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Luo C.-Q.,Huazhong University of Science and Technology | Zhang Y.-A.,The Third Peoples Hospital of Yunnan Province | Li Z.-Q.,Huazhong University of Science and Technology | Wang Y.-M.,Huazhong University of Science and Technology
Journal of Huazhong University of Science and Technology - Medical Science | Year: 2015

The correlations between the clinicopathological features and the long-term outcomes of renal amyloidosis (RA) were analyzed with a view to develop strategies for improving diagnosis and prognosis of RA. We retrospectively reviewed the clinicopathological characteristics of 47 patients diagnosed with RA between 2004 and 2014 at the Wuhan Union Hospital. The data on the renal histology, clinical manifestations, and prognosis of RA patients were retrieved from the hospital records and characteristic patterns were identified. The histological changes in the kidneys were correlated with the clinical manifestations of RA. Additionally, most RA patients in this study had decreased serum levels of κ light chain and increased urine levels of κ and λ light chains as well as presence of M-protein in the urine and serum. Patients with early RA showed no specific pathognomonic symptoms. Bleeding associated with diagnostic renal biopsy was rare. We recommend that the routine work-up of patients aged over 40 years and presenting with non-diabetic nephropathy includes the non-invasive tests for the measurement of serum and urine levels of κ and λ light chains as well as protein electrophoresis tests for the presence of urinary and serum M-protein. Additionally, such patients should undergo renal biopsy screening with Cong-red staining to ensure early diagnosis of RA and improve their survival, since the risk of hemorrhage related to renal biopsy screening is low at early stages of RA. © 2015, Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg. Source


He Y.,Harbin Medical University | Han L.,Harbin Medical University | Li W.,The Third Peoples Hospital of Yunnan Province | Shu X.,University of Houston | And 4 more authors.
Gene | Year: 2012

The calcium-sensing receptor (CaSR) is involved in maintaining calcium homeostasis via the regulation of parathyroid hormone (PTH) secretion. The associations between serum calcium concentrations, parathyroid hormone (PTH) level and CaSR polymorphism A986S have been studied, but results are inconsistent. Therefore, we performed a meta-analysis to clarify the role of this polymorphism on this topic. Weighted mean difference (WMD) and 95% confidence interval (CI) were calculated with random-effects model or fixed-effects model based on the heterogeneity analysis. Overall 2820, 1135 and 3149 healthy individuals were included for total calcium concentration, ionized calcium concentration and PTH level meta-analyses, respectively. Most of the individuals in this meta-analysis were healthy women. Healthy individuals with the AS. +. SS genotype had significantly higher total and ionized calcium concentrations than those with the AA genotype. However, there was no statistical significance concerning serum PTH level. The pooled WMD for total calcium concentration was 0.028 (95% CI: 0.012-0.045, P = 0.001); for ionized calcium concentration was 0.016 (95% CI: 0.013-0.020, P < 0.0001); and for PTH level was - 0.027 (95% CI: -0.360-0.306, P = 0.874). In conclusion, our meta-analysis indicates that the CaSR A986S polymorphism might be associated with total and ionized calcium concentrations in healthy individuals. © 2011 Elsevier B.V. Source


Li B.,Kunming Medical University | Ruan Y.,Kunming Medical University | Ma L.,Kunming Medical University | Hua H.,Kunming Medical University | And 6 more authors.
Frontiers of Medicine | Year: 2015

Tin miners in Gejiu, Yunnan Province, China are at high risk of developing lung cancer with significant occupational characteristics. Tissue samples from these miners presented pathological characteristics, such as fibroplasia in carcinomas, peri-cancerous tissue in lung cancers, and hyperplasia and dysplasia of epithelial cells in peri-cancerous tissue. Carcinomas induced by Yunnan tin mine dust in the animal experiment underwent inflammation, fibroplasia, hyperplasia, dysplasia, and carcinogenesis of epithelial cells. A correlated and synergistic relationship was observed between bronchial epithelial cell transformation and fibroblast activation in vitro induced by mine dust. Fibroblast hyperplasia and activation are important factors that promote the transformation and carcinogenesis of epithelial cells. Our findings suggested that pulmonary fibrosis may increase the risk and promote the occurrence of lung cancer, which can lead to lung fiber hyperplasia. © 2015, Higher Education Press and Springer-Verlag Berlin Heidelberg. Source


Fu Y.-Y.,Nanjing Medical University | Shen Q.,The Third Peoples Hospital of Yunnan Province | Ji C.-M.,Nanjing Medical University | Huang W.,Nanjing Medical University | And 5 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2016

Cytochrome 2E1, has been reported to participate in the pathogenic process of gastrointestinal (GI) cancers. Previous studies showed that the results are conflicting. To clarify the association between cytochrome CYP2E1 RsaI polymorphism and risk of gastrointestinal cancers, we conducted this meta-analysis of 35 studies with 8267 cases and 11001 controls. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association. We found that CYP2E1 RsaI polymorphism significantly decreased the risk of GI cancers in heterozygous model (OR = 0.80, 95% CI: 0.66-0.97, Pheterogenecity = 0.027) and dominant model (OR = 0.77, 95% CI: 0.64-0.94, Pheterogenecity = 0.01). In subgroup analysis, CYP2E1 Rsa I polymorphism reduced the risk of esophageal cancer (EC) (allele model: OR = 0.64, 95% CI: 0.49-0.83, Pheterogenecity = 0.001; homozygous model: OR = 0.55, 95% CI: 0.42-0.72, Pheterogenecity < 0.01; heterozygous model: OR = 0.54, 95% CI: 0.36-0.81, Pheterogenecity = 0.003; dominant model: OR = 0.49, 95% CI: 0.33-0.72, Pheterogenecity < 0.01) and cases with GI cancers among the Asians (allele model: OR = 0.79, 95% CI: 0.68-0.91, Pheterogenecity = 0.001; heterozygous model: OR = 0.71, 95% CI: 0.60-0.86, Pheterogenecity < 0.01; dominant model: OR = 0.68, 95% CI: 0.56-0.83, Pheterogenecity < 0.01), but increased the risk of GI cancers in Caucasians (recessive model: OR = 1.53, 95% CI: 1.00-2.34, Pheterogenecity = 0.05). We also confirmed the result in the high-quality studies (heterozygous model: OR = 0.80, 95% CI: 0.65-0.98, Pheterogenecity < 0.01; dominant model: OR = 0.78, 95% CI: 0.64-0.95, Pheterogenecity < 0.01) and in the literatures written in Chinese (allele model: OR = 0.73, 95% CI: 0.54-0.98, Pheterogenecity < 0.01; heterozygous model: OR = 0.66, 95% CI: 0.48-0.92, Pheterogenecity < 0.01; dominant model: OR = 0.66, 95% CI: 0.47-0.94, Pheterogenecity < 0.01). No significant association was observed in the gastric cancer (GC) and colorectal cancer (CRC). Similar results were observed in the subgroup analysis by source of control and pHWE. In conclusion, we suggest that CYP2E1 RsaI polymorphism significantly decreased the risk of GI cancers especially in EC cancer type and in Asians population, but increased risk of GI cancers in the Caucasians. © 2016, International Journal of Clinical and Experimental Medicine. All Rights Reserved. Source


Yang J.,The Third Peoples Hospital of Yunnan Province | Zheng S.,The Third Peoples Hospital of Yunnan Province | Liu H.-Q.,The Third Peoples Hospital of Yunnan Province | Tang Y.-M.,Kunming Medical University
World Chinese Journal of Digestology | Year: 2016

AIM: To investigate the value of red blood cell distribution width (RDW) in predicting in-hospital death of patients with severe acute pancreatitis (SAP). METHODS: One hundred and fourteen SAP patients were divided into either a death or a non-death group, according to whether hospitalization death occurred. Clinical data for the two groups of patients were analyzed. The risk factors for in-hospital death were classified by binary logistic regression analysis. The value of RDW in predicting in-hospital death in patients with SAP was assessed by ROC curve analysis. RESULTS: The differences in glucose, calcium, creatinine, oxygenation index, albumin, lactate dehydrogenase, hemoglobin, red blood cells deposit, RDW, APACHEII score, and Ranson score between the death group and non-death group were statistically significant (P < 0.05). Binary classification logistic regression analysis showed that RDW, APACHEII score, Ranson score, albumin, oxygenation index, and creatinine were independent risk factors for in-hospital death (P < 0.05); the RDW regression coefficient was 0.156, and odds ratio (OR) was 1.170 (95%CI: 1.004-1.325, P = 0.008). ROC curve analysis showed that the area under the curve was 0.907 for RDW (95%CI: 0.928-0.968, P = 0.000); 0.864 for APACHEII score (95%CI: 0.812-0.915, P = 0.000); and 0.848 for oxygenation index (95%CI: 0.785-0.833, P = 0.001). CONCLUSION: RDW is an independent predictor of prognosis in patients with SAP, and has high value in predicting in-hospital death of SAP patients. © 2016 Baishideng Publishing Group Inc. Source

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