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Naha-shi, Japan

Hamner C.,Washington State University | Zhang Y.,University of Queensland | Zhang Y.,The University of Okinawa | Khamehchi M.A.,Washington State University | And 2 more authors.
Physical Review Letters | Year: 2015

We investigate a spin-orbit-coupled Bose-Einstein condensate loaded into a translating optical lattice. We experimentally demonstrate the lack of Galilean invariance in the spin-orbit-coupled system, which leads to anisotropic behavior of the condensate depending on the direction of translation of the lattice. The anisotropy is theoretically understood by an effective dispersion relation. We experimentally confirm this theoretical picture by probing the dynamical instability of the system. © 2015 American Physical Society. Source

Shimokawa H.,Tohoku University | Tsutsui M.,The University of Okinawa
Pflugers Archiv European Journal of Physiology | Year: 2010

Nitric oxide (NO) is produced in almost all tissues and organs, exerting a variety of biological actions under both physiological and pathological conditions. NO is synthesized by three distinct NO synthase (NOS) isoforms (neuronal, inducible, and endothelial NOS), all of which are expressed in the human cardiovascular system. Although the regulatory roles of NOSs in cardiovascular diseases have been described in pharmacological studies with selective and non-selective NOS inhibitors, the specificity of the NOS inhibitors continues to be an issue of debate. To overcome this issue, genetically engineered animals have been used. All types of NOS gene-deficient animals, including singly, doubly, and triply NOS-deficient mice, and various types of NOS gene-transgenic (TG) animals, including conditional and non-conditional TG mice bearing endothelium-specific or cardiomyocyte-specific overexpression of each NOS gene, have thus been developed. The roles of individual NOS isoforms as well as the entire NOS system in the cardiovascular system have been extensively investigated in those mice, providing pivotal insights into an understanding of the pathophysiology of NOSs in human cardiovascular diseases. Based on studies with the murine NOS genetic models, this review briefly summarizes the latest knowledge of NOSs and cardiovascular diseases. © 2010 Springer-Verlag. Source

Arbuthnott G.W.,The University of Okinawa
Progress in Brain Research | Year: 2014

Over the years since the discovery of dopamine in the neostriatum, we have learned much about the anatomy of this large subcortical nucleus. In rodents, it is one nucleus penetrated by many fibers from the cerebral cortex. In larger animals and in humans, the area is split by a bundle of mainly corticofugal axons into the caudate nucleus and putamen. Dopamine input to both is similar and except for the details of cortical afferents to the two parts the striatum seems to act as one structure. Its main function is expected to be the transfer of the information carried in its cortical inputs onward through the basal ganglia. Diseases of this area of brain are associated with movement disorders and much is made of the action of dopamine on the long-term stability of corticostriatal synapses. The cortex is not at all the only input to the area, however, and the thalamus has almost as many synapses with striatal output neurons as has the cortex. This chapter summarizes the contributions to the study of the involvement of thalamostriatal inputs presented at Dopamine 2013 and emphasizes that this input, though largely ignored, has important lessons for those interested in understanding the function of the basal ganglia. © 2014 Elsevier B.V. Source

Tokushige N.,The University of Okinawa
Journal of Combinatorial Theory. Series A | Year: 2011

Let F1,...,Fr⊂([n]k) be r-cross t-intersecting, that is, |F1∩..Fr|≥t holds for all F1∈F1,...,Fr∈Fr. We prove that for every p,μ∈(0,1) there exists r0 such that for all r>r0, all t with 1≤t<(1/p-μ)r-1/(1-p)-1, there exist n0 and ∈ so that if n>n0 and |k/n-p|<∈, then |F1|··· |Fr|≤(n-tk-t)r. © 2011 Elsevier Inc. Source

Frankl P.,3 12 25 Shibuya | Tokushige N.,The University of Okinawa
Combinatorics Probability and Computing | Year: 2011

Let (r - 1)n ≥ rk and let ℱ 1,⋯,ℱ r ⊂(k/[n]). Suppose that F 1 ∩ ⋯ ∩ F r ≠ Ø holds for all F i ∈ ℱ i, 1 ≤ i ≤ r. Then we show that ∏ i=1 r |FF i| ≤ (n-1/k-1) r. © Copyright Cambridge University Press 2011. Source

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