Theagenio Hospital

Thessaloníki, Greece

Theagenio Hospital

Thessaloníki, Greece

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Kosmidis P.A.,Hygeia Hospital | Fountzilas G.,Aristotle University of Thessaloniki | Eleftheraki A.G.,Hellenic Cooperative Oncology Group Data Office | Kalofonos H.P.,University of Patras | And 11 more authors.
Annals of Oncology | Year: 2011

Background: Paclitaxel (Taxol) and vinorelbine have shown synergism of cytotoxic effects in vitro and clinical activity in phase I and II studies. This combination was compared prospectively with the paclitaxel/gemcitabine regimen in non-operable non-small-cell lung cancer. Patients and methods: Chemotherapy-naive patients, stage IIIbwet and IV with performance status (0-1), were randomized to receive paclitaxel 200 mg/m2 on day 1 plus gemcitabine 1 gm/m2 (group A) on days 1 and 8 every 3 weeks or paclitaxel 80 mg/m2 plus vinorelbine 22.5 mg/m2 (group B) on days 1, 8 and 15 every 4 weeks. Results: A total of 398 out of 415 patients were eligible for analysis on intent-to-treat basis (group A: 196, group B: 202). Progression-free survival (PFS) was 5.0 months [95% confidence interval (CI) 4.3-5.6] and 4.4 months (95% CI 3.7-5.2) for groups A and B respectively (P = 0.365). Median survival was 11.1 months (95% CI 9.2-13.0) and 8.6 months (95% CI 7.0-10.2) for groups A and B respectively (P = 0.147). Grade 3/4 neutropenia and leukopenia were worse in group B (P < 0.001, in both cases). Febrile neutropenia and severe infections were more prominent (P < 0.001, P = 0.029 respectively) in group B. Conclusion: Although response rate, PFS and survival were non-different in both groups, toxicity was significantly worse in group B and therefore further investigation of P-Vin is of no value. © The Author 2010. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.


Kaltsas G.,National and Kapodistrian University of Athens | Chrisoulidou A.,Theagenio Hospital | Piaditis G.,George Genimatas Hospital | Kassi E.,National and Kapodistrian University of Athens | Chrousos G.,National and Kapodistrian University of Athens
Trends in Endocrinology and Metabolism | Year: 2012

Adrenal incidentalomas (AI) are serendipitously discovered lesions during abdominal imaging studies that need to be investigated for evidence of hormonal hypersecretion and/or malignancy. Because imaging modalities can reliably identify lesions that carry a high risk of malignancy, we focus on the identification of hypersecretory lesions and those with subclinical activity, particularly Cushing syndrome. Because diverse diagnostic tests and cut-offs are employed, the prevalence of hypersecretory AI varies widely, and there is controversy regarding their long-term sequelae. In this article we provide information regarding current radiological means to define the nature of AI, and the most appropriate biochemical tests for delineating hypersecretory states. We also discuss the duration and intensity of AI follow-up as well as the identification of AI that require specific therapeutic intervention. © 2012 Elsevier Ltd.


Chrisoulidou A.,Theagenio Hospital | Boudina M.,Theagenio Hospital | Karavitaki N.,Churchill Hospital | Bili E.,Aristotle University of Thessaloniki | Wass J.,Churchill Hospital
Hormones | Year: 2015

The pituitary gland is significantly affected during gestation in terms of both size and function. Due to this physiologic adaptation, endocrine evaluation and interpretation of imaging is far more complex than in the non-pregnant state. Pituitary disorders are rare in pregnancy, as they are usually associated with gonadal dysfunction, thereby posing difficulties with fertility. This review will focus on pituitary adenomas (prolactinomas, GH-secreting and ACTH-secreting), their diagnostic handicaps and the recommendations for treatment. We will also discuss the two pituitary disorders encountered in pregnancy, Sheehan’s syndrome and lymphocytic hypophysitis. © 2015, Hellenic Endocrine Society. All rights reserved.


Economidou D.,Aristotle University of Thessaloniki | Stavrinou E.,Aristotle University of Thessaloniki | Giamalis P.,Aristotle University of Thessaloniki | Dimitriadis C.,Aristotle University of Thessaloniki | And 2 more authors.
American Journal of Kidney Diseases | Year: 2011

In recent years, a common strategy for the prevention of postsurgical intra-abdominal adhesions has been intrasurgical placement of adhesion barriers into the peritoneal cavity. Osmotic agents, such as various polysaccharides, frequently are used as antiadhesive materials. The effects of these materials on kidney function have not yet been studied. We report a case of an individual with pre-existing chronic kidney disease who developed acute kidney injury after surgical placement of an antiadhesive barrier of macromolecular polysaccharides. A kidney biopsy, performed because of persistent kidney failure, showed tubular cell lesions compatible with osmotic nephrosis lesions. This case suggests that use of polysaccharide-containing antiadhesive barriers can induce severe kidney damage. Such barriers should be used with caution in patients with abnormal kidney function to prevent irreversible damage. © 2011 National Kidney Foundation, Inc.


Chrisoulidou A.,Theagenio Hospital | Goulis D.G.,Aristotle University of Thessaloniki | Iliadou P.K.,Theagenio Hospital | Dave J.R.,Royal Brompton Hospital | And 4 more authors.
Hypertension in Pregnancy | Year: 2011

Objective. To investigate whether Chlamydia pneumoniae (Cp) infection is more common in women whose current pregnancy is complicated with preeclampsia (PE) as compared to pregnant women without PE. Methods. Thirty pregnant women with PE and 30 pregnant women without PE were studied between 29 and 30 weeks of gestation. The presence of an acute or chronic Cp infection was determined by the estimations of serum IgG, IgM, and IgA Cp antibodies. Results. None of the women were diagnosed as having acute Cp infection. Prevalence of chronic Cp infection was 53 and 66% in the PE and control groups, respectively (X 2, p = 0.068). Conclusion. Chronic Cp infection is not more common in women whose pregnancy is complicated with PE as compared to pregnant women without PE. Therefore, no association between Cp infection and PE can be established. © 2011 Informa Healthcare USA, Inc.


Barbetakis N.,Theagenio Hospital | Asteriou C.,Theagenio Hospital | Kleontas A.,Theagenio Hospital | Karvelas C.,Theagenio Hospital
Tuberkuloz ve Toraks | Year: 2011

A case of a sternal mass mimicking a chest wall tumor and finally diagnosed as primary sternal tuberculosis is presented. Fine needle biopsy was inconclusive and surgery included excision and drainage of a large abscess in the soft tissues around the involved bone. Pathology revealed multiple granulomatous and necrotic lesions consistent with tuberculous osteomyelitis. On a 4-drug antituberculous regimen the patient is an excellent condition 6 months later.


Pazaitou-Panayiotou K.,Theagenio Hospital | Papapetrou P.D.,Alexandra Hospital | Chrisoulidou A.,Theagenio Hospital | Konstantinidou S.,Theagenio Cancer Hospital | And 6 more authors.
Experimental and Clinical Endocrinology and Diabetes | Year: 2012

Objective: To investigate if serum 25-hydroxyvitamin D (25(OH)D) is related to the whole Body Surface Area (BSA), and to several other anthropometric and environmental factors. Materials/Methods: Serum 25(OH)D was determined in 489 apparently healthy subjects (346 women and 143 men, mean age 43.9 years) in April and May. From all subjects the following data were available: height, body weight, waist to hip ratio, BSA, BMI, environment of work (indoors vs. outdoors), habit of regularly sunbathing during previous summer(s), fear of sun, dwelling in city or village, and skin color. Results: Approximately 43% of the participants had serum 25(OH)D levels between 10 and 20ng/ml, 44% had values between 20.1 and 30ng/ml, whereas about 5% had values below 10ng/ml and only 9% had values above 30ng/ml. There was a significant positive relationship between 25(OH)D, height and BSA, which was more pronounced for BSA in obese subjects even after adjustment for work outdoors and sunbathing during previous summer(s). Outdoor workers and sunbathers had higher 25(OH)D compared to indoor workers and non-sunbathers respectively. Men when compared to women had higher 25(OH)D regardless of BMI and this difference was apparently due to the fact that men were taller, had greater BSA, and worked more often outdoors. Conclusions: Height, whole BSA, gender, working outdoors and sunbathing in previous summer(s) proved to be significant determinants of serum 25(OH)D. Vitamin D status is higher in taller individuals with greater BSA, and in men when compared to women. © Georg Thieme Verlag KG Stuttgart - New York.


PubMed | Theagenio Hospital
Type: Clinical Trial | Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association | Year: 2012

To investigate if serum 25-hydroxyvitamin D (25(OH)D) is related to the whole Body Surface Area (BSA), and to several other anthropometric and environmental factors.Serum 25(OH)D was determined in 489 apparently healthy subjects (346 women and 143 men, mean age 43.9 years) in April and May. From all subjects the following data were available: height, body weight, waist to hip ratio, BSA, BMI, environment of work (indoors vs. outdoors), habit of regularly sunbathing during previous summer(s), fear of sun, dwelling in city or village, and skin color.Approximately 43% of the participants had serum 25(OH)D levels between 10 and 20ng/ml, 44% had values between 20.1 and 30ng/ml, whereas about 5% had values below 10ng/ml and only 9% had values above 30ng/ml. There was a significant positive relationship between 25(OH)D, height and BSA, which was more pronounced for BSA in obese subjects even after adjustment for work outdoors and sunbathing during previous summer(s). Outdoor workers and sunbathers had higher 25(OH)D compared to indoor workers and non-sunbathers respectively. Men when compared to women had higher 25(OH)D regardless of BMI and this difference was apparently due to the fact that men were taller, had greater BSA, and worked more often outdoors.Height, whole BSA, gender, working outdoors and sunbathing in previous summer(s) proved to be significant determinants of serum 25(OH)D. Vitamin D status is higher in taller individuals with greater BSA, and in men when compared to women.


PubMed | Theagenio Hospital
Type: Case Reports | Journal: Tuberkuloz ve toraks | Year: 2011

A case of a sternal mass mimicking a chest wall tumor and finally diagnosed as primary sternal tuberculosis is presented. Fine needle biopsy was inconclusive and surgery included excision and drainage of a large abscess in the soft tissues around the involved bone. Pathology revealed multiple granulomatous and necrotic lesions consistent with tuberculous osteomyelitis. On a 4-drug antituberculous regimen the patient is an excellent condition 6 months later.


PubMed | Theagenio Hospital
Type: Case Reports | Journal: Tuberkuloz ve toraks | Year: 2012

Actinomyces israelii usually causes chronic suppurative and granulomatous infections. Isolated pleural effusion due to Actinomycosis is rare. This report describes an unusual case of thoracic empyema caused by A. israelii with sudden onset and rapid deterioration that failed to respond to chest tube drainage and antibiotherapy. Empyema drainage and visceral parietal pleurectomy by a left postolateral thoracotomy proved to be of vital importance and a permanent solution.

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