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Zeng C.,Third Peoples Hospital of Chengdu | Zhou H.,Sichuan Cancer Hospital | Wei Y.,Sichuan Cancer Hospital | Wang L.Y.,Sichuan Cancer Hospital | And 2 more authors.
Chinese Medical Journal | Year: 2014

Background Studies have shown that irinotecan can improve survival in patients with advanced or recurrent gastric cancer, but the overall benefit of irinotecan in the treatment of advanced or recurrent gastric cancer remains controversial. The aim of this study was to evaluate the benefits and risks of irinotecan for survival in patients with advanced or recurrent gastric cancer. Method We searched PubMed, EmBase, the Cochrane Central Register of Controlled Trials, reference lists of articles, and proceedings of major conferences for relevant clinical trials. We included randomized controlled trials that reported on the efficacy and safety of irinotecan in patients with advanced or recurrent gastric cancer. Outcomes were analyzed by survival rate, objective response rate (ORR), and toxicity. Furthermore, the analysis was further stratified by factors that could affect the treatment effects. Results Eight trials recruiting 1 546 patients with advanced or recurrent gastric cancer were included in the analysis. Overall, irinotecan therapy was associated with a 6% improvement in survival rate, but this difference was not statistically significant (odds ratio (OR) 0.94; 95% confidence interval (95% CI) 0.70-1.27; P=0.69). However, irinotecan therapy had more frequent ORR than irinotecan-free arm (OR 1.70; 95% CI 1.34-2.17; P <0.001). Furthermore, irinotecan therapy was associated with a clinically and statistically significant increase in the risk for declined hemoglobin, hyponatremia, and diarrhea, but it also protected against thrombocytopenia risk when compared with irinotecan-free therapy. Conclusions There is no evidence to support the use of irinotecan therapy in patients with advanced or recurrent gastric cancer; however, given the significant advantage in ORR irinotecan therapy using combination regimens may be considered for further evaluation in subsets of patients who may benefit from this treatment. Source

Wang B.,University of Sichuan | He P.,Third Peoples Hospital of Chengdu | Dong B.,University of Sichuan
Archives of Gerontology and Geriatrics | Year: 2015

Objective: To explore the associations between social networks, social contacts, and cognitive impairment in the very elderly aged 90-108 years. Methods: Data were from subjects of the Project of Longevity and Ageing in Dujiangyan, China. The socio-demographic, social networks, and social contacts data were collected and cognitive function was assessed in all subjects using the Mini-Mental State Examination (MMSE). Results: 764 Chinese nonagenarians and centenarians (67.41% women, mean age 93.47 years) were included. The mean MMSE score was 14.99. ±. 5.93). The prevalence of cognitive impairment was 64.53%. The mean social contact score was 4.37. ±. 1.86. There were significantly different cognitive function scores among individuals with different marital status, number of close friends, and different social contact levels (all P<. 0.05). Spearman rank correlation analysis showed that number of close friends and social contact scores were significantly positively but single status was significantly negatively correlated with the MMSE scores (all P<. 0.05). Multiple logistic regression analysis showed that there were associations between single status, no close friend, and low level of social contact with cognitive impairment (all P<. 0.05), but not other social network variables. Conclusion: Single status, no close friend, and low level of social contact were associated with increased risk of cognitive impairment in Chinese nonagenarians and centenarians. Our finding might add new information for social networks, social contacts, and cognitive research in the elderly. © 2015 Elsevier Ireland Ltd. Source

Lei W.,Peoples Hospital of Mianzhu | Liu Y.-E.,New Era Stroke Care and Research Institute | Zheng Y.,Third Peoples Hospital of Chengdu | Qu L.,Design Institute of Chengdu Military Region
Medical Science Monitor | Year: 2015

Background: Oral squamous cell carcinoma (OSCC) is the sixth most common human malignancy worldwide. To develop new therapeutics requires elucidation of the underlying mechanism of OSCC pathogenesis. The role of miR-429 in OSCC remains unknown.Material/Methods: The level of miR-429 and ZEB1 in OSCC tissues and cell lines was measured by qRT-PCR. MiR-429 was downregulated by miRNAs antisense oligonucleotides (ASO) transfection and up-regulated by miRNAs mimics. Cell proliferation was analyzed by MTT assay. Cell apoptosis was revealed by FACS analysis. Targeted genes were predicted by a bioinformatics algorithm and confirmed by a dual luciferase reporter assay.Results: MiR-429 was down-regulated in OSCC tissues, and miR-429 overexpression inhibited OSCC cell lines growth and vice versa. Further, we found that miR-429 could inhibit zinc finger E-boxbinding homeobox 1 (ZEB1) expression, and that miR-429 and ZEB1 expression in OSCC tissues were negatively correlated.Conclusions: Our data demonstrate the tumor suppressor role of miR-429 in OSCC, and may provide a potential therapeutic target that warrants further investigation. © Med Sci Monit. Source

Gu J.,Zhenjiang First Peoples Hospital | Han L.,Third Peoples Hospital of Chengdu | Liu Q.,Jiangsu University
Journal of Central South University (Medical Sciences) | Year: 2013

Objective: To evaluate the efficacy and safety of combined treatment with angiotensin II receptor blocker (ARB) and angiotensin converting enzyme inhibitor (ACEI) on diabetic kidney disease. Methods: Randomized controlled trials (RCTs) were identified from CoChrane library, PubMed, EMbase, CNKI and VIP. Eleven RCTs involving 602 patients were included and analyzed with Rev Man 5.1 software. Results: Compared with ACEI alone, combined treatment with ARB and ACEI was more effective on decreasing 24 h albuminuria, systolic pressure, average 24 h systolic pressure, diastolic pressure, and average 24 h diastolic pressure but with a high level of serum potassium. Compared with ARB alone, combined treatment with ARB and ACEI was more effective on decreasing systolic pressure and diastolic pressure. Compared with ACEI or ARB alone, we didn't get a definite conclusion that whether combined treatment with ARB and ACEI was more effective on decreasing 24 h proteinuria. Conclusion: Based on this Meta analysis, combined treatment with ARB and ACEI is safer and has positive effect on diabetic kidney disease. However, small sample size and low methodological quality appeared in most of the trials included in this systematic review. Therefore, available evidence is insufficient to recommend a routine clinical application of combined treatment with ARB and ACEI on diabetic kidney disease. Source

Zhang X.,Chengdu University of Technology | Du Q.,Nanjing Medical University | Liu C.,Nanjing Medical University | Yang Y.,Third Peoples Hospital of Chengdu | And 3 more authors.
International Immunopharmacology | Year: 2016

Rhodioloside, a major constituent from roots of Rhodiola rosea, has been previously confirmed to alleviate the hyperactivity in olfactory bulbectomized (OBX) rats exposed to the open field and to decrease the immobility time in the forced swimming test (FST) and tail suspension test (TST). However, its antidepressant effects and mechanisms remain unclear. This study aimed to evaluate the antidepressant effect and the potential mechanisms of rhodioloside in OBX rats. ELISA kits, HPLC-MS and western blot analysis were applied to explore the underlying antidepressant mechanisms of rhodioloside. Rhodioloside (20, 40 mg/kg) significantly reversed OBX-induced reduction in sucrose consumption. It was also observed that administration of rhodioloside (20, 40 mg/kg) decreased pro-inflammatory cytokines interleukin-1 beta (IL-1β) and interleukin-6 (IL-6) levels and inhibits nuclear factor-kappa B (NF-κB) activation, as well as normalized the monoaminergic system changes in prefrontal cortex (PFC) of OBX rats. These results confirmed the antidepressant-like effect of rhodioloside, which might be primarily based on its up-regulation of the monoaminergic system activity and anti-inflammatory effect. © 2016 Elsevier B.V. Source

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