France, ID, United States
France, ID, United States

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An image-guided therapeutic apparatus (1) comprises- a treatment device (2), preferably a HIFU transducer, for treating tissue,- at least one imaging device (3) for guidance of a treatment,- means for providing an image (4),- a display (5) for displaying an image and- planning means (6) for planning a treatment. The planning means (6) is adapted to create a lesion representation (9) of a lesion that will be created in tissue on the image (7) and to overlay said lesion representation (9) over said image (7). The size and/or shape and/or position of the lesion representation (9) is changeable, in particular in dependence on the characteristics of the tissue.


The invention relates to a device for treatment of a tissue (8) of a living being, including a transducer (4) for emitting a beam of ultrasound waves mounted on a movable treatment head (1), an ultrasonic imaging device (2, 3), optionally an inflatable balloon (5) surrounding the treatment head (1) and containing a coupling fluid, and a control unit for controlling the movement of the treatment head (1) and the operation of the transducer (4) and the imaging device (2, 3), wherein the treatment head (1) is adjustable to at least two of a treatment position (T), a monitoring position (M) and a travel position (S) in order to avoid displacement of tissues (7, 8) during displacement of the treatment head (1) an increase imaging quality.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-IEF | Phase: FP7-PEOPLE-2013-IEF | Award Amount: 202.41K | Year: 2015

Focused Ultrasound Surgery (FUS) is an emerging, non-invasive modality, which involves the extracorporeal administration of High Intensity Focused Ultrasound (HIFU), a non-ionising form of radiation, to ablate via frictional effects diseased tissue in a specific target area. Although clinically effective the process is inherently inefficient, which has so far limited its wide spread use in medicine. The demonstration of a clinically applicable method for increasing the rate of energy absorption at the target region would herald a breakthrough for this technology. The proposed technique is cavitation mediated enhanced heating. The rationale here is that bubble activity at the ultrasound focus can lead to substantially higher rates of tissue heating. Cavitation refers to the formation of pockets of gas in the tissue exposed to HIFU. Unfortunately with the typical frequencies and intensities used, cavitation activity is known to rapidly evolve and cause risk of serious collateral damage to the surrounding healthy tissue. However, if cavitation can be monitored and controlled efficiently, faster treatment times can be achieved without negative side effects. The objective of the CavAblate project is to integrate new cavitation characterization detection and control techniques, with sono-elastographic capabilities for the next generation of cavitation mediated enhanced FUS ablation.


A method of operating a device (1) for treatment of a tissue (6) of a living being and such a device (1) including a transducer (2) comprising at least two subtransducers (2, 2), each for emitting a sub-beam (8) of ultrasound waves, preferably high intensity focused ultrasound waves, for irradiating the tissue (6). Each of the sub-beams (8) is focused on or focusable onto a focal point (F). In order to reduce skin burns, the intersection Area (A_(si)) of a skin surface (7) for each sub-beam (8) is evaluated and a power (P_(si)) and/or a duration (t_(si)) of the irradiation, for every sub-transducer (2, 2), is determined as a rate of the total power (P_(total)) or duration (t_(total)) depending from the evaluated intersection area (A_(si)).


A device for treatment of a tissue (8) of a living being, including a transducer (4) for emitting a beam of ultrasound waves mounted on a movable treatment head (1), an ultrasonic imaging device (2, 3), optionally an inflatable balloon (5) surrounding the treatment head (1) and containing a coupling fluid, and a control unit for controlling movement of the treatment head (1) and operation of the transducer (4) and the imaging device (2, 3). In order to avoid displacement of tissues (7, 8) during displacement of the treatment head (1) and increase imaging quality, the treatment head (1) is adjustable to at least two of a treatment position (T), a monitoring position (M) and a travel position (S).


The invention relates to a method for operating a device (1) for treatment of a tissue (6) of a living being and such a device (1) including a transducer (2) comprising at least two sub-transducers (2, 2), each for emitting a sub-beam (8) of ultrasound waves, preferably high intensity focused ultrasound waves, for irradiating the tissue (6), each of the sub-beams (8) being focused on or focusable onto a focal point (F). In order to reduce skin burns, the intersection Area (A_(si)) of a skin surface (7) with each sub-beam (8) is evaluated and a power (P_(si)) and/or duration (t_(si)) of the irradiation for every sub-transducer (2 , 2) as a rate of the total power (P_(total)) respectively duration (t_(total)) depending from the evaluated intersection area (A_(si)) is determined.


Patent
Theraclion | Date: 2016-01-06

A device (1) for therapeutic treatment comprising the following components:A HIFU transducer (2) operable in at least a probing mode during a probing phase and in a treatment mode during a treatment phase; a detector (6) designed to detect a change of tissue properties caused by said HIFU pulses (3) in the target (4) during said probing phase; calculating means (7) such as a computer or a microprocessor for determining at least one probing parameter necessary to achieve said change of tissue properties detected by the detector (6) during the probing phase a control (8) for defining said treatment parameters on the basis of said probing parameters is provided; the control (8) being designed to change the operation characteristics from the probing phase to the treatment phase by increasing an area on the target (4) of at least one pulse (3) impinged by said HIFU pulse (3) during the treatment phase.


Patent
Theraclion | Date: 2013-03-20

The present invention relates to a medical support (1) for a body part (2) comprising at least one envelope with an outer wall (3) defining a cavity (4) within said envelope. The outer wall (4) includes at least one contact area (8) to receive a body part from a patient. This at least one contact area (8) is made of a flexible material having an acoustic impedance of from 1.410^(6) Pasm^(-1) to 1.710^(6) Pasm^(-1), preferably of 1.5610^(6) Pasm^(-1).


An image-guided therapeutic apparatus (1) comprises a treatment device (2), preferably a HIFU transducer, for treating tissue, at least one imaging device (3) for guidance of a treatment, a mechanism for providing an image (4), a display (5) for displaying an image and planning mechanism (6) for planning a treatment. The planning mechanism (6) is adapted to create a lesion representation (9) of a lesion that will be created in tissue on the image (7) and to overlay the lesion representation (9) over the image (7). The size and/or shape and/or position of the lesion representation (9) is changeable, in particular, depending on the characteristics of the tissue.


Patent
Theraclion | Date: 2015-12-28

A coupling liquid for ultrasound devices, preferably high intensity focused ultrasound (HIFU). The coupling liquid comprises a liquid aqueous solution of at least one hydrophilic polymer having an average molecular mass of between 30,000 and 70,000 and at least one alcohol with a carbon chain of 1 to 7 carbon atoms. Also disclosed is a container (10) for an ultrasound coupling liquid having a thin wall.

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