Salgado R.,Institute Jules Bordet |
Denkert C.,Charite University Hospital |
Demaria S.,New York University |
Sirtaine N.,Free University of Colombia |
And 31 more authors.
Annals of Oncology | Year: 2015
Evidence is strengthening for the morphological evaluation of tumor infiltrating lymphocytes (TILs) in breast cancer. Herein, the concepts for TILs assessment are laid out by pathologists to facilitate their wider evaluation and consistent interpretation. The goal of this article is to promote the evaluation of TILs as a biomarker in research, clinical trial settings and day-to-day practice. © The Author 2014. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.
Mihu C.N.,The Ut Md Anderson Cancer Center |
Rhomberg P.R.,Jones Microbiology Institute Laboratories |
Jones R.N.,Jones Microbiology Institute Laboratories |
Coyle E.,University of Houston |
And 2 more authors.
Diagnostic Microbiology and Infectious Disease | Year: 2010
As part of Meropenem Yearly Susceptibility Test Information Collection/USA Surveillance Programme, we monitored the occurrence of quinolone resistance in Escherichia coli over a 10-year period. A total of 271 E. coli isolates from our institution were tested over a 10-year period. Screening for quinolone resistance (qnr) gene was performed. A decline in susceptibility of E. coli isolates to quinolones and aminoglycosides was noted over the 10-year span (P < 0.0001), which was significantly reduced compared with the average susceptibility of all sites. Introduction of quinolone prophylaxis has led to a significant decline in susceptibility of E. coli to all quinolones. The organisms remain susceptible to carbapenems, cefepime, and piperacillin/tazobactam. Periodic surveillance allows for detection of resistance patterns and adjustment of empiric antibiotic choice in patients at high risk for infection. © 2010 Elsevier Inc.
Akhter S.,The Ut Md Anderson Cancer Center |
Lam Y.C.,The Ut Md Anderson Cancer Center |
Chang S.,The Ut Md Anderson Cancer Center |
Legerski R.J.,The Ut Md Anderson Cancer Center
Aging Cell | Year: 2010
Conserved metallo β-Lactamase and β-CASP (CPSF-Artemis-Snm1-Pso2) domain nuclease family member SNM1B/Apollo is a shelterin-associated protein that localizes to telomeres through its interaction with TRF2. To study its in vivo role, we generated a knockout of SNM1B/Apollo in a mouse model. Snm1B/Apollo homozygous null mice die at birth with developmental delay and defects in multiple organ systems. Cell proliferation defects were observed in Snm1B/Apollo mutant mouse embryonic fibroblasts (MEFs) owing to high levels of telomeric end-to-end fusions. Deficiency of the nonhomologous end-joining (NHEJ) factor Ku70, but not p53, rescued the developmental defects and lethality observed in Snm1B/Apollo mutant mice as well as the impaired proliferation of Snm1B/Apollo-deficient MEFs. These findings demonstrate that SNM1B/Apollo is required to protect telomeres against NHEJ-mediated repair, which results in genomic instability and the consequent multi-organ developmental failure. Although Snm1B/Apollo-deficient MEFs exhibited high levels of apoptosis, abrogation of p53-dependent programmed cell death did not rescue the multi-organ developmental failure in the mice. © 2010 The Authors. Aging Cell © 2010 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland.
Stover R.J.,University of Texas at Austin |
Joshi P.,University of Texas at Austin |
Yoon S.J.,University of Texas at Austin |
Murthy A.K.,University of Texas at Austin |
And 4 more authors.
Optical Molecular Probes, Imaging and Drug Delivery, OMP 2015 | Year: 2015
We present biodegradable gold nanoparticles with plasmon resonances in the NIR region that can provide a crucial link between the enormous potential of metal nanoparticles for cancer imaging and therapy and translation into clinical practice. © OSA 2015.