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Zhang X.,Shandong University | Zhang Q.,The Third Peoples Hospital of Qingdao
Neurology Asia | Year: 2012

The association of spontaneous intracranial hypotension with cerebral venous sinus thrombosis is rare. We report here a case of extensive cerebral venous sinus thrombosis involving three sinuses following spontaneous intracranial hypotension. The patient presented no other thrombotic risk factors except for spontaneous intracranial hypotension. This case adds to the evidence that spontaneous intracranial hypotension is a risk factor for cerebral venous sinus thrombosis. Source


Wang L.-D.,Taishan Medical University | Gao X.,Binzhou Peoples Hospital | Li J.-Y.,Binzhou Peoples Hospital | Yu H.-Y.,The Third Peoples Hospital of Qingdao | And 3 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2015

Background: To investigate the effects of preemptive analgesia with parecoxib sodium on haemodynamics and plasma stress hormones in surgical patients with thyroid carcinoma. Materials and Methods: Fifty-seven patients with thyroid carcinoma who underwent thyroidectomy selectively in Laiwu Hospital Affiliated to Taishan Medical University and Binzhou People's Hospital were selected and randomly divided into three groups, 19 cases in each group. The control group was intravenously injected 0.9% sodium chloride injection before anesthesia induction; trial group I was intravenously injected with parecoxib sodium 20 min before anesthesia induction; based on trial group I, trial group II was injected with parecoxib sodium again 12 h after surgery. The levels of plasma norepinephrine (NE), cortisol (Cor) and blood glucose before, 12 and 24 h after surgery and changes of haemodynamics before surgery, at the end of surgery and 12, 24 and 48 h after surgery were compared in the three groups. Besides, visual analogue scale (VAS) scores were recorded 4, 8, 12 and 24 h after surgery. Results: 12 and 24 h after surgery, the levels of plasma NE and Cor in three groups rose dramatically (P<0.05 or (P<0.01); The levels of plasma NE and Cor in trial groups I and II were evidently lower than in control group (P<0.05 or P<0.01), and those in trial group II slightly lower than in trial group I. 12 h after surgery, the heart rates (HR) and systolic pressures (SBP) in trial groups I and II increased obviously by comparison to surgery before (P<0.05 or P<0.01), but gradually returned to the preoperative level. HR, SBP and diastolic pressures (DBP) in trial groups I and II at the end of surgery and 12 h after surgery were all lower than in the control group, and significant differences were present (P<0.05 or (P<0.01). At 4, 8, 12 and 24 h after surgery, VAS scores in trial groups I and II were markedly lower than in the control group ((P<0.05 or (P<0.01), the scores in trial group II being the lowest. Conclusions: Combined application of parecoxib sodium for preemptive analgesia before anesthesia and after surgery can effectively reduce the levels of plasma stress hormones and improve analgesic effects in surgical patients with thyroid carcinoma, and without conspicuous impact on haemodynamics. Source


Guo C.,Qingdao Municiple Hospital | Chen G.,The Third Peoples Hospital of Qingdao | Ge R.,Qingdao University
Molecular Immunology | Year: 2015

Interleukin-23 (IL-23) and IL-17 are involved in the pathogenesis of allergic rhinitis (AR). However, the roles of IL-23 and IL-17 in ovalbumin (OVA)-induced AR remain unclear. Therefore in this study we aim to investigate the precise roles of IL-23 and IL-17 in a mouse model of OVA-induced AR. We found that during OVA-induced AR, eosinophil and goblet cells in the nose were significantly decreased in IL-23-deficient, but not in IL-17-deficient mice. However, there was no difference in the serum IgE and IgG1 levels between IL-23-deficient or IL-17-deficient and wild-type mice. Moreover, IL-4 levels in lymph node cell culture supernatants were significantly decreased in IL-23-deficient, but not IL-17-deficient, compared with wild-type mice. Furthermore, OVA-induced AR developed similarly in wild-type mice transferred with either IL-23-deficient BM cells or wild-type BM cells. These findings suggest that IL-23, but not IL-17 is crucial for the development of OVA-induced AR, and IL-23 neutralization may be a potential approach for treatment of OVA-induced AR in humans. © 2015 Elsevier Ltd. Source


Liu W.-W.,The Third Peoples Hospital of Qingdao | Yu X.-H.,The Third Peoples Hospital of Qingdao
Chinese Journal of Ophthalmology | Year: 2012

Objective: To explore the clinical and pathological features of conjunctival myxoma and angiomyxoma. Methods: It was a retrospective case series study. The clinical and pathological features of 3 cases of conjunctival myxoma and 2 cases of conjunctival angiomyxoma were analyzed. These cases were treated from January 2005 to December 2010 at Tianjin Eye Hospital. Routine pathological examinations and immunohistochemical staining were performed, including staining for Vimentin, S-100, SMA and CD34. Results: In the 5 patients, 2 cases were male and 3 cases were female. The mean age was (55.8 ± 14.8) years, ranging from 40 to 74 years. The tumors presented as yellow-pink, translucent, cystic and (or) with solid masses. Regarding the tumor location, 2 cases involved the temporal side, 1 case involved the nasal side, 1 case involved the nasal limbus and invaded the cornea, and 1 case involved the nasal, temporal and inferior parts. The lesions of the 5 cases were excised under local anaesthesia. Histopathological examination revealed that the conjunctival myxomas were composed of abundant mucoid material and relatively small numbers of small, ovoid, spindle and stellate shaped cells with sparse vessels. The histologic features of the conjunctival angiomyxoma were similar to those of myxomas with the exception of the former being characterized by a prominent vascular structure. The immunohistochemical staining showed that tumor cells were positive for Vimentin, but negative for S-100 protein: some tumor cells were positive for CD34 and SMA. The follow-up was performed in 4 cases post-operation. One case experienced recurrence 1 month after surgical excision. Conclusions: Most of the conjunctival myxoma and angiomyxoma appear as a local yellow-pink, translucent, cystic and (or) with solid mass, and some of which had multiple tumors. The preferred management route is complete surgical excision. Copyright © 2010 by the Chinese Medical Association. Source


Wang J.-L.,Shandong University | Wang J.-L.,Qingdao University | Wu D.-W.,Shandong University | Cheng Z.-Z.,Qingdao University | And 3 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2014

Objective: This study evaluated the expression level of high mobility group box-B1 (HMGB-1) and matrix metalloproteinase-9 (MMP-9) in non-small cell lung cancer (NSCLC) inmorder to reveal any relation with development and prognosis. Methods: NSCLC and normal tissues were selected from 30 patients at age of 30- 73, and used for RT-PCR and Western blot analyses of HMGB-1. A total of 100 paraffin embedded NSCLC tissues were also isolated from patients through surgical resection, and used for detection of HMGB-1 byimmunohistochemistry. In addition, 50 samples were also applied for MMP-9 detection, and 30 normal tissues were considered as controls. Correlation analysis of HMGB-1 and MMP-9 was carried out by Pearsons correlation coefficient. Results: The average expression level of HMGB-1 in NSCLC patients was significantly higher than in normal lung tissues. In addition, patients in III-IV period exhibit significantly higher positive rate of HMGB- 1 when compared with I-II period cases. Furthermore, a positive correlation with HMGB-1 was found in the expression of MPP-9. Conclusion: HMGB-1 was highly expressed in NSCLC, which may become a prognostic and predictive marker for NSCLC. Besides, MPP-9 was positively correlated with HMGB-1. Source

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