Li M.,Wayne State University |
Hu J.,Wayne State University |
Miao Y.,Dalian Medical University |
Shen H.,Capital Medical University |
And 7 more authors.
PLoS ONE | Year: 2013
Background and Purpose:Cerebral blood oxygenation level is critical for following the evolution of stroke patients. The purpose of this study was to investigate the feasibility of measuring changes in blood oxygen levels for patients with acute stroke using SWI and to compare these changes with the patient's recovery over time.Materials and Methods:A total 30 MRI scans was performed on 10 acute ischemic stroke patients. Every patient was followed at three time points: less than 24 hours; 2-3 weeks after stroke and 2 months after stroke. Both MRI scan and NIH stroke scale (NIHSS) were acquired for each patient at all three time points. Oxygen saturation changes were derived from phase values differences (Δφ) measured over 10 veins from each hemisphere for all 10 patients over 3 time points. The correlation of oxygen saturation and NIHSS was further evaluated.Results:The stroke affected side of the brain showed moderate (r = -0.62) to strong (r = -0.70) correlation between the oxygenation change and NIHSS change. The oxygen saturation change from the normal side of the brain had essentially no association with recovery (r = -0.02 and-0.31). The results suggest that increases in oxygen saturation correspond to improved outcome and reductions in oxygen saturation correspond to worse outcome.Conclusion:High resolution SWI provided a novel method to measure changes in oxygenation change of the human brain in vivo. By using the phase values from the veins, both spatial and temporal information can be found that relates to patient outcome post stroke. © 2013 Li et al.
Yang Z.-H.,Third Hospital of Xingtai |
Li X.,Third Hospital of Xingtai |
Wang X.-G.,Third Hospital of Xingtai |
Yang X.-Y.,Third Hospital of Xingtai |
And 3 more authors.
Journal of Dalian Medical University | Year: 2015
Objective: To investigate the susceptibility-weighted imaging (SWI) characters in the massive cerebral infarction and evaluate the role of SWI in prognostic assessment of the large ischemia stroke. Methods: 43 patients with massive cerebral infarction, defined by the Adamas rules as the infarction diameters were bigger than 3 cm2, and related to more than two main vascular territory, were performed SWI within 7 days, 2 weeks and 3 months. Clinical function scores were acquired with the NIHSS. Characteristics of routine MRI and SWI images were analyzed. Presence of hemorrhage and correlated arterial thrombosis and collateral circulation after massive cerebral infarction were studied. Correlation of imaging and NIHSS score changes was analyzed. Results: Hemorrhage was revealed by SWI in 34 out of 43 (79%) massive cerebral infarction. There was a negative correlation between the extent of hemorrhage and the change of NIHSS scores (P <0. 01). Arterial thrombosis was found in 30 cases (70%). The proximal location of the thrombosis to the cerebral necrosis and the thrombus length were negatively correlated to the change of NIHSS scores (P < 0.01). Collateral circulation was seen in 31 cases (72%). There was a positive correlation between the extent of collateral circulation displayed in the SWI and the change of NIHSS scores (P <0.01). Conclusion: SWI can show the hemorrhage, correlated arterial thrombosis and the collateral circulation of massive ischemic stroke and can be used to measure the changes, thus is helpful in guiding the clinical prognosis.
Yang Z.-H.,Third Hospital of Xingtai |
Wu J.-L.,Dalian University
Journal of Dalian Medical University | Year: 2014
Objective: To analyze the features of susceptibility - weighted imaging (SWI) of leptomeningeal collaterals in ischemia stroke and its clinical correlation.Methods: Totally 66 patients with clinically or radiologically proved cerebral infarction, including 26 acute, 29 subacute and 11 chronic cerebral infarction, were examined with MRI. All patients received conventional sequences including Tl WI, T2WI, FLAIR, DWI and SWI. Twenty - seven patients underwent MRA, and 36 patients were followed by SWI. Features of routine MRI and SWI were studied. The presence of leptomeningeal collaterals around the infarction was observed. The correlation between the extent of the leptomeningeal collateral and the NIH-SS score was analyzed.Results: Leptomeningeal collateral was revealed by SWI in 45 out of 66 (68%) cerebral infarctions, including 41 cases in acute and subacute cerebral infarction, and 4 cases in stable and chronic stage. The visualization of collateral vessels around the infarction in different stages has significant difference (P < 0. 05). Twenty cases showed degree 2 collaterals. There was a positive correlation between the degree of leptomeningeal collateral displayed in the SWI and the NIHSS scores (r, =0. 673, P <0.01).Conclusion: Quantitative analysis of SWI features of leptomeningeal collaterals in ischemic stroke can help determine the establishment of collateral circulation of cerebral infarction, guide the clinical treatment and evaluate the prognosis.