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Guo T.,Hebei University | Hu J.W.,Hebei University | Wang X.H.,Hebei University | Jin L.H.,Hebei University | Wang Y.Z.,Third Brigade
Yanshi Xuebao/Acta Petrologica Sinica | Year: 2016

An accurate cubic equation of state for supercritical water is developed on the basis of the pressure-volume-temperature (PVT) data from the highly accurate thermodynamic formulations IAPWS-95 and IAPWS-IF97. In the range 723. 15-2273. 15K and 0 ∼1.4GPa, its average volume deviation is only 0.26%. It can also be used outside the range up to 4273. 15K and 2GPa with an average volume deviation of less than 2%. It is significantly superior to previous cubic equations of state in both accuracy and applicable P-T range. It is also obviously superior to the commonly used non-cubic equations (mostly high-order virial type equations) with many temperature-dependent parameters under comparable P-T conditions. According to the above cubic equation and relevant thermodynamic theorems, analytical expressions are derived for compression and expansion coefficients, fugacity coefficient, as well as residual enthalpy and entropy, whose calculated results agree very well with those of the IAPWS-95 formulation. With these results, many other thermodynamic properties can be calculated easily.

Xue Q.,Chinese PLA General Hospital | Wang H.,Third Brigade | Wang J.,Chinese PLA General Hospital
European Journal of Clinical Microbiology and Infectious Diseases | Year: 2010

Recurrent respiratory papillomatosis (RRP) primarily caused by human papillomas virus is a rare and benign neoplasm, primarily involving the epithelium mucosae of the respiratory tract. RRP may occur anywhere in the respiratory tract with a predilection to the laryngeal area and may potentially threaten life. Because of the absence of specific clinical manifestations, the diagnosis of this disease is easily delayed. The high awareness of RRP and performing endoscopy as soon as possible in suspected patients are the prerequisites for early diagnosis. Surgical removal on endoscope is still a fundamental treatment. Adjuvant treatment is required only in some patients. Because of the potential of malignant transformation and recurrence, careful follow-up for RRP is required for early detection and treatment. © 2010 Springer-Verlag.

Mei Q.,Third Brigade | Zhou D.,Third Brigade | Gao J.,Nanjing Medical University | Shen S.,University of Sichuan | And 3 more authors.
BMC Cancer | Year: 2012

Background: MTHFR 677C>T polymorphism is a genetic alteration in an enzyme involved in folate metabolism, but its effect on host susceptibility to cervical cancer is still uncertain. The aim of this study was to investigate the association between MTHFR 677C>T polymorphism and cervical cancer by performing a meta-analysis.Methods: Pubmed, Embase, Web of Science, and the Chinese Biomedical Database (CBM) databases were searched for case-control studies investigating the association between MTHFR 677C>T polymorphism and cervical cancer. Odds ratios (OR) and 95% confidence intervals (95%CI) were used to assess this possible association.Results: 11 studies with a total of 1898 cervical cancer cases and 2678 controls were included. Meta-analyses of a total 11 studies showed no association between MTHFR 677C>T polymorphism and cervical cancer using all five genetic models (All P values > 0.05). However, subgroup analyses showed the odds of the homozygous TT genotype were much less in cervical cancer cases than in controls in Europeans, which implied an association between the homozygous TT genotype and cervical cancer in Europeans (For TT versus CC, fixed-effects OR = 0.65, 95%CI 0.45-0.93, P = 0.020, I2 = 0.0%). The odds for the homozygous TT genotype were greater in cervical cancer cases than in controls in East Asians, which also implied an association between the homozygous TT genotype and cervical cancer in East Asians (For TT versus CC, random-effects OR = 1.66, 95%CI 1.05-2.62, P = 0.029, I2 = 52.6%; For TT versus CT/CC, random-effects OR = 1.55, 95%CI 1.09-2.22, P = 0.016, I2 = 42.4%). Both subgroup analyses and meta-regression analyses suggested ethnicity was the major source of heterogeneity. Publication bias was not evident.Conclusions: This meta-analysis supports an association between MTHFR 677C>T polymorphism and cervical cancer, and the effect of this association may be race specific. Further studies with large sample sizes and careful design are needed to identify this association more comprehensively. © 2012 Mei et al.; licensee BioMed Central Ltd.

News Article | April 30, 2009
Site: www.techworld.com

Trend Micro has confirmed it is acquiring the Canadian intrusion-prevention and firewall software provider, Third Brigade, for an undisclosed sum. Trend Micro has had a close partnership with Third Brigade for two years in which Trend has integrated Third Brigade's host-based intrusion-prevention/firewall software into the Trend OfficeScan product line. Trend Micro said it would hold a press conference to discuss the acquisition but in a statement earlier on Wednesday, CEO Eva Chen said acquiring Third Brigade will "accelerate ongoing efforts to deliver innovative solutions that are uniquely suited to dynamic data centres." Wael Mohamed, president and CEO of Third Brigade, founded in 2004, said Trend Micro and Third Brigade share a "common vision," adding that Third Brigade, as part of Trend, will benefit from the buyer's "substantial industry, channel and financial strengths." The deal is expected to close during the second half of this year.

News Article | July 1, 2015
Site: www.finsmes.com

Some days ago, Toronto, Ontario, Canada-based venture capital firm Whitecap Venture Partners announced the close of its third fund at $100m in commitments for its third fund. Following the announcement, we had the opportunity to make some questions to Joe Catalfamo, one of the partners, about the targets of the firm and opportunities ahead. He also shared with us some thoughts about the Canadian ecosystem and the future of the tech world. FinSMEs: Hi Joe, tell us a bit more about you…what’s your background? Joe: I’m a partner at Whitecap Venture Partners, working alongside two other partners – Carey Diamond and Blaine Hobson – and two key principals (Russell Samuels and Shayn Diamond). While Russell and Shayn joined our investment team at the outset of launching Whitecap III, my partners Carey, Blaine and I have a long standing history of working well together and backing many special people that went on to build world class companies. In Canada, the three of us are among the grey hairs of the industry and one of the few groups that has been consistently successful in this asset class over the past few decades. My primary focus has been on mobile, enterprise software, video and data markets. In addition to some of these areas, my partners have also built some great competencies in Med Tech and Food Tech. FinSMEs: What’s Whitecap Venture Partners? Joe: Whitecap Venture Partners is an early stage venture capital fund investing in high growth companies across three verticals: Information and Communications Technologies (ICT), Food Tech, and Med Tech. The Whitecap Venture Partners team is a group of former operators and investors who have invested together for more than 25 years. We partner with entrepreneurs in verticals where we have deep domain expertise and can bring significant operational and strategic value to companies. Whitecap Venture Partners began as the Venture Capital arm of Whitecastle Investments Ltd., the Diamond family office operating in Toronto. The Diamond family, with its roots in real estate development, has a long history of VC investing in Canada. They were pioneers in this ecosystem, helping to launch some of the first VC funds in the beginning of the 1990s before advocating a direct investment only strategy, which was unique in Canada for a family office. The firm has a longstanding tenure in this industry and is among the very few venture groups that have been investing since the early 1990s with the same or similar team. Whitecap III is the first technology venture fund for the Diamond family that also takes in non-family capital under management. FinSMEs: You just closed the third fund…was it hard to raise? Who supported it? Joe: We certainly recognize it is a difficult venture fund raising environment in Canada, where typically it can take 18 months or longer to fully raise a fund due to the lack of liquidity in the system for this asset class and competition for that capital. We were, understandably, very pleased with the strong market reception, which enabled us to fully raise our $100 Million fund in 120 days. We believe this is a function of the significant commitment of the Diamond Family and managers, which was far greater than the norm; and our ability to successfully market to sophisticated family offices, which we see as a new and sustainable inflow of risk capital into venture for Canada. To successfully market to these families, we believe you need three key things: (1) Talented and experienced team; (2) top investment performance; and, (3) only be one standard deviation removed from a relationship of trust. Committing a significant amount of our money is important to that trust relationship, as they know we treat their money as if it is our own. Our LPs include Kensington Venture Fund under the Canadian Venture Capital Action Plan program, the Bank of Montreal (BMO), and a number of high net-worth families that represent in aggregate nearly 50% of the fund. FinSMEs: Can you share which high net-worth Canadian families are LPs in Whitecap III? Joe: We cannot as, understandably, they wish to remain anonymous. Suffice to say they are sophisticated and entrepreneurial groups that are known to the family and excited about supporting new innovation. They are also insightful and well-connected groups we hope to reach out to from time to time to tap their knowledge, relationships, and opinions in support of our investment strategy. FinSMEs: what’s the fund (overall) strategy? Joe: We are looking to invest in companies that are ready for Series A funding, but we are not limited to that (we expect to invest in selective seed and later stage opportunities). We like to focus on special people driving the next innovation cycle for our target areas of focus, which are ICT, med tech and food tech; companies that have the wherewithal to define and lead new product categories. Having a seat on the board and a productive relationship with management is a must for all our investments, as it is core to a high touch, value-add operating model that influences strategy, corporate and business development work, team mentoring or team building work, etc. in partnership with the management team. Whitecap I was focused on the ICT market, including wireless, video, enterprise software, and Internet infrastructure. Whitecap II was primarily focused on Food Tech, Med Tech and ICT. Whitecap III builds on our experiences in all three markets; we like the diversified fund focus as it plays well in our local target markets with a focus on sub-verticals where we have not only built domain knowledge, but have also been successful. Practically, we want to meaningfully invest in 10-14 category defining companies with this fund cycle. We expect this to include a mix of backing repeat entrepreneurs and first time entrepreneurs, which mostly defines the Canadian Venture landscape. FinSMEs: Will you only be investing in Canadian companies? Joe: We think the VC landscape has never been better suited for building a world-class company based in Canada. This is very different than the late 90’s where there was a direct correlation between success and a California postal code. As we would like to be involved and available to our portfolio companies, we have made the decision to focus on businesses that are within a three-hour flight radius of our office here in Toronto. That means we will be looking at companies in markets that include Winnipeg in the west and Atlantic Canada in the east. While our primary focus will be on Canada, we may also look at some businesses in the northeast U.S. that fit our fund focus. FinSMEs: What do you like to see in entrepreneurs before backing them? Can you make some examples from your experience? Joe: Simply, brilliant people with a vision, strong leadership, clear solution path to a large market problem and a plausible means to tackle it. I think our advisory board members represent some of the best examples of exceptional entrepreneurs and business leaders from the formative ventures Whitecap’s partners have previously backed. These include Marcel LeBrun, former co-founder and CEO of Radian6 and iMagicTV; Jason Smith, CEO of Real Matters and Basis 100; and Wael Mohamed, COO and director of Trend Micro and former co-founder and CEO of Third Brigade and key executive at Entrust. Over the decades we have been fortunate to have backed (and often as the first institutional investor) some impressive people that have pioneered and built several world-class companies that were Canadian venture backed. Not only do we hope to partner again with those entrepreneurs and teams that have flourished under our mentoring, but also value how these lifelong experiences have helped us refine the lens we use to select first time entrepreneurs as our partners. Special people always have a multitude of options, and we are mindful of the fact they are choosing to partner with us as well, making the relationship mutually beneficial. FinSMEs: Trends….what will be hot in the next few years? Joe: We are thesis driven in our investment approach, but identifying trends must be filtered by what new company generation we are seeing in our local target markets. The very good news for Canada is the degree to which new innovation has prospered across the board the past decade due in part to a strong academic environment, robust incubation landscape, strengthening GP landscape, and several notable success stories that create passion and fuel for innovation right across the value chain. We still find that there is a funding gap at the Series A / early B stage when meaningful institutional investment is required to further these initiatives before they truly are growth investment stories: Med Tech and Food Tech, at the local level, are increasingly becoming more relevant and exciting for venture investment. We have developed some expertise in both areas via our successful past investments and have access to people, and key industry contacts that may be helpful. We find these areas somewhat more underserviced by local VCs, and both areas are ripe to benefit from current technological change, including cloud software, data analytics, sensors and innovative devices etc. Locally, through the Ontario hospital system, the University of Toronto, and MaRS, healthcare technologies and companies are beginning to blossom. Our first deal for the new fund in the Med Tech space is a molecular diagnostic company launched by a repeat entrepreneur. Here we are applying some specialized tools developed for photonics companies in the identification of bacteria and fungi in blood at the molecular level. In Food Tech, we will look at things from food replacements to marketplace models, verticalized ICT plays where significant disruption is achieved marrying real-time data, analytics and digital strategies to what is still a relatively “analogue” vertical with lots of “efficiency gain” still to be had. As we would expect, ICT is a large sector in Canada and if you look at some of the recent stats from the CVCA, more start-ups are emerging in the ICT vertical than all others combined, so it cannot be ignored. Here we are looking for companies that build in whitespaces or have a fundamental advantage to disrupt a legacy space with software and data as the core ingredients. We still have a preference for business to business (B2B) and business to business to consumer (B2B2C) opportunities. Through the success of Whitecap I, Whitecap II, and other partner deals, we have developed some great insights and views into areas still very relevant today, like marketplace models where data and analytics are core to the offering (Teranet, Real Matters), Enterprise and Software (PC Docs, Radian 6), Mobility (BNI), Video (iMagicTV), Security (Trust Digital, Third Brigade), and Internet infrastructure (Positron, Loran). Within ICT our preferences are constantly adapting but we currently are interested in themes like, (1) real-time content marketing; (2) data collection, analytics and engagement platforms; (3) machine to machine applications; (4) “Social Science” and enterprise applications; (5) new mobile, social and cloud security and management applications; and, (6) disruptive cloud based financial technology applications. This is just a small sample of potential areas of interest being addressed by a local entrepreneurial talent pool. FinSMEs: Toronto is a fast-growing innovation and tech hubs…do you recommend people to come and work there? Joe: Yes, absolutely but not just to Toronto. I think this is a trend for Canada in general as there has never been more of a level global playing field to successfully start or build a world class Canadian based company. The perception that Canada is just a great R&D base but a market you must leave to successfully build a company, has been radically changing for the better these past several years. A case in point is my own experience several years ago with Radian 6, an Atlantic Canada company that was a transformational pioneer in the social enterprise ultimately being acquired by Salesforce, expanding its presence in Canada. We found many talented people wanting to come back to Canada to work for this exciting company. We are seeing a greater appreciation for the talent pool in Canada and more and more US multinationals are expanding their footprint in Canada as well. Our job as VC’s is to help young companies rise above the noise floor and gain visibility as leaders in their markets; at which point more talent and capital comes to Canada without apprehension.

News Article | June 14, 2010
Site: www.zdnet.com

Security provider Trend Micro has announced it is to acquire Leeds-based cloud storage and data-sync company Humyo for an undisclosed sum. Humyo, which has a secure datacentre in Manchester in an former Bank of England vault, offers data synchronisation and online back-up services for internet-enabled devices. One Humyo service allows customers to back-up PC files when offline, using an external hard-drive attached to the PC. "Humyo's superior data synchronisation technology... is a clear differentiator that helps to ensure that users' files are always safe and secure as well as effortlessly organised," said Trend Micro's chief executive Eva Chen in its announcement on Friday. Trend Micro is not looking to radically change any of Humyo's offerings, the Japan-based security company's solutions architect Rik Ferguson told ZDNet UK. "We've no plans to change the Humyo portfolio, [but] we will incorporate Humyo functionality into our products and product lines," Ferguson said on Monday. He added that Trend Micro is in the process of reviewing how the technology can fit with its products. Previous Trend Micro acquisitions — such as the buyouts of Third Brigade, Provilla and UK-based encryption firm Identum — have incorporated the products while changing the branding, he pointed out. Ferguson said that he was not aware of any plans to shed Humyo staff. A spokesman for the Yorkshire company said it is not worried about job losses. "If anything we're expecting new team members," said the spokesman, who added that the Humyo team currenly had more than 25 staff.

News Article | April 27, 2015
Site: www.techvibes.com

Toronto's Whitecap Venture Partners announced today Whitecap III, the venture capital firm’s third fund and first to bring in investments from limited partners (LPs). In its first close, Whitecap has raised $70 million ($20 million more than its initial $50 million target) towards an ultimate fund size of $80 to $100 million. LPs in the new fund include Kensington Venture Fund, Bank of Montreal (BMO), and several high net-worth families. As a diversified early stage fund focused on industry sectors where Whitecap has built domain knowledge and has demonstrated success, Whitecap III will invest in Information and Communications Technology (ICT), Med Tech and Food Tech sectors. “Having invested in emerging growth companies for more than 20 years, we are pleased to have made a significant difference in fostering innovation in Canada,” says Carey Diamond, Partner, Whitecap III. “In opening the doors to outside investors in our venture fund for the first time, we believe we can now have an even greater impact on driving early-stage company development in key tech sectors thanks to our ability to fund bigger deals and meaningfully participate in follow-on investments. Our LPs believe this too, as they committed 70 percent of our targeted funds within just 90 days, establishing great momentum to launch our next platform.” The Whitecap Venture Partners leadership team brings a wealth of experience to the new fund, and includes Carey Diamond, Blaine Hobson, and Joe Catalfamo. The Fund has assembled an impressive advisory board of exceptional entrepreneurs and business leaders from the formative ventures Whitecap’s partners have previously backed, including Marcel LeBrun, former co-founder and CEO of Radian6; Jason Smith, CEO of Real Matters; Wael Mohamed, COO and director of Trend Micro and former co-founder and CEO of Third Brigade; Bob Courteau, CEO of Altus Group and former president, North America, of SAP AG.

News Article | September 12, 2007
Site: www.techworld.com

Trend Micro will use intrusion prevention software from startup Third Brigade in its own OfficeScan desktop anti-virus software. Trend senior product manager Ron Clarkson said Trend expects to have ready a software plug-in for OfficeScan based on Third Brigade's Deep Security by the fourth quarter of this year. OfficeScan 8.0, the current version of the Trend endpoint-security product, uses a plug-in architecture that facilitates this type of integration, Clarkson says. Customers of OfficeScan 8.0 should be able to simply add the plug-in without a major upgrade. Trend Micro indicated that the arrangement with Third Brigade constitutes the first OEM arrangement it has undertaken for OfficeScan 8.0. Specific pricing and naming for the OfficeScan software plug-in are not yet available.

News Article | April 27, 2015
Site: www.finsmes.com

Toronto, Canada-based Whitecap Venture Partners has held the first close of its third venture capital fund at $70m. LPs in the new fund include Kensington Venture Fund, Bank of Montreal (BMO), and several high net-worth families. Whitecap III, which aims to hold the final close at $80 to $100m, is a diversified early stage (Series A) venture capital fund focused on businesses in Information and Communications Technology (ICT), Med Tech and Food Tech sectors. Advisors of the board include: Marcel LeBrun, former co-founder and CEO of Radian6; Jason Smith, CEO of Real Matters; Wael Mohamed, COO and director of Trend Micro and former co-founder and CEO of Third Brigade; Bob Courteau, CEO of Altus Group and former president, North America, of SAP AG. Led by Carey Diamond, Blaine Hobson, and Joe Catalfamo, Whitecap Venture Partners, Whitecap began as the venture capital arm of Whitecastle Investments Ltd., a family office operating in Toronto.

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