Wang X.,The Third Peoples Hospital oj Zhengzhou |
Dong X.,The Third Peoples Hospital oj Zhengzhou |
Chen L.,The Third Peoples Hospital oj Zhengzhou |
Ma H.,The Third Peoples Hospital oj Zhengzhou |
And 4 more authors.
Journal of Leukemia and Lymphoma | Year: 2014
Objective To observe the therapeutic efficiency and associated complications of allogeneic hematopoietic stem cells transplantation (allo-HSCT) for treatment of 15 children with malignant hematological disease. Methods Fifteen children with malignant hematological disease were subjected to allo-HSCT from Jan 2007 to Jan 2013. Among those 15 patients, 13 cases were diagnosed as acute leukemina (AL), 1 case as chronic myeloid leukemia (CML), and 1 case as myelodysplastic syndrome (MDS-RAEB). The clinical characters of all cases after transplantation were analyzed, retrospectively. Results seven cases survived for 5 months to 6 years after transplantation. Five cases abandoned treatment because of relapse or severe infections. Three cases developed grade Ⅰ acute graft-versus-host disease (aGVHD), three cases developed grade Ⅱ, Ⅲ and Ⅳ aGVHD respectively, and one died of Ⅳ aGVHD. Two patients experienced extensive chronic graft-versus-host disease (cGVHD), one died of cGVHD, the other suffered it with poor quality of life. Conclusions Allo-HSCT is an efficient operation for the treatment of children with hematologic malignancies. Reduction of allo-HSCT associated complications is the first issue needs to be overcome, meanwhile, it is also important to understand the indications of children allo-HSCT. © 2014 Journal of Leukemia & Lymphoma.