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France, ID, United States

Theraclion | Date: 2010-12-07

The invention concerns a device for treatment of an organ or tissue of a living being. The device comprises at least one treatment transducer for emission of ultrasound waves, preferably high intensity focused ultrasound (HIFU) waves, focusable on a focal point within or on the surface of said organ or tissue, as well as means for rotating said treatment transducer around an axis which intersects said focal point. The device further comprises synchronization means for synchronizing the rotation of the treatment transducer with at least the emission of ultrasound waves from said treatment transducer and/or an additional imaging transducer.

Agency: Cordis | Branch: FP7 | Program: MC-IEF | Phase: FP7-PEOPLE-2013-IEF | Award Amount: 202.41K | Year: 2015

Focused Ultrasound Surgery (FUS) is an emerging, non-invasive modality, which involves the extracorporeal administration of High Intensity Focused Ultrasound (HIFU), a non-ionising form of radiation, to ablate via frictional effects diseased tissue in a specific target area. Although clinically effective the process is inherently inefficient, which has so far limited its wide spread use in medicine. The demonstration of a clinically applicable method for increasing the rate of energy absorption at the target region would herald a breakthrough for this technology. The proposed technique is cavitation mediated enhanced heating. The rationale here is that bubble activity at the ultrasound focus can lead to substantially higher rates of tissue heating. Cavitation refers to the formation of pockets of gas in the tissue exposed to HIFU. Unfortunately with the typical frequencies and intensities used, cavitation activity is known to rapidly evolve and cause risk of serious collateral damage to the surrounding healthy tissue. However, if cavitation can be monitored and controlled efficiently, faster treatment times can be achieved without negative side effects. The objective of the CavAblate project is to integrate new cavitation characterization detection and control techniques, with sono-elastographic capabilities for the next generation of cavitation mediated enhanced FUS ablation.

Theraclion | Date: 2011-05-16

This invention relates to a coupling liquid for ultrasound devices, preferably high intensity focused ultrasound (HIFU). The coupling liquid comprises a liquid aqueous solution of at least one hydrophilic polymer having an average molecular mass of between 30,000 and 70,000 and at least one alcohol with a carbon chain of 1 to 7 carbon atoms. Also disclosed is a container (

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