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Qi J.,General Hospital of Shenyang Military Command | Qi J.,Liaoning University of Traditional Chinese Medicine | Li Y.,General Hospital of Shenyang Military Command | Li J.,General Hospital of Shenyang Military Command | And 7 more authors.
Catheterization and Cardiovascular Interventions | Year: 2017

Objective: This study sought to compare the clinical outcomes of 6-month versus 12-month dual antiplatelet therapy (DAPT) in patients receiving multiple biodegradable polymer-coated sirolimus-eluting stents (BP-SES) implants. Background: The clinical outcomes for patients who undergo multiple BP-SES implantation with different DAPT durations are uncertain. Methods: In the I-LOVE-IT 2 trial, 907 patients treated with multiple BP-SES (total stent number ≥2) were assigned to receive 6-month (n = 440) or 12-month (n = 467) DAPT. The primary endpoint was 12-month target lesion failure (TLF), which is a composite of cardiac death, target vessel myocardial infarction (MI) or clinically indicated target lesion revascularization. The major secondary endpoints were 12-month net adverse clinical events, a composite of all causes of death, MI, stroke, any revascularization and bleeding. Results: The number of stents per patient between the 6-month and 12-month DAPT group was similar (2.4 ± 0.7 vs. 2.4 ± 0.7, P = 0.47). The incidence of 12-month TLF was comparable in the 6-month and 12-month DAPT groups (9.3% vs.7.5%, Log-rank P = 0.33). However, landmark analysis showed that 12-month DAPT, compared to 6-month DAPT, was associated with a significantly lower risk of TLF (4.8% vs. 2.4%, Log-rank P = 0.049) at a cost of a slightly increased risk of all bleeding events (0.5% vs. 1.7%, Log-rank P = 0.07) between 6 and 12 months. Conclusions: In patients treated with multiple BP-SES, 6- and 12-month DAPT had similar impacts on 12-month clinical outcomes. Additionally, 12-month DAPT might reduce TLF between 6 and 12 months at the cost of a slightly increased risk of all bleeding events. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.


Zhang H.,Third Affiliated Hospital of Liaoning Medical College | Yu M.,Third Affiliated Hospital of Liaoning Medical College | Guo X.,Third Affiliated Hospital of Liaoning Medical College | Lin Z.,Third Affiliated Hospital of Liaoning Medical College | Chen S.,Third Affiliated Hospital of Liaoning Medical College
Journal of Research in Medical Sciences | Year: 2014

Granulomatous mastitis (GM) is a rare breast disease with unknown etiology. Clinical management strategies for GM include surgery, antibiotics, and steroid treatments. As patients with GM often respond to steroids, GM is thought to be an autoimmune disease. Here we describe a case of trauma‑induced GM that presented as autoimmune disease but was successfully treated by surgery without steroids. The patient showed no sign of recurrence for 11 months. This case provides useful information on both the underlying mechanisms and clinical management of GM. © 2014, Isfahan University of Medical Sciences(IUMS). All rights reserved.


Zhang X.-L.,First Affiliated Hospital of Liaoning Medical College | Zheng S.-L.,First Affiliated Hospital of Liaoning Medical College | Dong F.-R.,First Affiliated Hospital of Liaoning Medical College | Wang Z.-M.,Third Affiliated Hospital of Liaoning Medical College
Journal of International Medical Research | Year: 2012

OBJECTIVE: To study the effect of nimodipine on hippocampal regional cerebral blood flow (rCBF) and proinflammatory cytokines in rats with experimental vascular dementia. METHODS: Male Sprague Dawley rats were randomly divided into four groups (n = 15/group): sham operated controls (group A); focal cerebral ischaemia (group B); vascular dementia (group C); and vascular dementia treated with 20 mg/kg nimodipine daily (group D). The Morris water maze test evaluated learning and memory, and magnetic resonance perfusion-weighted imaging was used to measure rCBF. Hippocampal levels of nuclear factor-κB (NF-κB), tumour necrosis factor-α (TNF-α) and interleukin 1b (IL-1β) were measured. RESULTS: Compared with group C, rats in group D demonstrated significantly improved learning ability and significantly increased hippocampal rCBF. The levels of NF-kB, TNF-α and IL-1β were significantly lower in group D than in group C. Hippocampal nerve cell morphology was abnormal in group C but near normal in group D. CONCLUSIONS: Nimodipine improved the symptoms of cognitive impairment, increased rCBF, reduced hippocampal cytokine levels and alleviated neuronal injury in the hippocampus of rats with experimental vascular dementia. © 2012 Field House Publishing LLP.


Xue L.,Shandong University | Xue L.,Third Affiliated Hospital of Liaoning Medical College | Wu Z.,Third Affiliated Hospital of Liaoning Medical College | Ji X.-P.,Shandong University | And 2 more authors.
Asian Pacific Journal of Tropical Medicine | Year: 2014

Objective: To investigate the effect of salvianolic acid B on rats with myocardial ischemia-reperfusion injury. Methods: SD rats were randomly divided into five groups (n=10 in each group): A sham operation group, B ischemic reperfusion group model group, C low dose salvianolic acid B group, D median dose salvianolic acid B group, E high dose salvianolic acid B group. One hour after establishment of the myocardial ischemia-reperfusion model, the concentration and the apoptotic index of the plasma level of myocardial enzymes (CTn I, CK-MB), SOD, MDA, NO, ET were measured. Heart tissues were obtained and micro-structural changes were observed. Results: Compared the model group, the plasma CTn, CK-MB, MDA and ET contents were significantly increased, NO, T-SOD contents were decreased in the treatment group (group C, D, and E) (P<0.05); compared with group E, the plasma CTn I, CK-MB, MDA and ET levels were increased, the NO, T-SOD levels were decreased in groups C and D (P<0.05). Infarct size was significantly reduced, and the myocardial ultrastructural changes were improved significantly in treatment group. Conclusions: Salvianolic acid B has a significant protective effect on myocardial ischemia-reperfusion injury. It can alleviate oxidative stress, reduce calcium overload, improve endothelial function and so on. © 2014 Hainan Medical College.


Xue L.,Third Affiliated Hospital of Liaoning Medical College | Xue L.,Shandong University | Ozhu X.-H.,Third Affiliated Hospital of Liaoning Medical College | Yang X.-F.,Third Affiliated Hospital of Liaoning Medical College | And 6 more authors.
European Review for Medical and Pharmacological Sciences | Year: 2015

OBJECTIVE: This paper aims to investigate the interaction mechanism between pioglitazone/ simvastatin and the CD40-CD40 ligand (CD40-CD40L) system and to determine their interaction effects on atherosclerosis in rabbits. MATERIALS AND METHODS: Forty rabbits were randomly divided into five groups of eight: normal control, hyperlipidemia model, pioglitazone, simvastatin, and pioglitazone combined with simvastatin therapy. The rabbits were raised for 16 weeks. Blood samples and the aortic length were taken after 16 weeks with the following indicators: (1) blood lipid measurement [total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C)] were measured; (2) measurement of serum high-sensitivity C-reactive protein (hsCRP), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 (sICAM-1), soluble CD40 ligand (sCD40L), and matrix metallopeptidase-9 (MMP-9) by enzyme-linked immunosorbent assay; (3) aortic pathological observation and measurement of the area ratios for plaque/intimal; and (4) expression determination of CD40L in plaque parts by immunohistochemistry. RESULTS: In the treatment groups, the levels of TC, TG, LDL-C, hsCRP, sVCAM-1, sICAM-1, sCD40L, and MMP-9 increased, and HDL-C level, plaque/intimal area ratio, and CD40 expression in the plaque parts decreased. Improved effects were also found in the combination treatment group. CONCLUSIONS: Pioglitazone and simvastatin may inhibit different functions, such as inflammatory response and lipid regulation, by inhibiting the CD40-CD40L signaling pathway to suppress the formation of atherosclerosis. Therefore, the combined application of pioglitazone and simvastatin has synergistic effects.


Zhang Y.,Third Affiliated Hospital of Liaoning Medical College | Liu L.,First Affiliated Hospital of Liaoning Medical College | Li C.,First Affiliated Hospital of Liaoning Medical College | Ai H.,Third Affiliated Hospital of Liaoning Medical College
Cancer Biomarkers | Year: 2014

BACKGROUND: The expressions of leptin and its receptor (ObR) have been observed in human endometrial cancer (EC) cells, and leptin can promote the proliferation of EC cells. However, the correlation between leptin and ObR expressions in EC and the clinicopathology of EC is still unclear. OBJECTIVE: This study investigated the correlation between the expressions of leptin and ObR in EC and the clinicopathology of EC. METHODS: Immunohistochemistry was used in this study. The correlation between the expressions of leptin and ObR in EC and the clinicopathology of EC was analyzed. RESULTS: In the EC specimens, the expressions of leptin and ObR were positively correlated with the invasiveness of the cancer and the obesity of patients, but inversely correlated with histological grade. The percentages of leptin and ObR were significantly higher in the patients with lymph node metastasis. Positive expression of leptin and ObR was associated with poorer prognosis (3-year survival rate). Moreover, the expression of leptin and ObR was associated with positive expression of estrogen receptor. CONCLUSIONS: Leptin and ObR are overexpressed in EC, and their expressions are associated with malignancy, invasion, and metastasis of EC. Thus, leptin and ObR may be important indicators in EC. © 2014 - IOS Press and the authors. All rights reserved.


PubMed | Sun Yat Sen University and Third Affiliated Hospital of Liaoning Medical College
Type: Journal Article | Journal: Chinese medical journal | Year: 2014

Glaucoma secondary to systemic lupus erythematosus (SLE) is an uncommon but serious complication that threatens vision and therefore cannot be neglected. A few cases of secondary glaucoma resulting from lupus-induced or iatrogenic ocular impairments have been reported in association with SLE. However, a systematic analysis of the diagnosis and treatment of glaucoma secondary to SLE has not been reported in the literature. The aim of this study is to further investigate the relationship between glaucoma and SLE.In this study, we reviewed nine eyes of five patients diagnosed with secondary glaucoma associated with SLE, including one case of neovascular glaucoma and four cases of steroid-induced glaucoma.Neovascular glaucoma was successfully treated by Ahmed glaucoma valve implantation surgery with adjunctive ranibizumab intravitreal injection, followed by panretinal photocoagulation (PRP). The steroid-induced glaucoma in eight eyes of four cases were controlled by trabeculectomy along with antiproliferative agents.Regular follow-up ocular examinations should be conducted to ensure early diagnosis and treatment of secondary glaucoma in SLE patients to improve the prognosis of vision.


PubMed | Panjin Central Hospital, First Affiliated Hospital of Liaoning Medical College and Third Affiliated Hospital of Liaoning Medical College
Type: Journal Article | Journal: Cancer biomarkers : section A of Disease markers | Year: 2014

The expressions of leptin and its receptor (ObR) have been observed in human endometrial cancer (EC) cells, and leptin can promote the proliferation of EC cells. However, the correlation between leptin and ObR expressions in EC and the clinicopathology of EC is still unclear.This study investigated the correlation between the expressions of leptin and ObR in EC and the clinicopathology of EC.Immunohistochemistry was used in this study. The correlation between the expressions of leptin and ObR in EC and the clinicopathology of EC was analyzed.In the EC specimens, the expressions of leptin and ObR were positively correlated with the invasiveness of the cancer and the obesity of patients, but inversely correlated with histological grade. The percentages of leptin and ObR were significantly higher in the patients with lymph node metastasis. Positive expression of leptin and ObR was associated with poorer prognosis (3-year survival rate). Moreover, the expression of leptin and ObR was associated with positive expression of estrogen receptor.Leptin and ObR are overexpressed in EC, and their expressions are associated with malignancy, invasion, and metastasis of EC. Thus, leptin and ObR may be important indicators in EC.


PubMed | Shandong University and Third Affiliated Hospital of Liaoning Medical College
Type: Journal Article | Journal: Asian Pacific journal of tropical medicine | Year: 2014

To investigate the effect of salvianolic acid B on rats with myocardial ischemia-reperfusion injury.SD rats were randomly divided into five groups (n=10 in each group): A sham operation group, B ischemic reperfusion group model group, C low dose salvianolic acid B group, D median dose salvianolic acid B group, E high dose salvianolic acid B group. One hour after establishment of the myocardial ischemia-reperfusion model, the concentration and the apoptotic index of the plasma level of myocardial enzymes (CTn I, CK-MB), SOD, MDA, NO, ET were measured. Heart tissues were obtained and micro-structural changes were observed.Compared the model group, the plasma CTn, CK-MB, MDA and ET contents were significantly increased, NO, T-SOD contents were decreased in the treatment group (group C, D, and E) (P<0.05); compared with group E, the plasma CTn I, CK-MB, MDA and ET levels were increased, the NO, T-SOD levels were decreased in groups C and D (P<0.05). Infarct size was significantly reduced, and the myocardial ultrastructural changes were improved significantly in treatment group.Salvianolic acid B has a significant protective effect on myocardial ischemia-reperfusion injury. It can alleviate oxidative stress, reduce calcium overload, improve endothelial function and so on.


PubMed | Third Affiliated Hospital of Liaoning Medical College
Type: Journal Article | Journal: Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences | Year: 2015

Granulomatous mastitis (GM) is a rare breast disease with unknown etiology. Clinical management strategies for GM include surgery, antibiotics, and steroid treatments. As patients with GM often respond to steroids, GM is thought to be an autoimmune disease. Here we describe a case of trauma-induced GM that presented as autoimmune disease but was successfully treated by surgery without steroids. The patient showed no sign of recurrence for 11 months. This case provides useful information on both the underlying mechanisms and clinical management of GM.

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