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Li J.-H.,The Third Peoples Hospital of Wuxi City | Wang H.-X.,The Third Peoples Hospital of Wuxi City
World Chinese Journal of Digestology | Year: 2015

AIM: To evaluate the effect of the usage of glutathione, Dachengqi decoction and omega-3 polyunsaturated fatty acid in acute biliary pancreatitis (ABP) patients with liver injury. METHODS: Seventy-one hospitalized patients were randomly divided into either a control group (n = 35) or a study group (n = 36). Allpatients received rout ine treatments which included oxygen uptake, fasting, gastrointestinal decompression, inhibition of panc reat i c sec ret ion and pancreatic enzyme activity, regulation of fluid, electrolytes and acid-base balance, use of antibiotics, and protecting the function of major organs. The two groups were both given parenteral nutrition with an energy of 20-25 kcal/(kg•d), a ratio of nitrogen to calorie of 1:(156.25-178.57), and a ratio of carbohydrate to fat of (50-60%):(40-50%). Fat was supported by 20% medium chain/long chain triglycerides in the control group, and by omega-3 polyunsaturated fatty acids in the study group. Meanwhile, glutathione (1200 mg/d) and Dachenqi decoction were used in the study group. Indexes of liver function, inflammatory factors and oxidative stress injury were compared for the two groups. RESULTS: There was a significant difference in alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma glutamyl transpeptidase (GGT), total bilirubin (TB), direct bilirubin (DB), triglyceride (TG), tumor necrosis factor (TNF)-α, interleukin (IL)-2, IL-6, superoxide dismutase (SOD) and methane dicarboxylic aldehyde (MDA) between the two groups (P < 0.05), all of which favored the study group. CONCLUSION: During nutrition treatment of ABP, preventing liver injury is very important. Glutathione combined with omega-3 polyunsaturated fatty acid and Dachengqi decoction can improve liver function, inflammatory factors and oxidative stress injury, and thereby reduce the incidence rate of liver injury in ABP patients. © 2015, Baishideng Publishing Group Inc. Source


Qu W.-F.,The Third Peoples Hospital of Wuxi City | Zhang W.-M.,The Third Peoples Hospital of Wuxi City | Ding X.-Y.,The Third Peoples Hospital of Wuxi City
World Chinese Journal of Digestology | Year: 2015

AIM: To evaluate the clinical effects of interleukin-12 (IL-12) induced killer cytokineinduced (CIK) combined with chemotherapy in patients with esophageal carcinoma. METHODS: Two hundred esophageal cancer patients treated at our hospital were randomly divided into a control group and a study group. All patients were treated with autologous CIK cell infusion and oxaliplatin. The CIK cells of the control group were induced with IFN-y, cd3mab, IL-2, and IL-1 in in vitro culture period, while those of the study group were induced with IL-12 IFN-y, CD3mAb, IL-2, and IL-1. After treatment, the clinical effects, the expression of T lymphocyte subsets, the CIK phenotype distribution and killing activity of CIK were compared between the two groups. RESULTS: The numbers of patients who achieved complete remission, partial remission and improvement in the study group were significantly more than those of the control group (P < 0.05); there was no significant difference in the number of patients with stable disease (P > 0.05); the number of patients with progressive disease was significantly more in the control group than in the study group (P < 0.05). After treatment, the percentages of peripheral blood CD3+, CD3+CD8+, CD3-CD16+CD56+, and CD3+CD16+CD56+ T cells were significantly higher in the study group than in the control group (P < 0.05), while that of peripheral blood CD3+ CD4+ T cells and the CD3+CD4+/ CD3+CD8+ ratio were significantly lower in the study group (P < 0.05). The percentages of CD3+CD4+ cells and CD3+CD16+CD56+ T cells and CD3+CD4+/CD3+CD8+ ratio in CIK cells were significantly lower, and the percentage of CD3+ CD8+ T cells was significantly higher in the study group than in the control group (P < 0.05). The cytotoxic activity of CIK cells in the study group was also significantly higher than that of the control group. CONCLUSION: IL-12 induced CIK cells combined with chemotherapy improve immune function and efficacy in patients with esophageal cancer. © 2015 Baishideng Publishing Group Inc. All rights reserved. Source

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