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Nhan N.T.,The University of Medicine and Pharmacy | Van Thanh T.,The University of Medicine and Pharmacy
IFMBE Proceedings | Year: 2015

Gliclazide (GLZ) is a second-generation sulphonylurea, widely used for the treatment of non-insulin dependent diabetes mellitus. However, due to its low solubility in water (55 mg/L) and gastric fluids, its bioavailability varied inter-individual. This research aims to enhance the dissolution rate of gliclazide using in situ micronization technique. The in situ micronization process was carried out using solvent change method by using hydroxypropyl methylcellulose E15 (HPMC E15) or tween 80 as stabilizing agents. The solution of 0.5 g or 1 g of gliclazide in 30 ml of dimethyl sulfoxide was mixed with the solution containing 0,05 g or 0,1 g of HPMC E15 or tween 80 in 100 ml of water under stirring at 1200 rpm in ice bath (about 5°C) for 30 minutes. Obtained suspensions were filtered through 0,45 μm cellulose acetate membrane. The dissolution test, scanning electron microscopy, particle size analysis, Fourier transform infrared spectroscopy (FTIR) and thermal analysis (DSC) were carried out to investigate the properties of the micronized gliclazide obtained. The in situ micronization technique used in this research enhanced the water-solubility and dissolution rate of gliclazide. The crystalline shape of GLZ changed from rod-shape or cubeshape to spherical shape with smaller size. © Springer International Publishing Switzerland 2015. Source


Tilinca M.,The University of Medicine and Pharmacy | Sincu N.,The University of Medicine and Pharmacy | Toma F.,The University of Medicine and Pharmacy | Chesca A.,Transilvania University of Brasov | And 2 more authors.
Annals of the Romanian Society for Cell Biology | Year: 2013

The aim of this study is the role of Helicobacter pylori (HP) infection in pacients with non-Hodgkin's lymphomas. We have conducted a prospective case-control study. This comprised 112 patients previously diagnosed with non-Hodgkin's lymphoma (NHL) in which the identification with Helicobacter pylori infection was intended. In this regard serological methods such as ELISA technique for IgG anti-HP detection were used. The investigated lot represented pacients from Targu Mures Medical Clinic I and included 59 (52.68%) male and 66 (58.93%) patients from urban areas. We studied the association between Helicobacter pylori infection and the presence of NHL (Chi- square test, χ2 =1.91, df=1, N=224, p=0.214>0.05). 66.96% of the cases of NHL infections with HP was serologically confirmed. At the male respectively female population an association between Helicobacter pylori infection and the presence of NHL was observed but without statistical significance. In the present study, we can say that, in relation to the area of origin there is a significant statistical association between Helicobacter pylori infection and the presence of NHL. In case of the rural population there is a statistically significant high magnitude of OR. Also, at the urban population there is a statistically significant increase of the cases, but with a more reduced magnitude of OR compared with that from the rural area. Source


Podeanu M.-D.,The University of Medicine and Pharmacy | Tilinca M.,The University of Medicine and Pharmacy | Georgescu R.,The University of Medicine and Pharmacy | Treaba A.,The University of Medicine and Pharmacy | Simona S.,The University of Medicine and Pharmacy
Annals of the Romanian Society for Cell Biology | Year: 2013

The purpose of this study was to present imaging and histopathological aspects of primary mucinous cystadenocarcinoma of the breast with overview of the literature. We retrospectively reviewed all breast cancer cases admitted to the Clinical District Hospitals Mures during the last ten years (October 2003 - October 2012) and analyzed the imaging, histopathological and surgical reports of the only two found cases of primary mucinous cystadenocarcinoma of the breast. The mammographic examinations and immunohistochemical stainings were performed. Both tumours were encountered in postmenopausal women. One of the patients presented with synchronous bilateral carcinoma: breast mucinous cystadenocarcinoma grade 1 of histological malignity in the left breast and invasive ductal carcinoma - not otherwise specified (IDC-NOS) grade 2 in the controlateral breast. Mammographic and ultrasonographic examinations were unable to distinguish the breast mucinous cystadenocarcinoma from other lesions with similar features, but the diagnosis was established based on the immunohistochemical characteristics. One of the breast mucinous cystadenocarcinoma cases was triple negative and the second was strongly positive for estrogen (90%) and progesterone (90%) receptors, but HER2/neu negative. Source

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