Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital Tianjin 300120

Tianjin, China

Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital Tianjin 300120

Tianjin, China
SEARCH FILTERS
Time filter
Source Type

PubMed | Tianjin Hospital Tianjin 300211, The Affiliated Hospital of CPAP of Logistic College Tianjin 300162 and Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital Tianjin 300120
Type: Journal Article | Journal: International journal of clinical and experimental medicine | Year: 2016

Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) and the stimulation of platelet-derived growth factor (PDGF)-BB play major pathological processes involved in the development of cardiovascular diseases. As a result, the use of anti-proliferative and anti-migratory agents for VSMCs offers promise for the treatment of vascular disorders. Myricitrin is a naturally occurring phenolic compound which possesses antioxidant and anti-inflammatory activity. In this study, we investigate the inhibitory effect of myricitrin on PDGF-BB-induced VSMCs proliferation and migration. In accordance with these findings, myricitrin induced the arrest of cell cycle progression at G0/G1 phase. Myricitrin also decreased the expressions of G0/G1 specific regulatory proteins including cyclin D1, cyclin-dependent kinases (CDK) 4, cyclin E and CDK2, as well as increased the expression of p21 in PDGF-BB-induced VSMCs. Moreover, myricitrin inhibited PDGF-BB-induced phosphorylation of PDGFR, Akt and Erk1/2. These results suggest that myricitrin plays an important role in prevention of VSMCs proliferation and migration through the G0/G1 cell cycle arrest by PDGF signaling pathway. Thus, myricitrin is effective in reducing atherosclerotic process by blocking proliferation of VSMCs.

Loading Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital Tianjin 300120 collaborators
Loading Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital Tianjin 300120 collaborators