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Peng Y.-B.,Third Hospital of Chinese PLA | Mao X.-L.,Third Hospital of Chinese PLA | Wang X.-F.,Third Hospital of Chinese PLA | Yang S.-Z.,Third Hospital of Chinese PLA | And 2 more authors.
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2010

BACKGROUND: Digital three-dimensional reconstructed titanium mesh can best achieve physiologic and anatomical molding during large defect of skull in the frontotemporal area. OBJECTIVE: To compare the clinical effect of digital three-dimensional reconstructed titanium mesh and manual modeled titanium mesh for cranioplasty of defect of skull. METHODS: A total of 109 patients with skull defect were randomly assigned to two groups according to different methods: 60 patients with large skull defect were repaired with manual shaped titanium mesh, and 49 patients with digital three-dimensional reconstructed titanium mesh. Titanium mesh was made into individual skull prosthetic replacement by computer three-dimensional reconstruction. RESULTS AND CONCLUSION: The operation time, the incidence rate of complication and the degree of moulding satisfaction were 108 minutes, 22% and 67% in the manual modeled group, which were 78 minutes, 4% and 100% in the digital three-dimensional reconstructed group respectively. In the digital three-dimensional reconstructed group, the operation time was shorter and the incidence rate of complication was fewer, while the degree of moulding satisfaction was significantly higher than the manual modeled group (P < 0.05). Results have shown that digital three-dimensional reconstructed titanium mesh can save surgical duration, with less postoperative complications and have high satisfaction in cranioplasty. Source


Cheng Y.-C.,Third Hospital of Chinese PLA | Li Y.,PLA Fourth Military Medical University | Xu C.-T.,PLA Fourth Military Medical University | Xu L.-X.,PLA Fourth Military Medical University | Pan B.-R.,PLA Fourth Military Medical University
International Journal of Ophthalmology | Year: 2011

AIM: To compare the effect of propofol versus urapidil on hemodynamics and intraocular pressure during anesthesia and extubation for ophthalmic patients. METHODS: Eighty-two surgical patients (Class: ASA I-II) were randomly assigned to propofol (n=41 ) and urapidil groups (n=41 ). Their gender, age, bodymass, operation time and dosage of anesthetics had no significant difference between the two groups (P>0.05 ). The patients of propofol and urapidil groups were given propofol (1.5 m g/kg) and urapidil (2.5 m g/kg) respectively ; and two drugs were all diluted with normal saline to 8mL. Then the drugs were given to patients by slowintrav enous injection. After treatment, the patients were conducted immediate suction, tracheal extubation, and then patients woreoxy genmasks for 10minutes. By double-blind m ethods, before the induction m edication, at the suction, and 5 , 1 0 minutes after the extubation, werecorded the systolic and diastolic blood pressure (BP), heart rate (HR), pH, PaO 2, PaCO2, SaO2 and intraocular pressure (IOP) respectiv ely . The complete recovery time of the patients with restlessness (on the com m and they could open eyes and shaking hands) was also recorded during the extubation. The data were analyzed by using a professional SPSS 15.0 statistical software. RESULTS: The incidence of cough, restlessness and glossocom a was significantly lower in the propofol group than that in the urapidil group after extubation (P<0.05 ). There were no episodes of hy potension, laryngospasm , or severe respiratory depression. There was no statistical difference in recovery time between two groups (P>0.05 ). In propofol group, the BP and HR during extubation and thereafter had no significant difference compared with those before induction, while they were significantly lower than those before giving propofol (P<0.05 ), and had significant difference com pared with those in urapidil group (P<0.05 ). Compared to preinduction, the BP of urapidil group showed no obvious increase during aspiration and extubation. The HR of urapidil group had little changes after being given urapidil, and it was obviously increased com pared with that before induction. The stimulation of aspiration and extubation caused less cough and agitation in propofol group than that in urapidil group (P<0.05 ). The IOP of propofol group showed no obv ious increase during extubation com pared with that in preinduction, while in the urpidil group, extubation caused IOP significantly increased (P<0.05 ). The changes in these indicators between the two groups had no significant difference (P>0.05 ). CONCLUSION: Compared to urapidil, propofol is superior for preventing the cardiovascular and stress responses and IOP increases during emergence and extubation for the ophthalmicpatients. Moreover, it has no effects on patient's recovery. © International Journal of Ophthalmology Press. Source


Wang X.,Third Hospital of Chinese PLA | Zhang R.,Third Hospital of Chinese PLA | Tang Z.,Third Hospital of Chinese PLA | Liu J.,Third Hospital of Chinese PLA | And 5 more authors.
Turkish Neurosurgery | Year: 2014

Aim: To investigate clinical factors that may influence the decision to preserve or remove the bone flap during the craniectomy surgery for patients of traumatic brain injury. Material and Methods: Clinical data from 2256 TBI patients were quantitatively analyzed and scored based on multiple clinical factors, including preoperative Glasgow Coma Scale (GCS) score, changes in pupil size, hematoma volume, time interval between injury and surgery, midline shift on CT scan, hematoma location and type, cortical collapse and the lateral ventricular shift deformation. Results: We identified several independent factors in the decision to preserve the bone flap: GCS score and pupil changes before the operation, cortical collapse, injury/surgery time interval and hematoma location. The results suggested that for patients with a combined score of =55, their bone flap was generally retained. For cases with a score of 50-55, the surgical decision was based on the patient level of preconscious status, changes in pupil size and the extent of postoperative cortical collapse, and for patients with a score <50, the bone flap was generally removed. Conclusion: Our scoring scheme is to identify factors that may be helpful when determining whether to remove or retain bone flap of TBI patients. Source


Zhang R.,Third Hospital of Chinese PLA | Wang X.,Third Hospital of Chinese PLA | Liu J.,Third Hospital of Chinese PLA | Yang S.,Third Hospital of Chinese PLA | And 7 more authors.
Genetic Testing and Molecular Biomarkers | Year: 2012

Prior studies investigating the association between apolipoprotein E (APOE) gene polymorphism and the risk of intracerebral hemorrhage (ICH) have been inconsistent and limited to small sample sizes. The aim of this study was to test the hypothesis that APOE gene polymorphisms are associated with the risk of ICH in Chinese Han patients. We enrolled 180 ICH patients and 180 controls. APOE genotype was determined by using a polymerase chain reaction-restriction fragment length polymorphism assay. ICH patients had a significantly lower frequency ε3/ε3 [odds ratio (OR)=0.45, 95% confidence interval (CI)=0.28, 0.71; p=0.001] and ε3 allele (OR=0.51, 95% CI=0.35, 0.76; p=0.001) than healthy controls. ICH patients also had a significantly higher frequency ε3/ε4 (OR=3.61, 95% CI=1.89, 6.88; p<0.001) and ε4 allele (OR=3.00, 95% CI=1.76, 5.13; p<0.001) than healthy controls. This study suggests that the APOE genotype is associated with the risk of ICH in Chinese Han patients. © 2012 Mary Ann Liebert, Inc. Source


Zhang R.,Third Hospital of Chinese PLA | Wang X.,Third Hospital of Chinese PLA | Tang Z.,Third Hospital of Chinese PLA | Liu J.,Third Hospital of Chinese PLA | And 8 more authors.
Lipids in Health and Disease | Year: 2014

Background: Studies investigating the association between the apolipoprotein E (APOE) gene polymorphism and the risk of intracerebral hemorrhage (ICH) have reported conflicting results. We here performed a meta-analysis based on the evidence currently available from the literature to make a more precise estimation of this relationship. Methods. Published literature from the National Library of Medline and Embase databases were retrieved. Odds ratio (OR) and 95% confidence interval (CI) were calculated in fixed- or random-effects models when appropriate. Subgroup analyses were performed by race. Results: This meta-analysis included 11 case-control studies, which included 1,238 ICH cases and 3,575 controls. The combined results based on all studies showed that ICH cases had a significantly higher frequency of APOE 4 allele (OR= 1.42, 95% CI= 1.21,1.67, P<0.001). In the subgroup analysis by race, we also found that ICH cases had a significantly higher frequency of APOE 4 allele in Asians (OR= 1.52, 95% CI= 1.20,1.93, P<0.001) and in Caucasians (OR= 1.34, 95% CI= 1.07,1.66, P=0.009). There was no significant relationship between APOE 2 allele and the risk of ICH. Conclusion: Our meta-analysis suggested that APOE 4 allele was associated with a higher risk of ICH. © 2014 Zhang et al.; licensee BioMed Central Ltd. Source

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