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Hou Z.-P.,Tianjin Agriculture Academy | Wang W.-J.,Tianjin Agriculture Academy | Liu J.-X.,Tianjin Agriculture Academy | Liu G.,CAS Institute of Subtropical Agriculture | And 4 more authors.
Journal of Food, Agriculture and Environment | Year: 2011

Forty-eight German Landrace weaned pigs were used in this study to investigate the effects of Lfcin B and Cec P1 on performance, faecal score and DM of weaned piglets orally challenged with enterotoxigenic Escherichia coli F4. The piglets were assigned randomly into four groups: Control, enterotoxigenic Escherichia coli F4ac (ETEC), enterotoxigenic Escherichia coli F4ac (ETEC)+lactoferricin B (Lfcin B) and enterotoxigenic Escherichia coli F4ac (ETEC) +Cecropin P1 (Cec P1) on the basis of weight and litter. All piglets in three experimental groups were orally challenged with 3x109 cfu E.coli K88 O149:K91:F4ac on d 29 and 30. Lfcin B and Cec P1 were administered orally as a single dose of 2 mg per piglet on d 29 after being challenged ETEC F4ac 3 hours later. From the age of 30 days, the piglets were offered feed and water ad libitum. The results showed that there were no significant differences on daily weight, ADG and ADFI (P>0.05) of piglets among the four groups during the experimental period. From d 28 to 35, the piglets in Cec P1 groups kept higher daily weight (p>0.05) than those in other three groups. There were no differences for faecal score and feces dry matter among the four groups. But there was a tendency piglet in Cec P1 group kept the balance of faecal score and feces dry matter. Though there are no obvious effects, Lfcin B and Cec P1 have potential use without toxicity in vivo as additive in the husbandry product. Source


Hou Z.-P.,Tianjin Agriculture Academy | Wang W.-J.,Tianjin Agriculture Academy | Liu Z.-Q.,CAS Institute of Subtropical Agriculture | Liu G.,CAS Institute of Subtropical Agriculture | And 2 more authors.
Journal of Food, Agriculture and Environment | Year: 2011

Enterotoxigenic Escherichia coli (ETEC) is one of the most important causes of diarrhea in pigs, especially in postweaning piglets throughout the world. Natural products are the major source of leading compounds for drugs against pathogens. Antimicrobial peptides (AMPs) are small, endogenous, polycationic molecules that constitute a ubiquitous and significant component of innate immunity. In this study, we used two kinds of AMPs - lactoferricin B (Lfcin B) and cecropin P1 (Cec P1) to against ETEC. The results showed that Lfcin B and Cec P1 could effectively inhibit the growth of ETEC in vitro. Minimum Inhibition Concentration (MIC) and Minimum Effect Concentration (MEC) of Lfcin B are 0.8 and 1 μg/ml, respectively. MIC and MEC for Cec P1 are the same, which is 0.6 μg/ml. The results suggested that Cec P1 was more effective than Lfcin B but there was no statistically significant difference. Source

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