The TsimTsoum Institute

Kraków, Poland

The TsimTsoum Institute

Kraków, Poland
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Singh R.B.,Halberg Hospital and Research Institute | Cornelissen G.,University of Minnesota | Takahashi T.,Fukuoka University | Wilczynska A.,The Tsimtsoum Institute | And 18 more authors.
World Heart Journal | Year: 2016

Background. Dr. Halberg, the Lord of Time, showed that all biological functions, including gene functions, follow a circadian rhythm. An earlier study revealed that births in September to November may program increased longevity up to 100 years. Recent studies showed that risk factors can predispose trans-generational inheritance of diseases or health from parents to offspring. This study examined the role of time of birth on the risk of cardiovascular diseases (CVDs) and other chronic diseases. Subjects and Methods. The pilot study included 100 adults aged 20 years and above to investigate any association of time of birth with future risk of CVDs and diabetes. After approval from the local Hospital Ethics Committee and obtaining written informed consent, subjects 20 years and older were recruited for the study. The sample size was based on known prevalence of hypertension, coronary artery disease (CAD), stroke and diabetes in the populations concerned. It was estimated that at least 9% of the population, aged 25 years and above, had any one or more of the above diseases. Time of birth for each subject was obtained from the individual's horoscope, in which the exact time and date of birth were recorded at the time of birth. The presence of diseases was recorded based on available records of diagnosis and treatment. Multivariate logistic regression analysis was employed to determine whether the time of birth predicts risk factors associated with various diseases. Results. The results of the study have shown that the incidence of hypertension, prehypertension and diabetes as well as prediabetes was lower among subjects who were born during the nighttime (18:00 to 6:00) compared to subjects who were born during the daytime (6:00 to 18:00). The second quarter of the day (06:00-12:00) is associated with increased sympathetic activity with its adverse effects, whereas the first quarter of the day (12:00-06:00) is associated with increased parasympathetic and low sympathetic activity with corresponding protective effectson the fetus, mother and newborn. An infant born in the second quarter may be exposed to high concentrations of catecholamines, cortisol, oxidative stress and inflammation, with low melatonin, which can damage the genome and epigenome as well as other tissues of the offspring, resulting in greater risk of diseases later in adult life. However, if the child is born during the first quarter of the day, this span is associated with increased concentrations of acetylcholine, nitric oxide and antioxidants in the tissues which have protective effects against diseases. Conclusions. Infants born in the first quarter of the 24-hour day may have lower risks of CVDs and other chronic diseases, whereas those born in the second quarter may have higher risks of diseases later in adult life. © Nova Science Publishers, Inc.


Shastun S.,Peoples' Friendship University of Russia | Chauhan A.K.,Banaras Hindu University | Singh R.B.,Halberg Hospital and Research Institute | Singh M.,CSIR - Central Electrochemical Research Institute | And 6 more authors.
World Heart Journal | Year: 2016

The world is still ignorant about the role of functional food security characterized by diversity and adequacy of nutrients that may have been beneficial and abundant in the Paleolithic diet 40,000 years ago because of food diversity. Therefore, the increased prevalence of metabolic syndrome and the resultant type 2 diabetes, hypertension and heart disease throughout the world, are closely linked to food security via westernized dietary patterns, physical inactivity, and rapid increase in the rate of obesity. There is substantial evidence that increased intake of functional foods can bring about a significant decline in the epidemic of obesity and metabolic syndrome, resulting in health promotion. We therefore propose that functional food security can maintain the normal physiology and metabolism of our bodies, resulting in prevention of diseases and improvement of world health. © 2016 Nova Science Publishers, Inc.


Singh R.B.,The TsimTsoum Institute | Gupta S.,The TsimTsoum Institute | Dherange P.,The TsimTsoum Institute | de Meester F.,The TsimTsoum Institute | And 3 more authors.
Canadian Journal of Physiology and Pharmacology | Year: 2012

Recent research indicates an association between brain dysfunction and the pathogenesis of metabolic syndrome. To investigate this, we created a Medline search (up to December 2011) of articles in PubMed. The results indicated that refined carbohydrates, saturated and total fat, high levels of ω-6 fatty acids, and low levels of ω-3 fatty acids and other long chain polyunsaturated fatty acids (PUFA), all in conjunction with sedentary behaviour and mental stress can predispose to inflammation. Increased sympathetic activity, with increased secretion of catecholamine, cortisol, and serotonin can cause oxidative stress, which may damage the arcuate nucleus as well as the hypothalamus and macrophages, and the liver may release pro-inflammatory cytokines. These, in conjunction with an underlying deficiency in long chain PUFA, may damage the arcuate nucleus as well as neuropeptide-Y and pro-opiomelanocortin neurons and insulin receptors in the brain, especially during fetal life, infancy, and childhood, resulting in their dysfunction. Of the fatty acids in the brain, 30%-50% are long chain PUFA, which are incorporated in the cell membrane phospholipids. Hence, ω-3 fatty acids, which are also known to enhance parasympathetic activity and increase the secretion of anti-inflammatory cytokines interleukin (IL)-4 and IL-10 as well as acetylcholine in the hippocampus, may be protective. Therefore, treatment with ω-3 fatty acids may be applied for the prevention of metabolic syndrome.


Alam S.E.,University of Delhi | Singh R.B.,The TsimTsoum Institute | Gupta S.,The TsimTsoum Institute | Dherange P.,The TsimTsoum Institute | And 4 more authors.
Canadian Journal of Physiology and Pharmacology | Year: 2012

The impact of diet and environmental factors on genes concerned with epigenetic inheritance and the mechanism of evolution has grown significantly beyond the Modern Synthesis period. Epigenetic inheritance is the passing of phenotypic change to subsequent generations in ways that are outside the genetic code of DNA. Recently, polymorphisms of the human Delta-5 (fatty acid desaturase, FADS1) and Delta-6 (FADS2) desaturase genes have been described as being associated with the level of several long-chain n-3 and n-6 polyunsaturated fatty acids (PUFAs) in serum phospholipids. Increased consumption of refined starches and sugar increases the generation of superoxide anion in the tissues and free fatty acids (FFA) in the blood. There is an increased amount and activity of nuclear factor-κB (NF-κB), a transcriptional factor regulating the activity of at least 125 genes, most of which are pro-inflammatory. The consumption of glucose may be associated with an increase in 2 other pro-inflammatory transcription factors: activating protein-1 (AP-1), and early growth response protein-1 (Egr-1). AP-1 regulates the transcription of matrix metallo-proteinases and Egr-1 modulates the transcription of tissue factor and plasminogen activator inhibitor-1. It is possible that a complex set of factors, including nutritional factors, come into play during epigenetic inheritance.


Hristova K.,Sofia University | Singh R.B.,Halberg Hospital and Research Institute | Fedacko J.,Safaric University | Toda E.,Tokai University | And 6 more authors.
World Heart Journal | Year: 2013

Introduction. Recent evidence shows that chronic heart failure (CHF) is a major cause of morbidity and mortality. The prognosis in CHF may be dependent on cause, severity and presence of risk factors and drug therapy. In the present study, we examine the causes, risk factors, class and oxidative stress among CHF patients. Subjects and methods. Of 127 patients with CHF, 2 were excluded and the remaining 125 patients (Men 61, women 64) with different aetiologies of CHF, and 250 age and sex matched control subjects, were evaluated in this case study. Severity of disease based on the New York Heart Association (NYHA) standards fell within functional classes II to IV. The diagnosis of HF was based on clinical manifestations as well as on echocardiographic heart enlargement. Results. The causes of CHF were; CAD (n=34, 27.2%), hypertensive heart disease (n=10, 8.0%),valvular heart disease (n=40, 32.0%) and idiopathic dilated cardiomyopathy (n=38, 30.4%).Risk factors of HF were; CAD (n=52, 41.6%), hypertension (>140/90mmHg) (n=54, 43.2%), diabetes mellitus (n=12, 9.6%), obesity (n=43, 34.4%) and albuminurea (n=12,9.6%). Echocardiographic ejection fraction was 39.1±8.2% (mean±SD)in the study group, indicating class II-IV heart failure. There was a significant increase in biomarkers of oxidative stress, among HF patients compared to healthy subjects. Conclusions. The findings indicate that HF has become a public health problem. The causes of HF appear to be CAD, cardiomyopathy and valvular heart disease. Severity of CHF, aetiology; CAD and cardiomyopathy appear to be important for increased oxidative stress among these patients. © Nova Science Publishers, Inc.


PubMed | The TsimTsoum Institute
Type: Journal Article | Journal: Canadian journal of physiology and pharmacology | Year: 2012

Recent research indicates an association between brain dysfunction and the pathogenesis of metabolic syndrome. To investigate this, we created a Medline search (up to December 2011) of articles in PubMed. The results indicated that refined carbohydrates, saturated and total fat, high levels of -6 fatty acids, and low levels of -3 fatty acids and other long chain polyunsaturated fatty acids (PUFA), all in conjunction with sedentary behaviour and mental stress can predispose to inflammation. Increased sympathetic activity, with increased secretion of catecholamine, cortisol, and serotonin can cause oxidative stress, which may damage the arcuate nucleus as well as the hypothalamus and macrophages, and the liver may release pro-inflammatory cytokines. These, in conjunction with an underlying deficiency in long chain PUFA, may damage the arcuate nucleus as well as neuropeptide-Y and pro-opiomelanocortin neurons and insulin receptors in the brain, especially during fetal life, infancy, and childhood, resulting in their dysfunction. Of the fatty acids in the brain, 30%-50% are long chain PUFA, which are incorporated in the cell membrane phospholipids. Hence, -3 fatty acids, which are also known to enhance parasympathetic activity and increase the secretion of anti-inflammatory cytokines interleukin (IL)-4 and IL-10 as well as acetylcholine in the hippocampus, may be protective. Therefore, treatment with -3 fatty acids may be applied for the prevention of metabolic syndrome.

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