Third Peoples Hospital of Zhengzhou
Third Peoples Hospital of Zhengzhou
Cao Y.,Third Peoples Hospital of Zhengzhou |
Zhao D.,Third Peoples Hospital of Zhengzhou |
Li P.,Women and Infants Hospital of Zhengzhou |
Wang L.,Third Peoples Hospital of Zhengzhou |
And 4 more authors.
Cellular Physiology and Biochemistry | Year: 2017
Aim: The contribution of the inflammatory mediator interleukin-17 (IL-17) in nonsmall cell lung cancer (NSCLC) malignancy has been reported in the literature. MicroRNA-181a-5p (miR-181a-5p) acts as a tumor suppressor which can regulate target gene at the posttranscriptional level. Our study aimed to investigate the interaction between IL-17 and miR-181a-5p in NSCLC. Methods: 35 patients with NSCLC and 24 COPD controls were selected and examined in our study. In vitro, H226 and H460 cell lines were exposed to different doses (20, 40, 60, and 80 ng/mL) of IL-17 to examine the effect of IL-17 on miR-181a-5p and vascular cell adhesion molecule 1 (VCAM-1) expression. MiR-181 mimic and miR-181a-5p inhibitor were transfected to explore the regulation of VCAM-1 as well as tumor cell proliferation and migration. Results: MiR-181a-5p expression was downregulated, and IL-17 and VCAM-1 expression was upregulated in NSCLC tissues. Furthermore, IL-17 decreased miR-181a-5p expression but increased VCAM-1 expression in H226 and H460 cells. MiR-181 regulated VCAM-1 expression through binding to 3'-UTR sequence. MiR-181 attenuated tumor cell proliferation and migration. IL-17 modulated miR-181a-5p expression through activating NF-κB but not Stat3. Conclusion: Taken together, our data show the regulation of VCAM-1 expression by miR-181a-5p under IL-17 exposure, predicting a potential way for counteracting cancer metastasis. © 2017 The Author(s). Published by S. Karger AG, Basel.
Kong T.-D.,Third Peoples Hospital of Zhengzhou |
Zhu M.,Third Peoples Hospital of Zhengzhou |
Gao W.-Y.,Third Peoples Hospital of Zhengzhou |
Yao L.-G.,Third Peoples Hospital of Zhengzhou |
And 2 more authors.
Chinese Journal of Cancer Prevention and Treatment | Year: 2014
OBJECTIVE: To observe the effect on quality of life (QOL) in patients treated with S-1 plus oxiliplatin and FOLFOX4.METHODS: Sixty patients were ramdomly divided into SOX group and FOLFOX4 group, SOX group was given S-1 plus oxalipitin, oxaliplatin was administered intravenously on d1 with 130 mg/m2, S-1 was administered orally from d1 to d14 at the following doses on the basis of body surface area (BSA): BSA<1.25 m2, 80 mg daily; 1.25 m2≤BSA<1.5 m2, 100 mg daily; 1.5 m2≤BSA<1.8 m2, 120 mg, daily; BSA>1.8 m2, 140 mg, daily; every 3 weeks as a cycle. Efficacy was evaluated at least after 2 cycles. In FOLFOX4 group oxaliplatin was administered intravenously on d1 with 80 mg/m2, leucovorin was given intravenously on d1 and d2 with 200 mg/m2, 5-FU was intravenous injection on d1 and d2 with 400 mg/m2, and was administered intravenously 22 hours on d1 and d2 with 600 mg/m2. The assessment methods of QOF was QLQ-CR68 questionnaire.RESULTS: Patients' background and characteristics were similar, all of the 60 patients could be evaluated. The overall response rate in SOX was 46.7% and in FOLFOX4 it was 36.7%, χ2=0.617, P=0.432. In questionnaire questions such as fatigue, nausea and vomiting, gastrointestinal symptoms, pain, appetite loss, urination, defecation and weight loss were inquired, comparing the improvement of life quality between the two groups, SOX was improved more obviously in relieving of nausea and vomiting, chemotherapy toxicity, gastrointestinal symptoms, defecation, and weight loss, the P values were all less than 0.05.In total heath score, SOX(70.03±16.15) and FOLFOX4(60.46±15.31) groups showed significantly better results than before chemotherapy. Furthermore, the SOX team was improved deeply before and after chemotherapy between the two groups, t=2.076 9, P=0.0423.CONCLUSIONS: The present results suggest that questionnaires are useful for assessing patients' QOL with advanced CRC treated chemotherapy. Combination chemotherapy with oral fluoropyrimidine S-1 plus oxiliplatin could improve QOL better than Folfox4, we can increase the sample size in the further research.
Shi T.-W.,Peoples Hospital of Zhengzhou |
Ren X.-K.,Third Peoples Hospital of Zhengzhou |
Yu H.-X.,Sun Yat Sen University |
Tang Y.-B.,Sun Yat Sen University
Dermatology | Year: 2012
Background: Ketoconazole is a typical treatment available for pityriasis versicolor; tretinoin cream is effective, too. Adapalene gel is a tretinoin derivative and has a lower incidence of irritation compared with other topical retinoid products. However, there are no reports on adapalene gel for the treatment of pityriasis versicolor. Objective: To study the effect of adapalene gel comparing the treatment with adapalene gel and 2% ketoconazole cream in pityriasis versicolor. Methods: Eighty patients suffering from pityriasis versicolor were randomly divided into two groups; one group were treated with 2% ketoconazole cream topically twice daily for 2 weeks, adapalene gel was used for the other group in a similar fashion. Results: There were no significant differences in efficacy between the two groups. No major side effects were noted in any of the groups either. Conclusion: Adapalene was the favorable option in the treatment of pityriasis versicolor. The probable therapeutic mechanism of adapalene is also discussed. Copyright © 2012 S. Karger AG, Basel.
Han L.-J.,Third Peoples Hospital of Zhengzhou |
Ma H.-X.,Third Peoples Hospital of Zhengzhou |
Dong X.-J.,Third Peoples Hospital of Zhengzhou |
Wang X.-J.,Third Peoples Hospital of Zhengzhou |
And 3 more authors.
Journal of Leukemia and Lymphoma | Year: 2012
Objective: To analyse the etiology, clinical characteristics and risk factors of central nervous system (CNS) complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods: The clinical features of CNS complications in patients who underwent allo-HSCT were observed, and analysis its causes and risk factors. Results: 8 cases of CNS complications occured in 69 patients within 6 months after allo-HSCT and the incidence was 11.6 %, the occurrence rate of CNS complications was 21.4 % (6/28) in HLA mismatched group, higher than HLA matched group [4.9 % (2/41)] (P < 0.05). Analogously, the incidence was 44.4 % (4/60) in patients with graft-versus-host disease (GVHD) (>grade 2), which was significantly higher than patients with 2 or below grade 2 GVHD [6.7 % (4/9)] (P < 0.01). But there was no significant difference in the incidence of CNS complications between ≤ 14 years old and >14 years old, with or without ATG, different stages of diseases, whether pretreatment with maryland respectively (P > 0.05), either. Epilepsy and intracranial infection were the most common CNS complications in allo-HSCT, followed by intracranial hemorrhage. Conclusion: HLA mismatched and above grade 2 GVHD are the risk factors of CNS complications in allo-HSCT. Epilepsy,intracranial infection and bleeding are common CNS complications in allo-HSCT.