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Patent
Theranos | Date: 2017-03-15

Methods and systems are provided for connecting an electronic device (405) to a network. In some situations, the electronic device (405) connects to a first network provider (410) and pings a first server (420) having a static internet protocol address and a second server (425) having a dedicated uniform resource locator. If the electronic device (405) receives a response from the first (420) and second server (425), the electronic device maintains its connection to the first network provider (410). Otherwise, the electronic device (405) connects to a second network provider (415) and pings the first (420) and second servers (425).


The devices, systems, and methods disclosed herein provide sample verification capabilities in a single device or system. Devices are disclosed herein. Systems including these devices are also provided. These devices and systems may be configured for verifying sample integrity prior to a subject leaving a sample collection site so that any further samples or other corrective action can occur without having to make a separate visit.


Patent
Theranos | Date: 2016-10-11

Bodily fluid sample collection systems, devices, and method are provided. The sample is collected at a first location and subjected to a first sample processing step. The sample may be shipped to a second location and subjected to a second sample processing step that does not introduce contaminants into a plasma portion of the sample formed from the first processing step. The sample may also be mixed with other material(s) in the collection device.


Methods and devices are provided for sample collection and sample separation. In one embodiment, a device is provided for use with a formed component liquid sample, the device comprising at least one sample inlet for receiving said sample; at least a first outlet for outputting only a liquid portion of the formed component liquid sample; at least a second outlet for outputting the formed component liquid sample at least a first material mixed therein.


Patent
Theranos | Date: 2016-11-03

Improved methods, devices, and systems for mixing fluids, including small volumes of fluid, are provided. Pressing a pipette tip against an inner surface of a mixing vessel allows pressure to be applied within the tip. Greater pressure may be built-up than would be possible without engaging the tip with the mixing vessel. Disengaging the tip allows fluid flow through the tip, providing improved fluid mixing as compared to methods lacking engagement of a pipette tip with an inner surface of a mixing vessel while applying pressure within the pipette tip. Mixing vessels having features on an inner surface that are configured to engage a pipette tip, and to occlude an orifice of a pipette tip, are provided. Sample analysis devices and systems including pipette tips and mixing vessels configured to engage each other for pressure application within the tip are provided.


Patent
Theranos | Date: 2016-11-01

Methods, devices, systems, and apparatuses are provided for the image analysis of measurement of biological samples.


Patent
Theranos | Date: 2017-06-21

The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.


Patent
Theranos | Date: 2016-11-21

Systems, methods, and devices for detecting infections in a clinical sample are provided. Small-volume clinical samples obtained at a point-of-service (POS) location and may be tested at the POS location for multiple markers for multiple diseases, including upper and lower respiratory diseases. Samples may be tested for cytokines, or for inflammation indicators. Dilution of samples, or levels of detection, may be determined by the condition or past history of a subject. Test results may be obtained within a short amount of time after sample placement in a testing device, or within a short amount of time after being obtained from the subject. A prescription for treatment of a detected disorder may be provided, and may be filled, at the POS location. A bill may be automatically generated for the testing, or for the prescription, may be automatically sent to an insurance provider, and payment may be automatically obtained.


Reagents, assays, methods, kits, devices, and systems for rapid measurement of cholesterol and cholesterol sub-fractions from a blood sample are provided. Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol can be measured in a single assay using kinetic measurements, under conditions in which cholesterol sub-species are converted to a detectable product at distinct rates. The detectable product is measured at different times after assay initiation. A lipase, cholesterol esterase, cholesterol oxidase and a peroxidase may be used together to produce colored product in amounts directly proportional to the quantity of cholesterol converted. Methods for calculating very-low density lipoprotein cholesterol levels by further including triglyceride measurements are disclosed. Assays may be performed in a single reaction mixture, allowing more accurate and precise cholesterol determinations, including ratios of cholesterol sub-fractions to total cholesterol, at less expense, than would be expected by performing several different assays in different reaction mixtures.


Patent
Theranos | Date: 2017-07-12

Systems and methods for determining pathogens and antimicrobial resistance of pathogens in a sample are provided.

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