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Chapel Hill, NC, United States

Jordan J.M.,Thurston Arthritis Research Center
Aging Health | Year: 2013

Joanne M Jordan, MD MPH, received her undergraduate education at Cornell University (NY, USA); her medical education at The Johns Hopkins Medical Institutions (MD, USA); and her masters in public health at the University of North Carolina School of Public Health (NC, USA). She received training in internal medicine and subspecialty training in rheumatology and immunology at Duke University Medical Center (NC, USA). She joined the faculty of the Division of Rheumatology, Allergy and Immunology at the University of North Carolina in 1987. She currently is the Chief of the Division of Rheumatology, Allergy and Immunology and the Director of the Thurston Arthritis Research Center at the University of North Carolina. Her research interests are in the epidemiology and genetics of osteoarthritis and disability. She is the principal investigator of the Johnston County Osteoarthritis Project, a large, >20-year, community-based prospective study of individuals aged 45 years and older. The study is the first of its type to include both African-Americans and Caucasians, and is unique in its inclusion of radiographic, serologic, genetic, and physical and functional phenotypic examinations of its participants for multiple chronic diseases. Dr Jordan currently serves as Chair of the US Bone and Joint Initiative's Chronic Osteoarthritis Management Initiative, whose goal is to change the medical paradigm regarding osteoarthritis by incorporating joint health assessment and management into routine medical care. She is the Deputy Editor for Clinical Science of the journal Osteoarthritis and Cartilage and is a member of the Board of Directors of the Osteoarthritis Research Society International. She is the recipient of the Osteoarthritis Research Society International's Clinical Research Award in 2007, the 2009 American College of Rheumatology Award of Distinction in Investigative Mentoring and the 2011 Rural Sociological Society's Distinguished Service to Rural Life Award. © 2013 Future Medicine Ltd. Source


Mielenz T.J.,Columbia University | Edwards M.C.,Ohio State University | Callahan L.F.,Thurston Arthritis Research Center
Journal of Aging and Physical Activity | Year: 2011

Benefits of physical activity for those with arthritis are clear, yet physical activity is difficult to initiate and maintain. Self-efficacy is a key modifiable psychosocial determinant of physical activity. This study examined two scales for self-efficacy for exercise behavior (SEEB) to identify their strengths and weaknesses using item response theory (IRT) from community-based randomized controlled trials of physical activity programs in adults with arthritis. The 2 SEEB scales included the 9-item scale by Resnick developed with older adults and the 5-item scale by Marcus developed with employed adults. All IRT analyses were conducted using the graded-response model. IRT assumptions were assessed using both exploratory and confirmatory factor analysis. The IRT analyses indicated that these scales are precise and reliable measures for identifying people with arthritis and low SEEB. The Resnick SEEB scale is slightly more precise at lower levels of self-efficacy in older adults with arthritis. © 2011 Human Kinetics, Inc. Source


Billard M.J.,Thurston Arthritis Research Center | Timoshchenko R.G.,Thurston Arthritis Research Center | McGinnis M.W.,Thurston Arthritis Research Center | Foreman O.,The Jackson Laboratory | And 3 more authors.
Molecular Immunology | Year: 2013

Polymorphism at the GPSM3 gene locus is inversely associated with four systemic autoimmune diseases, including rheumatoid arthritis and ankylosing spondylitis. G-protein signaling modulator-3 (GPSM3) expression is most pronounced in myeloid cells, in which it targets heterotrimeric G-protein Gαi subunits of chemokine receptors, critical to immune function. To begin to explore the regulatory role of GPSM3 in monocytes, human THP-1 and primary mouse myeloid cells were cultured under stimulus conditions; GPSM3 was found by immunoblotting to be expressed at highest levels in the mature monocyte. To evaluate the effects of GPSM3 deficiency on a myeloid-dependent autoimmune disease, collagen antibody-induced arthritis (CAIA) was induced in Gpsm3-/- and control mice, which were then analyzed for clinical score, paw swelling, intra-articular proinflammatory markers, and histopathology. Mice lacking GPSM3 were protected from CAIA, and expression of monocyte-representative pro-inflammatory chemokine receptors and cytokines in paws of Gpsm3-/- mice were decreased. Flow cytometry, apoptosis, and transwell chemotaxis experiments were conducted to further characterize the effect of GPSM3 deficiency on survival and chemokine responsiveness of monocytes. GPSM3-deficient myeloid cells had reduced migration ex vivo to CCL2, CX3CL1, and chemerin and enhanced apoptosis in vitro. Our results suggest that GPSM3 is an important regulator of monocyte function involving mechanisms of differentiation, survival, and chemotaxis, and deficiency in GPSM3 expression is protective in acute inflammatory arthritis. © 2012 Elsevier Ltd. Source


Shi X.A.,University of North Carolina at Chapel Hill | Renner J.B.,University of North Carolina | Kraus V.B.,University of North | Golightly Y.M.,Duke University | And 2 more authors.
Journal of Rheumatology | Year: 2014

Objective. To determine the associations between joint metabolism biomarkers and hand radiographic osteoarthritis [(rOA), based on Kellgren Lawrence (KL) grade = 2], symptoms, and function. Methods. Cross-sectional data were available for 663 participants (mean age 63 yrs, 63% white, 49% women). Three definitions of hand rOA were considered: (1) a composite measure involving at least 3 hand joints distributed bilaterally with 2 of 3 in the same joint group, including = 1 distal interphalangeal joint, without metacarpophalangeal (MCP) swelling; (2) rOA in at least 1 joint of a group; and (3) number of joints with KL = 2. We assessed hand symptoms and the 15-item Australian Canadian Hand Osteoarthritis Index (AUSCAN; Likert format). We measured serum cartilage oligomeric matrix protein (sCOMP), hyaluronic acid (sHA), carboxy-terminal propeptide of type II collagen, type II collagen degradation product, urinary C-terminal crosslinked telopeptide of type II collagen, and urinary N-terminal crosslinked telopeptide. Linear regression models were performed to assess associations between each biomarker with hand rOA, AUSCAN, and symptoms, adjusting for age, sex, race, current smoking/drinking status, body mass index, and hip and knee rOA. Results. In adjusted analyses, MCP (p < 0.0001) and carpometacarpal rOA (p = 0.003), and a higher number of hand joints with rOA (p = 0.009), were associated with higher levels of sHA. Positive associations were seen between AUSCAN and hand symptoms and levels of sCOMP (p = 0.003) and sHA (p = 0.048). Conclusion. Hand symptoms and higher AUSCAN scores were independently associated with higher levels of both sCOMP and sHA; hand rOA was associated only with sHA levels. © 2014. All rights reserved. Source


Golightly Y.M.,University of North Carolina at Chapel Hill | Allen K.D.,Duke University | Helmick C.G.,Centers for Disease Control and Prevention | Schwartz T.A.,Thurston Arthritis Research Center | And 3 more authors.
Journal of Rheumatology | Year: 2010

Objective. To examine the hazard of incident and progressive radiographic osteoarthritis (rOA) and chronic joint symptoms at the hip and knee by limb length inequality (LLI) in a large, community-based sample. Methods. A longitudinal cohort completed baseline (1991-97) clinical evaluation and identical followup assessment (1999-2003) (median followup time 5.9 yrs, range 3.0-13.1 yrs). LLI was defined at baseline as a measured difference between limbs ≥ 2 cm. The study groups with LLI data comprised 1583 participants with paired (baseline and followup) knee radiographs and 1453 participants with paired hip radiographs. Multivariable Cox regression models were used to examine the hazard of incident and progressive knee and hip rOA and chronic joint symptoms, with adjustment for demographic and clinical factors. Results. The hazard of developing incident knee or hip rOA was 20%-30% higher and of developing progressive knee or hip rOAwas 35%-83% higher among participants with LLI, but results were only statistically significant for progressive knee rOA (adjusted hazard ratio = 1.83, 95% CI 1.10-3.05). The hazards of progressive chronic knee symptoms and incident and progressive chronic hip symptoms were 13%-59% higher among participants with LLI, but were not statistically significant. Conclusion. LLI was associated with progressive knee rOA and was nonsignificantly associated with incident knee or hip rOA and progressive hip rOA, progressive chronic knee symptoms, and incident and progressive chronic hip symptoms. Longer studies may strengthen these associations and help determine whether LLI is a risk factor or marker of these outcomes. The Journal of Rheumatology Copyright © 2010. All rights reserved. Source

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