Wang K.-S.,Third Peoples Hospital Of Wuxi City |
Zhao L.,Third Peoples Hospital Of Wuxi City |
Zhou C.,Third Peoples Hospital Of Wuxi City
Chinese Journal of Tissue Engineering Research | Year: 2015
BACKGROUND: Intertrochanteric femoral fractures are one of the most common fractures in old patients. How to effectively fix has a great challenge for orthopedic surgeons. No consensus on which fixation method is optimal has been obtained in the academia. OBJECTIVE: To evaluate the clinical therapeutic effects and complications of minimally invasive percutaneous proximal femur locking compression plate for senile stable intertrochanteric fractures. METHODS: From May 2010 to May 2012, 98 patients (34 males and 64 females) with stable intertrochanteric fractures were treated with minimally invasive percutaneous proximal femur locking compression plate fixation. The mean age was 76 years (range, 59-93 years). The mean time between fractures and operation was 3 days (range, 1-5 days). Patients were followed up regularly after treatment. Healing time, Harris score of hip function recovery and the occurrence of complications were evaluated. RESULTS AND CONCLUSION: All patients were followed up for 12-24 months. All incisions obtained healing by first intention. All fractures reached clinical healing, and the healing time was 12-20 weeks (16 weeks on average). There was no fixation failure and loosing, rotation, crispatura deformity or screw cutting the femoral head. The function of the hip joint was assessed according to the Harris scoring: excellent in 75 cases and good in 18 cases, with the excellent and good rate of 95%. These data verify that proximal femur locking compression plate can be a feasible alternative to the treatment of stable intertrochanteric fractures. The patients obtained satisfactory outcomes, with less complication, indicating that there is a good biocompatibility between the implant and elderly host. © 2015, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.
Lyu G.,Third Peoples Hospital of Wuxi City
Chinese Journal of Burns | Year: 2015
Along with improvements in the embedding materials, continual innovation of the applied technique, and further understanding of therapeutic mechanism, the application scope of negative pressure wound therapy (NPWT) becomes broader, clinical experience in its use becomes more abundant. This issue of the journal highlights 5 papers to introduce the experience and knowledge regarding NPWT technique of the authors.
Gu M.-W.,Third Peoples Hospital Of Wuxi City |
Zhang Y.,Third Peoples Hospital Of Wuxi City |
Sun Z.-Y.,Third Peoples Hospital Of Wuxi City
World Chinese Journal of Digestology | Year: 2015
AIM: To investigate the effect of total glucosides of paeony (TGP) on rat hepatic injury after cardiopulmonary bypass (CPB) and the underlying mechanism. METHODS: Two hundred rats were randomly divided into a control group, a sham operation group, low-, medium- and high-dose TGP groups. Except the sham operation group, all other groups received CPB. In the low-, medium- and high-dose TGP treatment groups, 0.6, 1.2 and 1.8 mg/kg TGP was added into the priming solution, respectively. After 2 h of CPB, serum levels of transaminases, total bilirubin, prealbumin, transferrin, C-reactive protein, serum amyloid A, tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), IL-6, growth hormone (GH), growth hormone binding protein (GHBP), insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) were detected. Also, the expression of Na+/taurocholate cotransporting polypeptide (NTCP), bile salt export pump (BSEP) and farnesoid X receptor (FXR) in the liver was tested. RESULTS: Serum levels of glutamic pyruvic transaminase, aspartate transaminase, total bilirubin, prealbumin, transferrin, C-reactive protein, serum amyloid A protein, TNF-α, IL- 1β, and IL-6 were significantly higher in the control group after treatment than in the sham operation group (P < 0.05); however, these parameters were significantly lower in the three treatment groups than in the control group (P < 0.05). Serum levels of GH, GHBP, IGF-1 and IGFBP-3 as well as hepatic expression of NTCP, BSEP and FXR were significantly lower in the control group than in the sham operation group (P < 0.05); however, these parameters were significantly higher in the three treatment groups than in the control group (P < 0.05). There were significant differences in all parameters among the three treatment groups (P < 0.05). CONCLUSION: TGP can protect against liver injury caused by CPB in rats. © 2015 Baishideng Publishing Group Inc. All rights reserved.