes (T2DM) patients, but the mechanisms remain unclear. Using Otsuka Long-Evans Tokushima Fatty (OLETF) rats as an animal model with rosiglitazone as a positive control, we were able to detect TML's effect on the serum glucose, serum lipid, serum leptin and adiponcetin after oral administration for 12 weeks. We were also able to detect the insulin resistance level by a glucose clamp test and study the mechanisms of TML in improving insulin resistance by detecting skeletal muscle AMP-activated protein kinase (AMPK) and glucose transporter 4 (GLUT4). Results showed that TML significantly reduced the glucose area under a curve of the oral glucose tolerance test, and had a positive effect in regulating serum lipid metabolism. TML treatment also significantly reduced the serum leptin level, but it had no effect on the serum adiponectin level. The AMPK enzymatic activity and GLUT4 expression in Skeletal Muscle were also upregulated in the TML group. The results suggest that the Chinese medicine TML, which contains Coptis chinensis Franch as one of its components, improves glycometabolism and its possible mechanisms may involve in improvement of insulin resistance of OLETF rats. © 2011 World Scientific Publishing Company & Institute for Advanced Research in Asian Science and Medicine. Source

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