Waldenburg, Switzerland
Waldenburg, Switzerland

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Hinkle R.M.,250 West Bridge Street | Zeman P.,Thommen Medical AG
Journal of Oral and Maxillofacial Surgery | Year: 2014

Purpose The aim of this study was to test whether early loading (21 days after insertion) of implants with a hydrophilic surface is safe and reliable in a general clinical practice setting. Patients and Methods This was a prospective multicenter clinical trial conducted in 3 independent surgical practices. Patients were selected according to predefined inclusion and exclusion criteria. Implants were placed in posterior regions into healed alveoli and native bone using a 1-stage (unsubmerged) surgical protocol. Loading was to be performed 21 days thereafter. Patients were followed clinically and radiographically for 1 year. Results Twenty-one patients who received 23 implants were followed for 1 year. None of the osseointegrated implants were lost. One broken provisional crown was reported during the trial period. The crestal bone remained remarkably stable (ie, approximately 1 mm below the microgap). The most coronal bone-to-implant contact stabilized at the level of the first implant thread just beneath the machined collar. Conclusion Within the limitations of this clinical study, the authors confirmed that loading of implants with a hydrophilic surface 3 weeks after placement appears to be a safe and predictable treatment option. No crestal bone loss was observed 1 year after implant placement. Therefore, it appears that crestal bone loss is dependent on the design features of the specific implant line. © 2014 American Association of Oral and Maxillofacial Surgeons.


Milleret V.,ETH Zurich | Hefti T.,ETH Zurich | Hefti T.,Thommen Medical AG | Hall H.,ETH Zurich | And 2 more authors.
Acta Biomaterialia | Year: 2012

Electrospun grafts have been widely investigated for vascular graft replacement due to their ease and compatibility with many natural and synthetic polymers. Here, the effect of the processing parameters on the scaffold's architecture and subsequent reactions of partially heparinized blood triggered by contacting these topographies were studied. Degrapol® (DP) and poly(lactic-co-glycolic acid) (PLGA) electrospun fibrous scaffolds were characterized with regard to fiber diameter, pore area and scaffold roughness. The study showed that electrospinning parameters greatly affect fiber diameter together with pore dimension and overall scaffold roughness. Coagulation cascade activation, early platelet adhesion and activation were analyzed after 2 h of exposure of blood to the biomaterials. While no differences were found between DP and PLGA with similar topographies, the blood reactions were observed to be dependent on the fiber diameter and scaffold roughness. Scaffolds composed of thin fibers (diameter <1 μm) triggered very low coagulation and almost no platelets adhered. On the other hand, scaffolds with a bigger fiber diameter (2-3 μm) triggered higher thrombin formation and more platelets adhered. The highest platelet adhesion and activations rates as well as coagulation cascade activation were found in blood incubated in contact with the scaffolds produced with the biggest fiber diameter (5 μm). These findings indicate that electrospun grafts with small fiber diameter (<1 μm) could perform better with reduced early thrombogenicity due to lower platelet adhesion and lower activation of platelets and coagulation cascade. © 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.


Milleret V.,ETH Zurich | Tugulu S.,Thommen Medical AG | Schlottig F.,Thommen Medical AG | Hall H.,ETH Zurich
European Cells and Materials | Year: 2011

Titanium implants are most commonly used for bone augmentation and replacement due to their favorable osseointegration properties. Here, hyperhydrophilic sand-blasted and acid-etched (SBA) titanium surfaces were produced by alkali treatment and their responses to partially heparinized whole human blood were analyzed. Blood clot formation, platelet activation and activation of the complement system was analyzed revealing that exposure time between blood and the material surface is crucial as increasing exposure time results in higher amount of activated platelets, more blood clots formed and stronger complement activation. In contrast, the number of macrophages/monocytes found on alkali-treated surfaces was significantly reduced as compared to untreated SBA Ti surfaces. Interestingly, when comparing untreated to modified SBA Ti surfaces very different blood clots formed on their surfaces. On untreated Ti surfaces blood clots remain thin (below 15 mm), patchy and non-structured lacking large fibrin fiber networks whereas blood clots on differentiated surfaces assemble in an organized and layered architecture of more than 30 mm thickness. Close to the material surface most nucleated cells adhere, above large amounts of non-nucleated platelets remain entrapped within a dense fibrin fiber network providing a continuous cover of the entire surface. These findings might indicate that, combined with findings of previous in vivo studies demonstrating that alkali-treated SBA Ti surfaces perform better in terms of osseointegration, a continuous and structured layer of blood components on the blood-facing surface supports later tissue integration of an endosseous implant.


PubMed | Swiss Center for Regenerative Medicine, University of Zürich, ETH Zurich and Thommen Medical AG
Type: | Journal: Scientific reports | Year: 2016

Low correlations of cell culture data with clinical outcomes pose major medical challenges with costly consequences. While the majority of biomaterials are tested using in vitro cell monocultures, the importance of synergistic interactions between different cell types on paracrine signalling has recently been highlighted. In this proof-of-concept study, we asked whether the first contact of surfaces with whole human blood could steer the tissue healing response. This hypothesis was tested using alkali-treatment of rough titanium (Ti) surfaces since they have clinically been shown to improve early implant integration and stability, yet blood-free in vitro cell cultures poorly correlated with in vivo tissue healing. We show that alkali-treatment, compared to native Ti surfaces, increased blood clot thickness, including platelet adhesion. Strikingly, blood clots with entrapped blood cells in synergistic interactions with fibroblasts, but not fibroblasts alone, upregulated the secretion of major factors associated with fast healing. This includes matrix metalloproteinases (MMPs) to break down extracellular matrix and the growth factor VEGF, known for its angiogenic potential. Consequently, in vitro test platforms, which consider whole blood-implant interactions, might be superior in predicting wound healing in response to biomaterial properties.


Grant
Agency: European Commission | Branch: FP7 | Program: BSG-SME | Phase: SME-2012-1 | Award Amount: 1.48M | Year: 2012

Peri-implant disease is a true threat in todays advancement of implant reliability and performance. The diagnostic approach followed in this grant is for early recognition of peri-implant diseases. Our System is sensing Matrix metalloproteinase 8 (MMP-8) regulation indicative for connective tissue degradation as present at the borderline of gingivitis/mucositis and periodontitis/peri-implantitis. We detect risk factors at the earliest possible moment directly facing todays challenge in dental implantation successes: The delayed recognition of peri-implant complications which are typically recognized only once clinical signs appear - a stage at which the disease course may be irreversible and lasting complications may prevail at the site of the implant zone. Consequently, the proposed system is designed to allow on-demand, self monitoring with the subject / patient providing surveillance of the peri-implant disease status. It is this patient-supported surveillance which upon report by the patient will allow the dentist to diagnose at an early disease state, potentially allowing relatively easy treatment modalities and as compared to the harsher approaches typically required at later stages. The monitoring device for the proposed system is the human tongue. The diagnostic approach is deploying a protease / MMP-8 sensitive peptide sequence, coupled to a flavoring substance. This platform is (i) either coupled to the superior (cranial) aspect of a dental implant or (ii) to spheres, which in return are formulated into a chewing gum. In response to elevated MMP-8 levels as an early signs of peri-implant disease (MMP-8 is highly predictive for peri-implant diseases) the flavoring substance is released and sensed by the patients gustatory system. It is this self-monitoring which we believe renders the system truly disruptive and radically opens novel opportunities for early diagnosis and treatment modalities of peri-implant disease.


Tugulu S.,Thommen Medical AG | Lowe K.,TU Dresden | Scharnweber D.,TU Dresden | Schlottig F.,Thommen Medical AG
Journal of Materials Science: Materials in Medicine | Year: 2010

A new strategy to render intrinsically hydrophobic microrough titanium implant surfaces superhydrophilic is reported, which is based on a rapid treatment with diluted aqueous sodium hydroxide solutions. The physicochemical characterization and protein interaction of the resulting superhydrophilic implant surfaces are presented. The superhydrophilicity of alkali treated microrough titanium substrates was mainly attributed to deprotonation and ion exchange processes in combination with a strong enhancement of wettability due to the roughness of the used substrates. Albeit these minor and mostly reversible chemical changes qualitative and quantitative differences between the protein adsorption on untreated and alkali treated microrough titanium substrates were detected. These differences in protein adsorption might account for the enhanced osseointegrative potential of superhydrophilic alkali treated microrough implant surfaces. The presented alkali treatment protocol represents a new clinically applicable route to superhydrophilic microrough titanium substrates by rendering the implant surface superhydrophilic "in situ of implantation". © 2010 Springer Science+Business Media, LLC.


Patent
Thommen Medical Ag | Date: 2011-01-13

A metal implant, in particular a dental implant, with a hydrophilic surface for at least partial insertion into a bone, and a method for the production of said implant are described. A particularly advantageous hydrophilic surface for improved osteointegration properties is made available if it is briefly treated, at least in some areas, in a weakly alkaline solution. These excellent osteointegration properties can be achieved in a method in which, optionally after a preceding mechanical surface modification by material removal and/or chemical surface modification, at least the areas exposed of this surface exposed to bone and/or soft tissue are chemically modified in an alkaline solution.


Patent
Thommen Medical Ag | Date: 2014-12-31

A package (1) for a dental implant (2) comprising a housing (5) with a compartment (51), closable liquid-tight by cover (4) and for receiving a first section (2) of the implant (2), and an area (19) for a second section (3) of the implant (2). The area is separated rated from the compartment (51) by housing wall (8). A passage (35) in wall (8) connects the compartment (51) and area (19). The housing wall (8) comprises a removal slot (9, 36) for removal of the implant when the cover (4) is open without separating the sections (2, 3). The package (1) has a fluid cartridge (12) and an associated release element (18) and the fluid cartridge (12) can be opened by way of the release element (18) when the cover (4) is closed such that fluid located in the fluid cartridge (12) can flow out into the compartment (51).


The document proposes a diagnostic chewing gum for identifying the presence of inflammatory tissues in the mouth, in particular in or adjacent to the mandible, the maxilla, an implant or the teeth of a user, comprising a base material or particles (3) embedded and/or attached to said base material; an element (1, 5-7), like e.g. a releasable flavor molecule, attached to said base material and/or said particles, for the generation of a change in the chewing gum directly detectable by the user; wherein the element (1, 5-7) generates the change upon direct or indirect contact with a marker (4), e.g. a proteolytic enzyme, which is released by inflammatory tissue in response to bacterial mediators.


Patent
Thommen Medical Ag | Date: 2010-11-11

A metal implant, in particular a dental implant, with a hydrophilic surface for at least partial insertion into a bone, and a method for the production of said implant are described. A particularly advantageous hydrophilic surface for improved osteointegration properties is made available if it is briefly treated, at least in some areas, in a weakly alkaline solution. These excellent osteointegration properties can be achieved in a method in which, optionally after a preceding mechanical surface modification by material removal and/or chemical surface modification, at least the areas exposed of this surface exposed to bone and/or soft tissue are chemically modified in an alkaline solution.

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