River Road, ME, United States
River Road, ME, United States

Thomas College is a business and liberal arts College, located in Waterville, Maine, Thomas specializes in business, education, and technology. Thomas offers undergraduate and graduate degrees and is accredited by the New England Association of Schools and Colleges Wikipedia.

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Staudacher H.M.,King's College London | Irving P.M.,Thomas College | Lomer M.C.E.,Thomas College | Whelan K.,King's College London
Nature Reviews Gastroenterology and Hepatology | Year: 2014

IBS is a debilitating condition that markedly affects quality of life. The chronic nature, high prevalence and associated comorbidities contribute to the considerable economic burden of IBS. The pathophysiology of IBS is not completely understood and evidence to guide management is variable. Interest in dietary intervention continues to grow rapidly. Ileostomy and MRI studies have demonstrated that some fermentable carbohydrates increase ileal luminal water content and breath hydrogen testing studies have demonstrated that some carbohydrates also increase colonic hydrogen production. The effects of fermentable carbohydrates on gastrointestinal symptoms have also been well described in blinded, controlled trials. Dietary restriction of fermentable carbohydrates (popularly termed the 'low FODMAP diet') has received considerable attention. An emerging body of research now demonstrates the efficacy of fermentable carbohydrate restriction in IBS; however, limitations still exist with this approach owing to a limited number of randomized trials, in part due to the fundamental difficulty of placebo control in dietary trials. Evidence also indicates that the diet can influence the gut microbiota and nutrient intake. Fermentable carbohydrate restriction in people with IBS is promising, but the effects on gastrointestinal health require further investigation. © 2014 Macmillan Publishers Limited.

Greenbaum L.E.,Thomas College | Wells R.G.,University of Pennsylvania
International Journal of Biochemistry and Cell Biology | Year: 2011

In response to liver injury or loss of liver mass, proliferation of mature liver cells is the first-line defense to restore liver homeostasis. In the setting of chronic liver disease, however, the ability of hepatocytes and cholangiocytes to proliferate is blocked and small bipotential progenitor cells are activated. Recent studies have established the role of these facultative progenitor cells in injury repair and fibrosis in patients with chronic liver disease and in experimental models. Several signaling pathways linking progenitor cell activation and fibrosis have been identified, and there is increasing evidence that cross-talk (both physical and via soluble factors) between progenitor cells and myofibroblasts is essential for both fibrosis and parenchymal regeneration. Even more exciting are new data examining the cellular components of the progenitor cell niche, demonstrating that both resident liver cells and circulating cells from the bone marrow can function as stem cells, suggesting that there is a surprising degree of phenotypic plasticity such that progenitor cells can contribute to the myofibroblast population and vice versa. We highlight here recent findings from the literature demonstrating the cellular and functional complexity of the progenitor cell niche, and emphasize some of the important questions that remain to drive future research. © 2010 Elsevier Ltd. All rights reserved.

EVANSVILLE, Ind., Nov. 01, 2016 (GLOBE NEWSWIRE) -- Dick Dubé, Old National’s Chief Audit Executive and Ethics Officer, and a member of the company’s Executive Leadership Group, has announced that he will retire May 5, 2017.  Dubé joined Old National as General Auditor in 1997, was promoted to Audit and Risk Manager in 1999, and assumed his current role of Chief Audit Executive in 2001. In 2008, Old National Chairman and CEO Bob Jones tasked Dubé with the additional responsibility of becoming Old National’s first Ethics Officer. Under Dubé’s guidance, Old National has been named one of the World’s Most Ethical Companies™ for five straight years by the Ethisphere Institute. Old National’s corporate culture and adherence to ethics have also been certified by Ethisphere for the past seven years (Ethics Inside Certification™). “As a servant leader, Dick is well known for his integrity, compassion and team-first approach,” said Old National Chairman and CEO Bob Jones. “I know I speak for countless others in wishing him and his family all the best as they begin this richly earned new chapter. He will be greatly missed.” Andy Goebel, Old National Bancorp Board member and Chairman of the Board’s Audit Committee, said he has been extremely fortunate to have worked closely with Dubé for a number of years. “In addition to being a consummate professional who is highly regarded by his peers, Dick has been an outstanding leader of the associates in the internal audit department as well as a valued member of Old National’s executive management team,” said Goebel. Replacing Dubé as Chief Audit Executive and Ethics Officer, and joining Old National’s Executive Leadership Group, is Joan Kissel. Kissel will transition from her current role as Old National’s Corporate Controller to assume this new role. A Certified Public Accountant and Chartered Global Management Accountant, Kissel joined Old National in 2005 as Assistant Controller and was promoted to Corporate Controller a year later. She is a graduate of Indiana University’s Kelley School of Business where she earned a bachelor’s degree in Accounting. She serves on the Board of Trustees for the Vanderburgh Community Foundation. “Joan has been an integral part of our management team for the past several years, and I have the utmost confidence in her ability to continue the strong success that Old National has experienced under Dick’s leadership,” said Jones. “Our Board and our company have benefited immensely from Joan’s high standards, knowledge and dedication as she guided the company’s accounting and financial reporting over the past 10 years,” added Goebel. “We look forward to continuing to work with Joan in her expanded role as Old National’s Chief Audit Executive.” Dubé’s retirement closes the book on more than 40 years of bank internal audit experience at various financial institutions in Maine, Wisconsin, Ohio, Oklahoma and Louisiana. He earned a bachelor’s degree in accounting from the Thomas College in Waterville, Maine. He is also a graduate of the Kellogg School of Management’s Executive Development Program at Northwestern University. Dubé holds several professional certifications including CBA (Certified Bank Auditor); CFSA (Certified Financial Services Auditor); CRP (Certified Risk Professional) and CFIRS (Certified Fiduciary and Investment Risk Specialist). He is also a member of the Institute of Internal Auditors, Fiduciary and Investment Risk Management Association, Financial Services Auditor Group and Ethics & Compliance Officers Association. Dubé serves as the Board Chair for the Dunigan Family YMCA, and is an Executive Committee member and a member of the Metro Board of the YMCA of Southwestern Indiana. Old National Bancorp (NASDAQ:ONB), the holding company of Old National Bank, is the largest financial services holding company headquartered in Indiana. With $14.7 billion in assets, it ranks among the top 100 banking companies in the U.S.  Since its founding in Evansville in 1834, Old National Bank has focused on community banking by building long-term, highly valued partnerships with clients. Today, Old National’s footprint includes Indiana, Kentucky, Michigan and Wisconsin. In addition to providing extensive services in retail and commercial banking, Old National offers comprehensive wealth management, investments and brokerage services. For more information and financial data, please visit Investor Relations at oldnational.com.

Carini M.T.,Western Kentucky University | Ryle W.T.,Thomas College
Astrophysical Journal | Year: 2012

The Seyfert 1 galaxy II ZW 229.015 has been observed with the Kepler spacecraft since quarter 4 of Kepler science operations. The results of the quarters 4-7 (1 year) Kepler observations are presented in this paper. We find the source to be highly variable on multiple timescales, with discrete variations occurring on timescales as short as tens of hours with amplitudes as small as 0.5%. Such small amplitude, rapid variability has never before been detected in active galactic nuclei. The presence of a strong galaxy component dilutes the variability determined from the photometric aperture used in the standard Kepler PDC analysis. Using the tools provided by the Kepler Guest Observer Office and simultaneous V-band photometry found in the literature, we determine an optimal customized aperture for photometry of this source with Kepler. The results of a PSRESP analysis reveal tentative evidence of a characteristic variability timescale in the power spectrum. Using this timescale, we estimate the mass of the central supermassive black hole and this estimate is consistent with the virial mass estimate from reverberation mapping studies. © 2012. The American Astronomical Society. All rights reserved.

John M.V.,Thomas College
Annals of Physics | Year: 2010

It is shown that a normalisable probability density can be defined for the entire complex plane in the modified de Broglie-Bohm quantum mechanics, which gives complex quantum trajectories. This work is in continuation of a previous one that defined a conserved probability for most of the regions in the complex space in terms of a trajectory integral, indicating a dynamical origin of quantum probability. There it was also shown that the quantum trajectories obtained are the same characteristic curves that propagate information about the conserved probability density. Though the probability density we now adopt for those regions left out in the previous work is not conserved locally, the net source of probability for such regions is seen to be zero in the example considered, allowing to make the total probability conserved. The new combined probability density agrees with the Born's probability everywhere on the real line, as required. A major fall out of the present scheme is that it explains why in the classical limit the imaginary parts of trajectories are not observed even indirectly and particles are confined close to the real line. © 2010 Elsevier Inc.

Berghella V.,Thomas College
Cochrane database of systematic reviews (Online) | Year: 2013

Measurement of cervical length (CL) by transvaginal ultrasound (TVU) is predictive of preterm birth (PTB). It is unclear if this screening test is effective for prevention of PTB. To assess the effectiveness of antenatal management based on transvaginal ultrasound of cervical length (TVU CL) screening for preventing PTB. We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 August 2012), reviewed the reference lists of all articles and contacted experts in the field for additional and ongoing trials. Published and unpublished randomized controlled trials including pregnant women between the gestational ages of 14 to 32 weeks screened with TVU CL for risk of PTB. This review focuses exclusively on studies based on knowledge versus no knowledge of TVU CL results. All potential studies identified from the search were independently assessed for inclusion by three review authors. We also analyzed studies for quality measures and extracted data. Of the 13 trials identified, five were eligible for inclusion (n = 507). Three included singleton gestations with preterm labor (PTL); one included singleton gestations with preterm premature rupture of membranes (PPROM); and one included twin gestations with or without PTL.In the three trials of singleton gestations with PTL, 290 women were randomized; 147 to knowledge and 143 to no knowledge of TVU CL. Knowledge of TVU CL results was associated with a non-significant decrease in PTB at less than 37 weeks (22.3% versus 34.7%, respectively; average risk ratio 0.59, 95% confidence interval (CI) 0.26 to 1.32; two trials, 242 women) and at less than 34 weeks (6.9% verus 12.6%; RR 0.55, 95% CI 0.25 to 1.20; three trials, 256 women). Delivery occurred at a later gestational age in the knowledge versus no knowledge groups (mean difference (MD) 0.64 weeks, 95% CI 0.03 to 1.25; three trials, 290 women). For all other outcomes for which there were available data (PTB at less than 34 or 28 weeks; birthweight less than 2500 grams; perinatal death; maternal hospitalization; tocolysis; and steroids for fetal lung maturity), there was no evidence of a difference between groups.The trial of singleton gestations with PPROM (n = 92) evaluated as its primary outcome safety of TVU CL in this population, and not its effect on management. There was no evidence of a difference in incidence of maternal and neonatal infections between the TVU CL and no TVU CL groups.In the trial of twin gestations with or without PTL (n = 125), there was no evidence of a difference in PTB at less than 36, 34, or 30 weeks, gestational age at delivery, and other perinatal and maternal outcomes between the TVU CL and the no TVU CL groups. Life-table analysis revealed significantly less PTB at less than 35 weeks in the TVU CL group compared with the no TVU CL group (P = 0.02). Currently, there is insufficient evidence to recommend routine screening of asymptomatic or symptomatic pregnant women with TVU CL. Since there is a non-significant association between knowledge of TVU CL results and a lower incidence of PTB at less than 37 weeks in symptomatic women, we encourage further research. Future studies should look at specific populations separately (e.g., singleton versus twins; symptoms of PTL or no such symptoms), report on all pertinent maternal and perinatal outcomes, and include cost-effectiveness analyses. Most importantly, future studies should include a clear protocol for management of women based on TVU CL results, so that it can be easily evaluated and replicated.

Stevens R.G.,University of Connecticut Health Center | Brainard G.C.,Thomas College | Blask D.E.,Tulane University | Lockley S.W.,Harvard University | Motta M.E.,Tufts Medical School
CA Cancer Journal for Clinicians | Year: 2014

Breast cancer is the leading cause of cancer death among women worldwide, and there is only a limited explanation of why. Risk is highest in the most industrialized countries but also is rising rapidly in the developing world. Known risk factors account for only a portion of the incidence in the high-risk populations, and there has been considerable speculation and many false leads on other possibly major determinants of risk, such as dietary fat. A hallmark of industrialization is the increasing use of electricity to light the night, both within the home and without. It has only recently become clear that this evolutionarily new and, thereby, unnatural exposure can disrupt human circadian rhythmicity, of which three salient features are melatonin production, sleep, and the circadian clock. A convergence of research in cells, rodents, and humans suggests that the health consequences of circadian disruption may be substantial. An innovative experimental model has shown that light at night markedly increases the growth of human breast cancer xenografts in rats. In humans, the theory that light exposure at night increases breast cancer risk leads to specific predictions that are being tested epidemiologically: evidence has accumulated on risk in shift workers, risk in blind women, and the impact of sleep duration on risk. If electric light at night does explain a portion of the breast cancer burden, then there are practical interventions that can be implemented, including more selective use of light and the adoption of recent advances in lighting technology and application. CA Cancer J Clin 2014;64:207-218. © 2013 American Cancer Society. © 2013 American Cancer Society, Inc.

Mackeen A.D.,Thomas College
Cochrane database of systematic reviews (Online) | Year: 2012

Caesarean section is a common operation with no agreed upon standard regarding certain operative techniques or materials to use. With regard to skin closure, the skin incision can be re-approximated by a subcuticular suture immediately below the skin layer, by an interrupted suture, or by staples. A great variety of materials and techniques are used for skin closure after caesarean section and there is a need to identify which provide the best outcomes for women. To compare the effects of skin closure techniques and materials on maternal and operative outcomes after caesarean section. We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (10 January 2012). All randomized trials comparing different skin closure materials in caesareans were selected. Two review authors independently abstracted the data. We identified 19 trials and included 11, but only eight trials contributed data. Three trials were not randomized controlled trials; two were ongoing; one study was terminated and the results were not available for review; one is awaiting classification; and one did not compare skin closure materials, but rather suture to suture and drain placement. The two methods of skin closure for caesarean that have been most often compared are non-absorbable staples and absorbable subcutaneous sutures. Compared with absorbable subcutaneous sutures, non-absorbable staples are associated with similar incidences of wound infection. Other important secondary outcomes, such as wound complications, were also similar between the groups in women with Pfannenstiel incisions. However, it is important to note, that for both of these outcomes (wound infection and wound complication), staples may have a differential effect depending on the type of skin incision, i.e., Pfannenstiel or vertical. Compared with absorbable subcutaneous sutures, non-absorbable staples are associated with an increased risk of skin separation, and therefore, reclosure. However, skin separation was variably defined across trials, and most staples were removed before four days postpartum. There is currently no conclusive evidence about how the skin should be closed after caesarean section. Staples are associated with similar outcomes in terms of wound infection, pain and cosmesis compared with sutures, and these two are the most commonly studied methods for skin closure after caesarean section. If staples are removed on day three, there is an increased incidence of skin separation and the need for reclosure compared with absorbable sutures.

Weinstein A.G.,Thomas College
Journal of Allergy and Clinical Immunology: In Practice | Year: 2013

Background: Nonadherence to asthma treatment has been related to increased hospital and emergency care, morbidity, and unnecessary costs. Improving patient adherence is a key component to achieving optimal outcomes. Objective: Review barriers, interventions, and communication skills shown to be effective in promoting asthma adherence. Methods: Asthma adherence literature was reviewed. Results: Sequential management principles to achieve adherence include the following: (1) measuring adherence, (2) identifying barriers that result in nonadherence, (3) using specific strategies to overcome barriers; and (4) using communication skills to enhance the delivery of selected strategies. Conclusion: Careful attention to adherence management principles may increase adherence, enhance outcomes, and reduce unnecessary morbidity and cost. The case described applies these principles and gives the reader a framework to review. © 2013 American Academy of Allergy, Asthma & Immunology.

Agency: NSF | Branch: Standard Grant | Program: | Phase: ADVANCED TECH EDUCATION PROG | Award Amount: 199.04K | Year: 2016

To be successful in the economy of today, industry requires multi-skilled technicians who possess both technical and non-technical skills. To address this need, this project at Thomas Nelson Community College (TNCC) in Virginia is designed to develop an innovative model to augment technician education with competencies that blend essential technical and non-technical skills and expand awareness of 21st century manufacturing. The model is in alignment with an advanced manufacturing competency model available through the U.S. Department of Labor that documents the skills and competencies required for workplace success in advanced manufacturing industries. The blended model for technician education will be utilized in the new Associate of Applied Science degree program in Advanced Integrated Manufacturing Technology (AIMT) at the college that was developed with industry partners to address an industry defined need for multi-skilled technicians in advanced manufacturing as well as in other technician education programs at the college and will result in students entering the workforce with 21st century skills. Expanding awareness of 21st century manufacturing will ensure that new talent is attracted to manufacturing to address the critical need for multi-skilled technicians.

Through collaboration with regional manufacturers and community partners, the goal of the project will be achieved through: 1) development of courses and modules that integrate non-technical competencies with technical content and 2) expansion of awareness of technical advancements and career opportunities in manufacturing through outreach activities to groups of potential students who may not have considered manufacturing as a career including high schools and veterans groups. With support of a planning grant provided in 2013 by the Virginia General Assembly, and several other regional studies conducted between 2011 and 2013, the college documented employer hiring needs for advanced manufacturing within the region. The AIMT program contains essential elements modeled after the ATE and NASA SpaceTEC program (DUE 1303935) that organizes students into cohorts that enter and progress through the program together and integrates academic instruction with rotating co-op/internship at multiple job sites under the supervision of subject matter experts (SMEs). An extensive evaluation is planned to determine the impact on worker performance of incorporating instruction on specific non-technical workplace competencies such as team building and diversity into the technician education program. The knowledge and application of non-technical competencies of students will be evaluated by comparing the non-technical competency and job performance of students in a cohort that did not receive the non-technical instruction with those of students in cohorts that receive that instruction. Activities can be replicated and integrated into advanced manufacturing degree programs and other science, technology, engineering, and mathematics (STEM) technician education programs offered at community colleges throughout the country. Materials highlighting the technical advancements of 21st century manufacturing and career opportunities will be developed and shared widely with secondary and post-secondary institutions and other stakeholders through the college website and social media outlets. The new model of technician education and promotional materials will be showcased through ATE Central, TeachingTechnicians.org, presentations at professional meetings, and web based communications.

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