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Kashanskiy S.V.,The Workers Lab | Andre N.,Service dOncologie Pediatrique | Andre N.,French Institute of Health and Medical Research
Bulletin du Cancer | Year: 2010

Paediatric mesothelioma is a very rare entity. We report here epidemiologic data from 489 cases reported in international medical literature. A better knowledge about this entity is mandatory to improve its management. ©John Libbey Eurotext.

Choi H.M.,Korea Workers Compensation and Welfare Hospital | Choi M.H.,The Workers Lab | Yang Y.W.,Korea Workers Compensation and Welfare Hospital
American Journal of Therapeutics | Year: 2016

Teicoplanin is reported to be as effective as vancomycin but with minimal side effects. We report a case of teicoplanin-induced pancytopenia, which has not been demonstrated previously. A 44-year-old man with tetraplegia was treated with a diagnosis of urinary tract infection and pneumonia, and a high-dose of teicoplanin (400 mg every 12 hours) was administered for 4 days inadvertently. Although the infection rapidly improved, the patient developed pancytopenia by the fourth day of teicoplanin therapy, which was improved after reducing the dose of teicoplanin (200 mg/d). Our patient represents a probable case of teicoplanin-induced pancytopenia with adverse drug reaction probability score of 6. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.

Fabrizi G.,The Workers Lab | Fioretti M.,The Workers Lab | Rocca L.M.,The Workers Lab | Curini R.,The Workers Lab
Analytical and Bioanalytical Chemistry | Year: 2012

With the aim of establishing exposure levels for hospital personnel preparing and administering cytostatic drugs (CDs), here, we present an innovative screening method based on the use of the desorption electrospray ionization (DESI) interface coupled with a hybrid quadrupole linear ion trap mass spectrometer. A rapid, simple, and sensitive procedure was developed for the simultaneous surface monitoring of cyclophosphamide, dacarbazine, methotrexate, vincristine, gemcitabine, and cytarabine. Since analytes were in the solid state, a novel approach based on the use of passive samplers was combined with the direct analysis of wipes. A PTFE-printed glass slide was used as a passive sampler, while hydrophobic centers of Swiffer ® cloths were judged extremely efficient as wipe samplers. After the sampling period, the CD collectors were directly processed with the DESI-MS system without any further treatment. MS/MS confirmatory analysis was conducted using selected reaction monitoring in the positive ion mode and detection limits were evaluated. Values were at the picograms per square millimeter levels on the passive collector and at the picograms per square centimeter levels for the wipe ones. Direct determination on solid-state samples combined with mass spectrometry selectivity provided a powerful tool so far unapplied to occupational hygiene. © Springer-Verlag 2011.

Gentili A.,University of Rome La Sapienza | Caretti F.,University of Rome La Sapienza | Bellante S.,University of Rome La Sapienza | Mainero Rocca L.,The Workers Lab | And 2 more authors.
Analytical and Bioanalytical Chemistry | Year: 2012

The main difficulties in analysing non-steroidal anti-inflammatory drugs (NSAIDs) in food and biological samples are due to the tight non-covalent interactions established with matrix proteins and the amount of occurring fatty material. The present paper describes an effective extraction procedure able to isolate fifteen NSAIDs (acetaminophen, salicylic acid, ibuprofen, diclofenac, flunixin and its metabolite 5-hydroxy-flunixin, nimesulide, phenylbutazone, meclofenamic acid, tolfenamic acid, meloxicam, carprofen, ketoprofen, naproxen and etodolac) from bovine milk and muscle tissue through two succeeding steps: (a) deproteinisation/extraction with organic solvent, essential to lower the medium dielectric constant and, therefore, to release the analytes from matrix; (b) SPE clean-up on OASIS cartridges. Lipids were easily removed during low-temperature centrifugations. The advantages of the developed procedure pertain to the efficient removal of the fat substances (very low matrix effect and high recovery yields) and its versatility, since it can be applied both to milk and muscle with few adjustments due to the diversity of the two matrices. Ion-pairing reversed-phase chromatography combined with the negative electrospray detection was able to achieve low detection capabilities (CCβs) for all analytes and, in particular, for diclofenac whose Maximum Residue Limit (MRL) in milk is 0.1 μg kg-1. The methods were validated according to the guidelines of the Commission Decision 2002/657/EC and then applied for a small monitoring study. A number of samples showed traces of salicylic acid (SA), but its occurrence was not ascribed to a misuse of drugs (aspirin, salicylic acid) since SA, accumulating in plants in response to a pathogen attack, may be introduced into the food chain. © 2012 Springer-Verlag.

Fabrizi G.,The Workers Lab | Fioretti M.,The Workers Lab | Mainero Rocca L.,The Workers Lab
Biomedical Chromatography | Year: 2016

A fast and easy tailored dispersive solid-phase extraction (d-SPE) procedure has been developed for the determination of 13 cytostatic drugs. Combined with a rapid and simultaneous ultra performance liquid chromatography/tandem mass spectrometry method for residue identification and quantification in urine, it has been fully validated and tested to study a realistic situation in working environment. The target compounds were chosen from the most common classes used in hospitals. The d-SPE adsorbent was obtained mixing Oasis HLB® with C18 and applied to a large volume of sample (10 mL). The electrospray ionization-mass spectrometry acquisition was conducted in a mixed period mode: six acquisition windows were in positive ionization and one in negative (for 5-fluorouracil). The lowest limit of quantification was found at 0.04 μg/L urine for methotrexate. The absolute recovery of cytotoxic drugs was assessed at two concentrations levels and ranged from 67.1% (cytarabine) to 102.3% (etoposide) and from 65.3% (cytarabine) to 101.2% (methotrexate) for the lower and higher levels, respectively, with the relative standard deviation always <12%. This method gives the opportunity to analyze drugs in a wide molecular weight range (from 130 to 853 a.m.u.) and in a complex matrix, such as urine, without losing any of the features that a method intended for trace quantification must have. © 2016 John Wiley & Sons, Ltd.

Fabrizi G.,The Workers Lab | Fioretti M.,The Workers Lab | Mainero Rocca L.,The Workers Lab
Analytical and Bioanalytical Chemistry | Year: 2013

A desorption study of 57 volatile organic compounds (VOCs) has been conducted by use of accelerated solvent extraction (ASE) and gas chromatography-mass spectrometry. Different solvents were tested to extract activated charcoal tubes with the objective of replacing carbon disulfide, used in official methods, because of its highly toxic health and environmental effects. Extraction conditions, for example temperature and number of cycles, were investigated and optimized. The definitive extraction procedure selected was use of acetone at 150 °C and two consecutive extraction cycles at a pressure of 1,500 psi. Considering a sample volume of 0.005 Nm3, corresponding to a sampling time of 8 h at a flow rate of 0.01 L∈min -1, the method was validated over the concentration range 65-26,300 μg∈Nm-3. The lowest limit of quantification was 6 μg∈Nm-3, and recovery for the 93 % of analytes ranged from 65 to 102 %. For most of the compounds, relative standard deviations were less than 15 % for inter and intra-day precision. Uncertainty of measurement was also determined: the relative expanded uncertainty was always below 29.6 %, except for dichlorodifluoromethane. This work shows that use of friendlier solvent, for example acetone, coupled with use of ASE, can replace use of CS2 for chemical removal of VOCs from activated charcoal. ASE has several advantages over traditional solvent-extraction methods, including shorter extraction time, minimum sample manipulation, high reproducibility, and less extraction discrimination. No loss of sensitivity occurs and there is also a salutary effect on bench workers' health and on the smell of laboratory air. [Figure not available: see fulltext.] © 2012 Springer-Verlag.

Castellano P.,The Workers Lab | Canepari S.,University of Rome La Sapienza | Ferrante R.,The Workers Lab | L'Episcopo N.,The Workers Lab
Journal of Environmental Monitoring | Year: 2012

The aim of this work was the study, by a multiparametric approach, of emissions from a laser printer in an experimental box-chamber, with particular attention to nanoparticles release. The experimental design included number concentration measurements by Fast Mobility Particle Sizer (FMPS) and chemical characterizations (elements) of size segregated samples collected by Nanomoudi cascade impactor. Volatile Organic Compounds (VOCs) were also sampled by charcoal sorbent tubes by personal sampling pumps. Monitoring of ozone, total volatile organic compounds concentrations and of temperature and humidity values inside the experimental box during the printing processes were also performed by automatic analyzers. The performed monitoring allowed to evidence different ways for particles emissions by laser printers, in particular showing that nanoparticles, characterised by high concentrations of Ba, Zn, B, K, Sr and Na, are set free at the beginning of the printing process. This emission seems to be directly ascribable to the use of toner powder, as all these elements are present in it. The emission of larger particles (ca. 100-320 nm) was observed in subsequent phases of the print process, probably due to the condensation of vapours released during the progressive heating of the fuser roller. This contribution was proved by both the FMPS measurements and the cascade impactor results. Also, a low emission of particles in higher size ranges was evidenced, mainly due to paper related particles. A very high concentration of VOCs was detected inside the chamber and the chemical speciation shows that the major contribution is associated to toner components, even if some species are released from other printer components. Although the formation of secondary species by reaction of VOCs with ozone cannot be excluded, these species were present inside the chamber at concentrations lower than the detection limit. © 2012 The Royal Society of Chemistry.

Correia F.V.,The Workers Lab | Moreira J.C.,The Workers Lab
Bulletin of Environmental Contamination and Toxicology | Year: 2010

Laboratory tests were conducted to compare the effects of various concentrations of glyphosate and 2,4-D on earthworms (Eisenia foetida) cultured in Argissol during 56 days of incubation. The effects on earthworm growth, survival, and reproduction rates were verified for different exposure times. Earthworms kept in glyphosatetreated soil were classified as alive in all evaluations, but showed gradual and significant reduction in mean weight (50%) at all test concentrations. For 2,4-D, 100% mortality was observed in soil treated with 500 and 1,000 mg/kg. At 14 days, 30%-40% mortality levels were observed in all other concentrations. No cocoons or juveniles were found in soil treated with either herbicide. Glyphosate and 2,4-D demonstrated severe effects on the development and reproduction of Eisenia foetida in laboratory tests in the range of test concentrations. © Springer Science+Business Media, LLC 2010.

News Article | May 8, 2015
Site: www.fastcompany.com

In stories of the tech industry, it’s not uncommon to hear about prodigies who’ve dropped out of college once they have the skills to snag a six-figure salary. Right behind them are high school grads enrolling in hacker schools and alternative programs, and also heading off to hefty salaries. But for many, the reality is a lot starker. The recession brought hard times across economic strata, but as the economy has revived, it has left many more behind. The U.S. leads the world in low-wage work, and those paychecks have declined by 5% over the 1979–2013 period, despite a generation of productivity gains (64.9%), according to the Economic Policy Institute, which also projects that over one in four workers (28%) will be in low-wage jobs in 2020. Carmen Rojas witnessed this firsthand. A first-generation Latina, she was raised by parents who didn’t graduate from high school, and with siblings who had no aspirations to attend college. Friends and other family members were all low-wage workers. Rojas chose a different path, graduating from UC Berkeley with a PhD in city and regional planning, and going on to nonprofit work serving the needs of low-income communities and minorities in the Bay Area before landing at Living Cities, where she worked with 22 of the largest foundations and financial institutions in the world to improve opportunities for low-income people. It would become the springboard to launch The Workers Lab. In less than six months, Rojas and three others developed a strategy for an accelerator that invests in entrepreneurs, community organizers, technologists, economic justice organizations, issue campaigns, and businesses, to create scalable and self-sustaining solutions that improve conditions for low-wage workers. From the beginning, Rojas admits that even with her PhD, she wasn’t an expert on labor policy, entrepreneurship, or investments, but that actually served her well in making connections. She listened, asked questions, even suspended disbelief when it was called for. "I settled into curiosity in order to satisfy my appetite to be of service," she writes. Thus the goal of The Workers Lab to vet ideas, services, and products from a wide range of individuals came into focus. It would attract over 200 applications, the majority of which were nonprofits seeking recoverable grants and 40% of which were startups looking for equity investments to build out ideas like a digital gaming app to retrain fast food workers to get better-paying jobs. It’s a bit too early to tell how these early bids for investment will fare, but this work and much of Rojas’s career have been a carefully choreographed dance between advocating for low-wage workers and moving the big corporate and governmental institutions capable of taking action to make change. For this, she credits her upbringing and being a Latina woman as competitive advantages. "Growing up, I was surrounded by people who looked and talked more like me than any of my academic or professional counterparts ever did," Rojas tells Fast Company. This is still the case, she observes. "Latinas represent nearly 17% of women in the U.S. and only 5% of PhD graduates," Rojas explains. "On the other hand, women of color represent nearly 60% of full-time minimum-wage workers." Rojas views her advanced degree as a gift despite the fact that she had "tens of thousands of dollars in student loans" in addition to having to work throughout the program and take financial aid—in sharp contrast to many of her academic counterparts whose parents could afford to send them to college. "Practically speaking, I spend a lot of time with my family and friends who work in low-wage industries and organize low-wage constituencies, making the reality of low-wage workers ever present in my work," she says. As for dedicating herself to service, Rojas recalls that her parents both came from big families. "My mom has 17 siblings and my dad has 10 siblings," and as conditions in their home countries of Nicaragua and Venezuela deteriorated due to civil war, economic crises, and violence, their siblings and families started to immigrate to the U.S. "Our home represented the first stop for many of those families," Rojas recounts. "My parents never questioned whether they were going to open their home to families of four or five. They just did it." As homeowners, Rojas’s parents were able to give the newly arrived a place of respite before starting a new life, she says. "They showed me that being of service would significantly improve conditions for our entire family, and, in a broader context, to people in need in our greater community," says Rojas, adding that it remains a lesson she brings to work daily. Being a woman has also been an advantage because women represent the vast majority of low-wage earners, she says. "Many of these women have children or are caretakers for older family members, and the vast majority of them are working under impossible conditions to make ends meet." The women in her family were no different, she says. "Many continued to work in childcare, sweatshops, elder care, and food service, all while making sure their kids were fed, dressed, and safe." Rojas says it’s impossible to do what she does without being reminded on a daily basis that women—especially women of color—bear the brunt of unequal pay and uneven protection in the workplace. Latina women in the U.S. earn only 53% of what white men earn for comparable work, according to the AAUW (American Association of University Women). To connect with corporations and other organizations that are profit-driven is a tough but necessary part of advocacy because they have the power to transform working conditions for low-wage earners. For now, Rojas points to current examples of companies such as Costco and Gravity Payments that offer a living wage and benefits such as paid sick time, and the business case for doing the right thing. "When these conditions are met, corporations and revenue-generating ventures experience less employee turnover and have increased customer loyalty," she says. "This is great for their corporations as well as for our economy."

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