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Mu J.-H.,The Third Peoples Hospital of Luoyang
International Eye Science | Year: 2013

AIM: To explore the clinical curative effect of laser photocoagulation for macular edema. METHODS: Krypton laser photocoagulation was applied for 42 patients (72 eyes) with macular edema, the situation of patients edema disapperance and vision improvement were observed 3 months after photocoagulation. RESULTS: Before treatment, the average visual acuity was 0.42 ±0.20, three months after treatment, the average visual acuity was 0.55 ±0.26, vision improvement rate was 93%; edema disappeared and the effective rate was 90%. CONCLUSION: The curative effect of krypton laser photocoagulation on macular edema is safe and stable.


Wang Z.-J.,The Third Peoples Hospital of Luoyang | Li J.-B.,The Third Peoples Hospital of Luoyang
International Eye Science | Year: 2012

AIM: To observe the safety and efficacy of phacoemulsification combined with silicone oil removal and intraocular lens implantation on the cataractous eyes filled with silicone oil after vitrectomy. METHODS: Totally 32 patients (32 eyes) with complication of cataract when filled with silicone oil after vitrectomy were selected and operated by phacoemulsification combined with removal of silicone oil through pars plana incision and foldable intraocular lens implantation. And then, they were followed up for 3-18 months (average 9 months). RESULTS: The best-corrected visual acuity after surgery were as follows: 3 eyes were light perception to the counting fingers, 10 eyes were 0.02 to 0.1, 12 eyes were between 0.1 and 0.2, and 7 eyes were above or equal to 0.3. And no complications such as retinal detachment, corneal endothelial decompensation, intraocular lens shifted, silicone oil left and so on were observed. CONCLUSION: The operations of phacoemulsification combined with removal of silicone oil through pars plana incision and foldable intraocular lens implantation, treating complication of cataract in eyes filled with silicone oil after vitrectomy, are safe and effective.


Chang S.F.,Zhengzhou University | Li S.L.,The Third Peoples Hospital Of Luoyang | Yang B.,Zhengzhou University | Yao K.M.,The Third Peoples Hospital Of Luoyang | And 3 more authors.
Genetics and Molecular Research | Year: 2015

Previous studies have demonstrated that the CXCL12 G801A polymorphism is closely correlated with tumor susceptibility. In addition, the CXCL12/CXCR4 pathway is closely related to proliferation, metastasis, and invasion of glioma. However, the genetic effects of the CXCL12 G801A polymorphism on glioma risk in Chinese populations remain unknown. In this study, we investigated the potential associations between the CXCL12 G801A polymorphism with glioma susceptibility and its clinicopathological characteristics. Frequencies of CXCL12 G801A polymorphic variants between glioma patients (N = 750) and healthy controls (N = 750) were assessed using restriction length fragment polymorphism analysis. The association among the CXCL12 G801A polymorphism, glioma grade (WHO classification), and histological type was also evaluated. Our results showed that patients with glioma had significantly higher frequency of the CXCL12-3' A/A genotypes (P = 0.039) as compared with healthy controls. When stratified by the glioma histology, high-grade glioma patients had significantly higher frequency of the CXCL12-3' A/A genotypes (P = 0.019) as compared with low-grade glioma patients. When stratified by the WHO grade, significantly higher frequency of the CXCL12-3' A/A genotype was observed in stage IV glioma patients (P = 0.037). We conclude that the CXCL12 G801A polymorphism is a risk factor that increases susceptibility to gliomas in a subset of the general Han Chinese population. © FUNPEC-RP.


PubMed | Zhengzhou University and The Third Peoples Hospital of Luoyang
Type: Journal Article | Journal: Genetics and molecular research : GMR | Year: 2016

Previous studies have demonstrated that the CXCL12 G801A polymorphism is closely correlated with tumor susceptibility. In addition, the CXCL12/CXCR4 pathway is closely related to proliferation, metastasis, and invasion of glioma. However, the genetic effects of the CXCL12 G801A polymorphism on glioma risk in Chinese populations remain unknown. In this study, we investigated the potential associations between the CXCL12 G801A polymorphism with glioma susceptibility and its clinicopathological characteristics. Frequencies of CXCL12 G801A polymorphic variants between glioma patients (N = 750) and healthy controls (N = 750) were assessed using restriction length fragment polymorphism analysis. The association among the CXCL12 G801A polymorphism, glioma grade (WHO classification), and histological type was also evaluated. Our results showed that patients with glioma had significantly higher frequency of the CXCL12-3 A/A genotypes (P = 0.039) as compared with healthy controls. When stratified by the glioma histology, high-grade glioma patients had significantly higher frequency of the CXCL12-3 A/A genotypes (P = 0.019) as compared with low-grade glioma patients. When stratified by the WHO grade, significantly higher frequency of the CXCL12-3 A/A genotype was observed in stage IV glioma patients (P = 0.037). We conclude that the CXCL12 G801A polymorphism is a risk factor that increases susceptibility to gliomas in a subset of the general Han Chinese population.

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