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News Article | May 9, 2017
Site: www.prnewswire.com

Another research by Global Market Insights indicates that strong R&D spending trends for synthetic biology to enable drug and vaccine development, including Europe NEST program will stimulate growth. Organizations including DBT (Department of Biotechnology) and NTBT (National Biotechnology Board) provides funding for promoting biotechnology market share. The U.S. biotechnology market size held a dominant position in terms of industry revenue share, with Europe following. This trend is likely to continue throughout the forecast period. The U.S. will further see increased adoption of products based on these platforms, as growth for personalized medicine becomes a preference. Quest PharmaTech Inc. (TSX-V: QPT) is a pharmaceutical company developing and commercializing products to improve the quality of life. Just this morning the company announced that its subsidiary, OncoQuest Inc. ("OncoQuest"), a biopharmaceutical company focused on the development and commercialization of immunotherapeutic products for the treatment of cancer has completed the enrollment of the first patient in a Phase 1/2 clinical study to evaluate the use of oregovomab in combination with Nivolumab, an anti-PD1 human monoclonal antibody which works as a checkpoint inhibitor in ovarian cancer patients in the recurrent setting. This clinical trial is being conducted at the National Cancer Centre in Singapore ("NCCS"), with Dr. Tira Tan as Principal Investigator, Adjunct Associate Professor John Chia from Oncocare Cancer Centre as the Study Chair, and Dr. Jack Chan as the co-chair. "We are extremely excited about launching this study," noted Dr. John Chia. "Ovarian cancer is a lethal disease, and this trial may offer new hope for our patients. Early clinical data suggests that oregovomab may improve the immune system's processing of cancer antigens, and enhance the immune ability to recognize these cancer targets. We believe that the combination of oregovomab and Nivolumab, which amplifies such immune activity, will have a synergistic effect to elicit a higher quality tumor immune response, and hence improve control of the cancer." This will be the first clinical trial testing the combination of oregovomab with a checkpoint inhibitor as potential treatment of ovarian cancer in the recurrent setting. "We continue to explore the potential of oregovomab in various stages of the progression of ovarian cancer," said Dr. Madiyalakan, CEO of Quest and OncoQuest. In frontline ovarian cancer, OncoQuest has recently announced positive interim results from its randomized controlled multi-center Phase 2 clinical trial with oregovomab as an indirect immunizer, in scheduled combination with carboplatin and paclitaxel. "In the recurrent setting, we are exploring the use of oregovomab with immune adjuvants in two clinical trials. The trial NCCS is conducting is in combination with a checkpoint inhibitor. We are also in the process of initiating a trial in U.S. in combination with a TLR3 agonist, Hiltonol®," continued Dr. Madiyalakan. Theratechnologies Inc. (OTC: THERF) is a specialty pharmaceutical company addressing unmet medical needs to promote healthy living and an improved quality of life among HIV patients. Recently, the company announced that its partner, TaiMed Biologics, Inc., has completed the submission of a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for ibalizumab for the treatment of multidrug resistant Human Immunodeficiency Virus-1 (MDR HIV-1). If approved, ibalizumab will be the first antiretroviral treatment (ART) with a new mechanism of action to be introduced in nearly 10 years and the only treatment that does not require daily dosing. CRH Medical Corporation (NYSE: CRHM) is a North American company focused on providing gastroenterologists throughout the United States with innovative services and products for the treatment of gastrointestinal diseases. On March 15, 2017, the company announced that it has completed an accretive transaction whereby CRH has acquired a 60% interest in a gastroenterology ("GI") anesthesia practice in Kissimmee Florida ("Kissimmee"). CRH also announces that it has entered into an exclusive agreement to develop and manage a monitored anesthesia care ("MAC", or "Deep Sedation") program with Puget Sound Gastroenterology ("PSG"), located in Washington State. Aurinia Pharmaceuticals Inc. (NASDAQ: AUPH) a clinical stage biopharmaceutical company focused on the global immunology market, today announced additional 48-week results from its global Phase IIb AURA-LV (AURA) study in lupus nephritis (LN) during the National Kidney Foundation 2017 Spring Clinical Meetings in Orlando, FL. In addition to the trial meeting its complete and partial remission ("CR"/"PR") endpoints at 48 weeks, all pre-specified secondary endpoints that have been analyzed to date were also met at 48 weeks. These pre-specified endpoints include: time to CR and PR (speed of remission); reduction in Systemic Lupus Erythematosus Disease Activity Index or SLEDAI score; and reduction in urine protein creatinine ratio (UPCR) over the 48-week treatment period. The data were presented during the late-breaking session by lead author Dr. Samir Parikh, a clinical investigator for the study and Assistant Professor of Clinical Nephrology at the Ohio State University. Concordia International Corp. (NASDAQ: CXRX) together with its subsidiaries is an international specialty pharmaceutical company focused on generic and legacy pharmaceutical products and orphan drugs. On January 3rd, the company announced it has entered into a three-year, co-promotion agreement with RedHill Biopharma Ltd. through which the companies expect to expand sales of Donnatal®, Concordia's product used in the treatment of irritable bowel syndrome. Concordia's North America segment seeks to acquire and manage drugs that are in the maturity or legacy stage of the pharmaceutical product lifecycle and continue on a predictable revenue generation path. These products have a well-established record of safety and efficacy and a history of stable demand. Please Sign Up Now at http://www.FinancialBuzz.com to receive alerts on Trending Financial News from all these companies. "The Latest Buzz in Financial News" Subscribe Now! 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Financialbuzz.com has not been compensated directly by any of the companies mentioned here in this editorial. We are not an independent news media provider and therefore do not represent or warrant that the information posted on the Site is accurate, unbiased or complete. FinancialBuzz.com receives fees for producing and presenting high quality and sophisticated content on FinancialBuzz.com along with other financial news PR media services. FinancialBuzz.com does not offer any personal opinions or bias commentary as we purely incorporate public market information along with financial and corporate news. FinancialBuzz.com only aggregates or regurgitates financial or corporate news through our unique financial newswire and media platform. For this release, FinancialBuzz.com has been compensated four thousand dollars for financial news dissemination and PR services by a third party non affiliate for Quest PharmaTech Inc. 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News Article | May 16, 2017
Site: www.marketwired.com

MONTRÉAL, QUÉBEC--(Marketwired - 16 mai 2017) - Theratechnologies inc. (TSX:TH) a tenu aujourd'hui son assemblée annuelle des actionnaires. Au cours de l'assemblée, les actionnaires ont élu les membres du conseil d'administration pour un mandat d'un an et nommé KPMG s.r.l., à titre d'auditeurs de la Société pour l'année financière en cours. De plus, les actionnaires ont adopté une résolution modifiant le régime d'options d'achat d'actions de la Compagnie pour permettre aux membres du Conseil d'adopter certains amendements au régime sans avoir à obtenir l'approbation des actionnaires. Tous les candidats proposés pour siéger au conseil d'administration ont été élus dans les proportions suivantes : En plus de passer en revue les faits saillants de la dernière année, Mme Svoronos et M. Luc Tanguay, respectivement présidente du Conseil et président et chef de la direction de Theratechnologies, ont partagé leur vision quant à la direction que prendra la Société au cours des prochaines années. « Depuis que nous avons repris les droits de commercialisation d'EGRIFTAMD, l'avenir n'a jamais semblé aussi prometteur pour Theratechnologies. Nous avons rapidement été en mesure de constater à quel point nous pouvions bénéficier d'un effet de levier. Avec le lancement potentiel de l'ibalizumab aux États-Unis, nous sommes maintenant mieux positionnés que jamais pour atteindre de nouveaux sommets de croissance et donner à notre Compagnie encore plus de momentum, » a déclaré Luc Tanguay, président et chef de la direction, Theratechnologies inc. « De plus, nous sommes très enthousiasmés par l'acquisition des droits commerciaux de l'ibalizumab pour l'Europe. Nous avons conclu une remarquable entente avec notre partenaire, TaiMed, pour ce territoire. S'il est approuvé en Europe, l'ibalizumab appuiera davantage notre croissance à moyen et long termes pour le bénéfice de notre Compagnie et de nos actionnaires, » a ajouté M. Tanguay. « Le Conseil est très satisfait de la façon dont le plan stratégique de la direction se réalise. Je suis très fière de ce que nous avons accompli jusqu'à présent et je suis convaincue que le meilleur est à venir, » a déclaré Dawn Svoronos, présidente du conseil de Theratechnologies. « Néanmoins, je suis plus que déçue de la décision prise par le gouvernement du Québec de refuser le remboursement d'EGRIFTAMD, principalement en raison des patients au Québec qui en ont besoin. Je souhaiterais que l'appareil étatique ait suffisamment de vision pour reconnaître ce qu'une compagnie établie au Québec a accompli et envoie ainsi le message qu'il appuie la recherche faite au Québec, » a ajouté Dawn Svoronos. Theratechnologies (TSX:TH) est une société pharmaceutique spécialisée dans le traitement de besoins médicaux non satisfaits en vue de promouvoir auprès des patients infectés par le VIH un mode de vie sain et une qualité de vie améliorée. D'autres renseignements sur Theratechnologies sont disponibles sur le site Web de la Société au www.theratech.com et sur SEDAR au www.sedar.com. Le présent communiqué de presse renferme des énoncés qui sont considérés des informations prospectives au sens de la législation en valeurs mobilières qui reposent sur les opinions et les hypothèses de la direction et sur l'information dont celle-ci dispose présentement. Vous pouvez identifier les énoncés prospectifs par l'emploi de mots tels que « peut », « va », « pourrait », « voudrait », « devrait », « perspectives », « croit », « planifie », « envisage », « prévoit », « s'attend » et « estime » ou la forme négative de ces termes ou des variations de ceux-ci. Les énoncés prospectifs présents dans ce communiqué de presse incluent, notamment, l'approbation de l'ibalizumab aux États-Unis et en Europe pour le traitement des patients atteints d'une infection au VIH-1 PRM et la croissance de Theratechnologies basée sur ces approbations. Les énoncés prospectifs sont fondés sur un certain nombre d'hypothèses et sont sujets à des risques et incertitudes dont plusieurs sont hors de la volonté de Theratechnologies et pourraient entrainer un écart marqué entre les résultats réellement obtenus et ceux exprimés, expressément ou implicitement, par de tels énoncés prospectifs. Ces hypothèses incluent, notamment, que la soumission du BLA sera acceptée aux fins d'évaluation par la FDA, que toutes les données obtenues lors des études cliniques de Phases I, II et III seront suffisantes pour démontrer l'efficacité et l'innocuité de l'ibalizumab et que d'autres essais cliniques ne seront pas requis, que l'ibalizumab sera approuvé par la FDA et les autorités réglementaires européennes en tant que traitement pour l'infection au VIH-1 PRM et que, si l'ibalizumab est approuvé, Theratechnologies aura, en temps opportun, mis en place l'infrastructure requise pour le lancement et la commercialisation de l'ibalizumab aux États-Unis et en Europe. Les risques et incertitudes incluent, notamment, le risque que les données obtenues jusqu'à présent des études de Phases I, II et III ne permettent pas à la FDA ou à un organisme réglementaire européen d'approuver l'ibalizumab, que d'autres études doivent être complétées avant que la FDA ou un organisme réglementaire européen approuve l'ibalizumab, que la FDA et/ou un organisme réglementaire européen n'approuve pas l'ibalizumab en tant que traitement pour l'infection au VIH-1 PRM ou que, si approuvé, la FDA et/ou un organisme réglementaire européen imposent des restrictions importantes à son utilisation restreignant ainsi la population de patients pouvant avoir accès à ce produit. Les investisseurs éventuels sont priés de se reporter à la rubrique « Facteurs de risque » de la notice annuelle de la société datée du 7 février 2017 pour plus d'informations sur les risques et incertitudes touchant Theratechnologies. La notice annuelle peut être consultée sur le site web de la Compagnie à l'adresse www.theratech.com ou sur le site web SEDAR à l'adresse www.sedar.com. Le lecteur est prié d'examiner ces risques et incertitudes attentivement et de ne pas se fier indûment aux énoncés prospectifs. Les énoncés prospectifs reflètent les attentes actuelles concernant des événements futurs. Ils ne sont valables qu'à la date du présent communiqué de presse et traduisent nos attentes à cette date. Nous ne nous engageons aucunement à mettre à jour ou à réviser l'information contenue dans ce communiqué de presse, que ce soit à la suite de l'obtention de nouveaux renseignements, à la suite de nouveaux événements ou circonstances ou pour toute autre raison que ce soit, sauf si les lois en vigueur l'exigent.


The invention relates to compositions which are useful for inhibiting prostaglandin F_(2&agr); receptor. The compositions include, but are not limited to, linear peptides, peptide analogs, and peptidomimetics. Methods of using the compositions of the invention to treat preterm labor and dysmenorrhea are disclosed.


Patent
Theratechnologies | Date: 2012-01-11

Improved methods for determining normal IGF-1 levels in HIV infected subjects, based on a determination of the log of IGF-1 values obtained in blood-derived samples from a population of HIV-infected subjects, are disclosed. Also disclosed are methods of determining whether a given HIV-infected subject exhibits a normal IGF-1 level, based on a comparison of either the IGF-1 value or the log of the IGF-1 value obtained from a blood-derived sample of the subject with a normative IGF-1 range determined using the exponentiation of the log of IGF-1 values or the log of IGF-values obtained in blood-derived samples from a population of age- and gender-matched HIV-infected subjects. Such methods are useful for example to monitor GH stimulation therapy in HIV-infected subjects.


Patent
Theratechnologies | Date: 2011-11-02

There is provided a GRF compound or analog thereof for use in improving daytime vigilance and/or cognitive function in a subject.


Patent
Theratechnologies | Date: 2011-01-11

The invention relates to use of a GH secretagogue (e.g. GRF or an analog thereof) for increasing muscle function in a subject. Also disclosed herein are corresponding methods, packages and compositions.


Stabilized solid and liquid pharmaceutical formulations comprising a GRF molecule as active ingredient, such as GRF analogs including those comprising an N-terminal-attached hydrophobic moiety, such as [trans-3-hexenoyl]hGHRH (1-44) amide, are disclosed. The formulation comprises a GRF molecule or a pharmaceutically acceptable salt thereof and a -cyclodextrin which is not conjugated to the GRF molecule or salt thereof. Also disclosed is the use of the formulation for the treatment of various conditions, methods of preparing the formulation, as well as kits containing it. Methods of stabilizing (e.g., with respect to chemical stability) such GRF molecules, as well as methods of inhibiting their deamidation at Asn^(8), are also disclosed.


Patent
Theratechnologies | Date: 2011-07-07

The invention relates to use of a GH secretagogue (e.g. GRF or an analog thereof) for (1) altering a lipid parameter in a subject; (2) altering a body composition parameter in a subject, (3) treating a condition characterized by deficient or decreased bone formation in a subject (4) improving daytime vigilance and/or cognitive function in a subject, (5) improving a metabolic condition in a subject, (6) improving anabolism in a catabolic condition in a subject, and/or (7) improving and/or reconstituting immune function in a subject.


Patent
Theratechnologies | Date: 2012-04-17

Novel GRF analogs having GRF activity are described herein, as well as uses thereof for example as a GRF receptor agonist, e.g., to induce growth hormone secretion in a subject or biological system.


Patent
Theratechnologies | Date: 2012-10-18

Peptide compounds derived from human melanotransferrin, and compositions thereof, are described. Uses of these peptide compounds, for example to modulate angiogenesis and/or cell migration, and/or to treat angiogenesis-related disorders (e.g., cancer), are also described.

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