The University Of Texas and Mission Pharmacal Co. | Date: 2011-06-07
Small molecules and their derivatives are described for the treatment and/or prevention of intestinal fluid loss. Also disclosed are methods of using said molecules and their derivatives to treat and/or prevent conditions associated with increased levels of 3,5-adenosine monophosphate. Specific compositions of the invention are also novel.
The University Of Texas | Date: 2010-02-01
Enantomerically purified phenothiazines are provided as active ingredients of medicaments to limit activity of bone resorbing cells so as to reduce bone loss. Novel phenothiazine derivatives are provided. A method of synthesizing enantiomerically pure phenothiazine derivatives is provided that avoids post-synthetic enantiomeric resolution.
News Article | January 20, 2016
Almost a decade ago, I started designing services for theme parks, a job that’s harder than you might think. It takes extraordinary effort to make theme parks believable. To be believable, they must be immersive. To be immersive, they must be technologically sophisticated. But make them too sophisticated, and they’re no longer believable. The best theme parks use technology as a means to an end, freeing visitors to become joyously lost in the moment. They feel simple, intuitive, and magical. Understanding how theme parks enchant visitors could help us redesign some of our most important social institutions—like hospitals, schools, and other environments—that have become mind-numbingly tedious. Immersive worlds have a rich history. From the municipal parks of Frederick Law Olmsted to the World Expositions to modern-day theme parks, examples abound of aspirational utopias that let you travel without leaving home. Technology has always figured prominently in creating a theme park’s fantasy. Think about the 3-D rides at Universal Studios and the optical illusions and animatronics at Disneyland’s Haunted Mansion. Today, technology is also being used to improve some of the more mundane aspects of an amusement park’s experience, so that the magic doesn’t stop when you climb off the roller-coaster. Tens of thousands of people have already used My Disney Experience, a system that includes a booking engine and mobile app to create and modify plans at Walt Disney World Resort in real time, as well as an electronic wristband called the Disney Magic Band to avoid lines, automate payments, and have personalized interactions with Disney characters and rides within the park. The goal of Disney’s system, and others such as Vail’s longstanding RFID ski passes, is to remove logistical obstacles to the enjoyment of the things the visitor is really there to see. So what does a well-designed environment look like? Varied rhythms are key—you need enough to engage you but not so much you get exhausted or stressed out. Think about what guided one of the original "experience designers," Frederick Law Olmsted, who created Central Park in New York City and the Emerald Necklace in Boston. Olmsted had a knack for arranging natural scenery to create a sense of mystery and discovery, which drew people in and ushered them smoothly through a space. More than a century later, his work influences Disney parks, where the park architects mix "decompression zones" in with the attractions to let people rest before finding something new to explore. A careful observer may notice that the middle sections of many Disney buildings are fairly plain, saving the ornate details for the corners. It creates a kind of visual friction that draws your eye and sparks curiosity. It can be seen as a kind of greeble—the model maker’s trick of adding non-essential surface details—to add a bit of novelty and visual intrigue, and to keep you moving. Visitors also respond well to an experience that feels like a good story—it has a clear beginning, middle, and end. Common types of digital technologies can create this kind of narrative in the physical world: a sign-up and booking engine before you start your journey, a wayfinding tool when you’re in the thick of it, and a way to capture and relive your memories later, or pick back up where you left off. Something as simple as the "impromptu" dance party that takes place at the end of the Minions attraction in Universal Parks creates a sense of celebration to the experience the Guest has just had, and primes them for experiences to come. (The way Uber also books, tracks and then rates drivers when using their service also applies here as well.) The idea is to replace transactional moments that dehumanize visitors with scenes and rituals that feel important. The technologies and narrative devices common at theme parks could be easily applied to other institutions. Consider the hospital or medical clinic of the near future. While you don’t expect to have fun visiting one of these places, you do at least hope to avoid being overwhelmed, bored, annoyed, confused, or frightened. Taking a "guest-first" approach, in the parlance of the theme park industry, the hospital offers a computer system that, through a series of encounters, gets to know you, and across visits remembers you and your medical history. It allows the hospital to route you through an experience that feels relatively stress-free, intuitive, supportive and, most importantly, centered around you. Logistics like transportation are orchestrated for you, redundant administrative tasks are minimized, and doctors and nurses have information at their fingertips that helps them put your care first. Something that is typically cold and impersonal becomes simple and human, not just while you’re in the building, but before and after your visit, within the larger context of your personal health. Education is another area where expertly managing the experience is critical. As with healthcare, the physical location, the campus, is only part of the story. At Big Tomorrow we worked with The University of Texas Rio Grande Valley (UTRGV) to design a better experience for students who juggle family and work responsibilities and often travel long distances for school. Rather than build a single new, state-of-the-art, centralized campus, we recommended smaller buildings integrated with neighborhoods and community hubs where students could have access to Wi-Fi, group study spaces, childcare services, and areas where they could virtually connect into their classes if they couldn’t make it in person. We also proposed a Wi-Fi-enabled bus system to move people in a timely fashion and allow students to fit family, work, and school into their schedules. In each of these examples, new technology has been introduced, seemingly without too much of a "complexity tax" on the user. The trick is to deploy technology strategically and sparingly, since new tools tend to introduce unintended complexities. Look around any public space and you’ll see people absorbed in their devices, attending to a thousand little tasks but arguably not living in the moment. Have you ever struggled with uncooperative GPS to locate your approaching Uber, as empty cabs whisked past you? Like Mickey Mouse as the Sorcerer’s Apprentice in the Disney film Fantasia, we sometimes find that our tools take on a life of their own, making us a slave to them rather than the other way around. Moreover, with any commercial experience there’s an inevitable tension between putting people first and turning a profit. Who hasn’t grumbled about overpriced concessions and endless ads at a movie theater? A hospital patient may feel similarly overwhelmed by impersonal and bureaucratic processes that seem to serve the health care provider at their expense. Just because we have the technology to do something, doesn’t mean we should. Particularly with healthcare, we expect that things will not only go smoothly but also quickly—that unnecessary friction is removed from the process. But remove too much friction, and the process becomes unpalatably fast—to the point of seeming hurried, cursory, and impersonal. The key is to use friction points for pacing and transitions, like sign posts on a journey to relieve the user’s anxiety and focus on the important stuff. Thus a hospital would minimize unhelpful friction like complex elevator controls or repetitive check-in procedures, and increase the amount of helpful friction, like spontaneous interactions with staff who greet you by name, support you, and encourage you during your visit. It seems obvious that reducing complexity and clarifying expectations can create enjoyable, visceral experiences. But an overly simplified experience can be problematic, too. People like to have choices, but not so many that they can’t relax and enjoy themselves in the moment. The designer’s job is to strike that balance. Great design starts by following the rhythms of life and one’s heart. It ends with something that delights, surprises, and even exceeds users’ expectations. Just ask Olmsted.
The University Of Texas and Volcano Corporation | Date: 2010-02-10
Mosquitoes are deadly efficient at spreading disease. Despite vaccines and efforts to eradicate the pesky insects, they continue to infect humans with feared diseases like Zika virus, malaria and West Nile virus. Gaining the upper hand on mosquitoes requires speed. Their life cycle is typically two weeks or less and they need only warm weather and standing water to breed. Robert Meagher, a chemical engineer at Sandia National Laboratories, has developed a simple technique for simultaneously detecting RNA from West Nile and chikungunya virus in samples from mosquitoes. He is now working to add the ability to screen for Zika virus. "Our ultimate goal is to develop an autonomous device to passively monitor for mosquito-borne diseases," Meagher explained. "But first you need an assay that is more robust than the gold standard in a laboratory and that has a very low false-positive rate." Meagher and Sandia colleagues Yooli Light, Chung-Yan Koh and postdoctoral researcher Cameron Ball describe the technique in a paper published online in Analytical Chemistry, "Quenching of unincorporated amplification signal reporters (QUASR) in RT-LAMP enables bright, single-step, closed-tube and multiplexed detection of RNA viruses." They explored reverse-transcription loop mediated isothermal amplification (RT-LAMP), an isothermal nucleic acid amplification technique used instead of the more common polymerase chain reaction (PCR) for low-cost or point-of-care diagnostics for infectious diseases. However, in its usual form, RT-LAMP requires too many manipulations or elaborate instrumentation to be suitable for field use or an autonomous device. RT-LAMP relies on primers, DNA fragment sequences, that bind to a target -- the RNA of the virus of interest -- and then generate a large amount of DNA. By fluorescently labeling the primer, the new DNA glows as it is produced. If the primer doesn't find the viral RNA, there is no glow. The Sandia researchers added a different DNA fragment sequence called a quench probe that complements a short stretch of primer. As the reaction takes place, the quench probe suppresses any unincorporated primer. This amplifies the positive signal up to 10 times brighter than a negative signal. Because the signal is so bright, QUASR can screen up to three different targets simultaneously, saving time and money. "We didn't expect a signal that bright, so we came up with the name QUASR, inspired by quasars, the extremely luminous celestial objects that can be a trillion times brighter than the sun," Meagher said. QUASR is simple enough to be used in a field laboratory. The Sandia team is working to incorporate QUASR into a handheld device. Vector-control districts stand to benefit greatly from QUASR. Such districts are typically the part of public health agencies that monitors and controls disease-carrying insects locally. Currently, detecting disease-carrying mosquitoes is a complex and lengthy process. A field worker in a vector control district collects and prepares mosquito samples, which are then sent to a lab for testing using sophisticated PCR techniques. Using QUASR, either in a portable microfluidic device or simple field laboratory, a user can get a definitive yes or no result in about half an hour. More details like the amount of viral RNA present in the sample would still require laboratory PCR. "This would allow those in the field to make quick decisions on mosquito abatement that can prevent the spread of disease," Meagher said. QUASR also can be adapted to screen people for diseases such as the Zika virus or Ebola virus. This is a constantly changing landscape; a year ago, few people had even heard of Zika virus, which the World Health Organization recently declared an international health emergency. "Conceptually, it's not difficult to adapt the assay for a different virus," said Meagher. "There is some trial and error involved in refinement as you are dealing with a different virus and human sample." Meagher recently received a National Institutes of Health (NIH) grant to develop a field-deployable assay for differential diagnosis of malaria and viral febrile illnesses including Ebola. The University of Texas Medical Branch at Galveston is a partner in the grant. Because malaria and Ebola have similar symptoms -- fever, chills, headache, diarrhea and vomiting -- health officials worry that patients with malaria are being sent to Ebola quarantine wards. "A point-of-care device that can quickly discriminate Ebola from malaria in a blood sample would prevent dangerous misdiagnoses," said Meagher. Lassa, dengue and other febrile illnesses are also targets for the NIH project. Meagher and his team set out to tackle the problem of false positives. "Even a marginal false positive rate would defeat the purpose of an autonomous monitoring device," he said. "The signal amplification, the amazing brightness of the positive response, was not a goal but certainly a welcome result. While the human eye can only effectively discriminate three distinct colors, the team is developing imaging technology that could enable simultaneous screening of even more targets. "I'm very excited about what this technique can do for field workers," Meagher said. "The ability to make fast decisions about where to direct mosquito abatement resources or how to triage patients will help us stay ahead of mosquito-borne disease outbreaks."