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Zhou X.C.,Wenzhou Medical College | Hu K.Q.,Wenzhou Medical College | Zhang X.F.,Third Peoples Hospital of Hangzhou | Ye Y.H.,Wenzhou Medical College | And 4 more authors.
Head and Neck Oncology | Year: 2012

The thyroid gland is a relatively rare site for secondary malignancy. Here we describe the case of a 41-year-old woman with a history of bilateral breast cancer. She presented with elevated serum carbohydrate antigen 153 level. Ultrasonography revealed the bilateral thyroid lobes and isthmus diffuse distribution of point-like calcifications. No nodules were palpable, and total thyroidectomy was performed. A firm diagnosis of metastatic breast carcinoma to the bilateral thyroid was established. With this report, we could strengthen the argument that any patient with a thyroid lesion and a history of malignancy should be considered to have a metastasis until proven otherwise; further, we conclude that total thyroidectomy for the multifocality of metastases to the thyroid gland is feasible when metastatic cancer is limited to the thyroid. With a combination of comprehensive treatments, such as chemotherapy, radiotherapy and endocrine therapy, the survival of the patient can be prolonged. Copyright © 2012 OA Publishing London.

Dai X.-Y.,Third Peoples Hospital of Hangzhou | Yan Y.-L.,Zhejiang Chinese Medical University | Wu Q.-F.,Zhejiang Chinese Medical University | Yu C.-H.,Zhejiang Academy of Medical science | And 2 more authors.
Journal of Ethnopharmacology | Year: 2014

Ethnopharmacological relevance Quyu Qingre granules (QYQRGs) are useful traditional Chinese composite prescription in the treatment of blood stasis syndrome. Comparing differences of pharmacokinetic properties of compounds in QYQRG between normal and blood stasis syndrome rabbits can provide much helpful information. The primary objective of this study was to compare the pharmacokinetics of rhein and chrysophanol after orally administering 2.0 g/kg b.w. QYQRG in normal and acute blood stasis model rabbits. Materials and methods The blood samples were collected subsequently at 5, 10, 15, 20, 30, 45, 60, 75, 90, 120, 240, 360 and 480 min after orally administrating QYQRG. The concentrations of rhein and chrysophanol in rabbit plasma were determined by HPLC and main pharmacokinetic parameters were obtained. Results The pharmacokinetic parameters AUC0-∞, Tlag, C max and K21 of both rhein and chrysophanol were markedly different in the acute blood stasis model rabbits. It was also found that parameters A, β, MRT and T1/2β of rhein and the parameters α and T1/2α of chrysophanol all exhibited significant difference between the normal and acute blood stasis model rabbits. Conclusions The absorption time of rhein and chrysophanol was accelerated and the absorption amount of these two compounds was increased in rabbits with acute blood stasis, suggesting that rhein and chrysophanol would possibly be the two effective compounds in QYQRG. © 2014 Elsevier Ireland Ltd.

Su-Hong C.,Zhejiang Chinese Medical University | Su-Hong C.,Wenzhou University | Qi C.,Third Peoples Hospital of Hangzhou | Bo L.,Zhejiang Chinese Medical University | And 4 more authors.
Evidence-based Complementary and Alternative Medicine | Year: 2015

Radix Paeoniae Alba (Baishao, RPA) has long been used in traditional Chinese medicine formulation to treat hypertension by repression the hyperfunction of liver. However, whether the RPA itself has the antihypertensive effect or not is seldom studied. This study was to evaluate the protective effect of RPA on hypertensive rats. Alcohol in conjunction with a high fat diet-(ACHFD-) induced hypertensive rats and spontaneously hypertensive rats (SHR) was constantly received either RPA extract (25 or 75 mg/kg) or captopril (15 mg/kg) all along the experiments. As a result, RPA extract (75 mg/kg) could significantly reduce systolic blood pressure of both ACHFD-induced hypertensive rats and SHR after 9-week or 4-week treatment. In ACHFD-induced hypertensive rats, the blood pressure was significantly increased and the lipid profiles in serum including triglyceride, total cholesterol, LDL-cholesterol, and HDL-cholesterol were significantly deteriorated. Also, hepatic damage was manifested by a significant increase in alanine transaminase (ALT) and aspartate transaminase (AST) in serum. The RPA extract significantly reversed these parameters, which revealed that it could alleviate the liver damage of rats. In SHR, our result suggested that the antihypertensive active of RPA extract may be related to its effect on regulating serum nitric oxide (NO) and endothelin (ET) levels. © 2015 Chen Su-Hong et al.

Zhang X.,Anhui Medical University | Zhang X.,Fudan University | Tang H.,Anhui Medical University | Jin X.,Anhui Medical University | And 67 more authors.
Nature Genetics | Year: 2014

To explore the contribution of functional coding variants to psoriasis, we analyzed nonsynonymous single-nucleotide variants (SNVs) across the genome by exome sequencing in 781 psoriasis cases and 676 controls and through follow-up validation in 1,326 candidate genes by targeted sequencing in 9,946 psoriasis cases and 9,906 controls from the Chinese population. We discovered two independent missense SNVs in IL23R and GJB2 of low frequency and five common missense SNVs in LCE3D, ERAP1, CARD14 and ZNF816A associated with psoriasis at genome-wide significance. Rare missense SNVs in FUT2 and TARBP1 were also observed with suggestive evidence of association. Single-variant and gene-based association analyses of nonsynonymous SNVs did not identify newly associated genes for psoriasis in the regions subjected to targeted resequencing. This suggests that coding variants in the 1,326 targeted genes contribute only a limited fraction of the overall genetic risk for psoriasis. © 2014 Nature America, Inc.

Guan C.,Third Peoples Hospital of Hangzhou | Lin F.,Zhejiang Sci-Tech University | Zhou M.,Third Peoples Hospital of Hangzhou | Hong W.,Third Peoples Hospital of Hangzhou | And 5 more authors.
International Journal of Molecular Medicine | Year: 2010

Our previous study has shown that VIT1 gene in Chinese vitiligo patients is de facto the FBXO11 gene, and the silencing of that gene has an impact on the ultrastructure of melanocytes. In this study, we further identified the role of the FBXO11 gene in melanocytes and the relationship between dilated endoplasmic reticulum (ER) and tyrosinase by inhibition and overexpression of FBXO11 gene. Cell proliferation, apoptosis, cycle and migration of melanocytes were examined when the FBXO11 gene was silenced or overexpressed. The results showed that FBXO11 gene promoted cell proliferation and suppressed cell apoptosis, and yet had little effect on cell migration. Obvious swelling of ER was found in the cells transfected with siRNA of FBXO11 gene. Interestingly, protein level of tyrosinase was extraordinarily high following inhibition of FBXO11 gene. Further examination revealed that tyrosinase and calreticulin were co-localized in ER of transfected cells following siRNA of FBXO11 gene, suggesting that tyrosinase could not be exported from ER effectively. Collectively, our results support the notion that FBXO11 plays an important role in regulating proliferation and apoptosis of melanocytes, and functional export of tyrosinase from ER in vitiligo melanocytes.

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