Time filter

Source Type

Zhou L.,Sun Yat Sen University | Cui M.-Y.,Sun Yat Sen University | Xiong J.,The Third Peoples Hospital of Dongguan City | Dong Z.,Sun Yat Sen University | And 6 more authors.
BMC Gastroenterology | Year: 2015

Background: This study aims to analyze the computed tomography (CT) and magnetic resonance imaging(MRI) characteristics of hepatic epithelioid hemangioendothelioma (HEHE). Methods: Eleven patients with histopathologically confirmed HEHE via surgical excision or biopsy were included. Imaging findings of these 11 patients were retrospectively analyzed (CT images obtained from all patients and MR images from five patients). Patterns of growth, characteristics of distribution, density/signal features, patterns of contrast enhancement, and changes of adjacent tissues were evaluated. Results: HEHE is characterized by multiple lesions in the liver. HEHE could be further categorized as three types when considering patterns of growth: nodular type(5 cases), coalescent type(1 case) and mixed type(5 cases). In this study, a total of 312 lesions were detected, 214(74.3 %) of which were subcapsular. All lesions appeared as hypodense while round lower density were found within 10 lesions(<2 cm) on unenhanced CT images. On MRI, all lesions demonstrated low signal intensity on T1 weighted images and high heterogeneous signal intensity on T2 weighted images when compared to the normal liver parenchyma. Other imaging features included "lollipop sign"(6 cases) and capsular retraction(6 cases). On contrast-enhanced CT and MRI, lesions smaller than 2.0 cm mostly showed mild homogeneous enhancement (214/227, 94.3 %); lesions measuring 2.0-3.0 cm in diameter showed ring-like enhancement (16/53,30.2 %) and heterogeneous delayed enhancement (29/53,54.7 %); lesions larger than 3.0 cm demonstrated heterogeneous delayed enhancement (26/32, 81.3 %). Conclusion: The imaging findings of HEHE showed some typical imaging features and size-dependent patterns with contrast enhancement on both CT and MR images, these features can be used for accurate imaging diagnosis of HEHE. © 2015 Zhou et al.


PubMed | The Third Peoples Hospital of Dongguan City, University of Western Australia and Sun Yat Sen University
Type: | Journal: BMC gastroenterology | Year: 2015

This study aims to analyze the computed tomography (CT) and magnetic resonance imaging(MRI) characteristics of hepatic epithelioid hemangioendothelioma (HEHE).Eleven patients with histopathologically confirmed HEHE via surgical excision or biopsy were included. Imaging findings of these 11 patients were retrospectively analyzed (CT images obtained from all patients and MR images from five patients). Patterns of growth, characteristics of distribution, density/signal features, patterns of contrast enhancement, and changes of adjacent tissues were evaluated.HEHE is characterized by multiple lesions in the liver. HEHE could be further categorized as three types when considering patterns of growth: nodular type(5 cases), coalescent type(1 case) and mixed type(5 cases). In this study, a total of 312 lesions were detected, 214(74.3%) of which were subcapsular. All lesions appeared as hypodense while round lower density were found within 10 lesions(<2 cm) on unenhanced CT images. On MRI, all lesions demonstrated low signal intensity on T1 weighted images and high heterogeneous signal intensity on T2 weighted images when compared to the normal liver parenchyma. Other imaging features included lollipop sign(6 cases) and capsular retraction(6 cases). On contrast-enhanced CT and MRI, lesions smaller than 2.0 cm mostly showed mild homogeneous enhancement (214/227, 94.3%); lesions measuring 2.0-3.0 cm in diameter showed ring-like enhancement (16/53,30.2%) and heterogeneous delayed enhancement (29/53,54.7%); lesions larger than 3.0 cm demonstrated heterogeneous delayed enhancement (26/32, 81.3%).The imaging findings of HEHE showed some typical imaging features and size-dependent patterns with contrast enhancement on both CT and MR images, these features can be used for accurate imaging diagnosis of HEHE.


PubMed | The Third Peoples Hospital of Dongguan City and Sun Yat Sen University
Type: | Journal: Journal of diabetes investigation | Year: 2016

Angiotensin-(1-7) [Ang-(1-7)], recognized as a new bioactive peptide in renin-angiotensinsystem (RAS), shows biological and pharmacological properties in diabetic cardiovascular diseases. Leptin induced-p38 MAPK pathway has been reported to contribute to the high glucose (HG)-induced injury. In this study, we demonstrated the mechanism that how Ang-(1-7) can protect from HG-stimulated injuries in H9c2 cells.H9c2 cells were treated with 35 mM glucose (HG) for 24 h to establish a model of HG-induced damage. Apoptotic cells were observed by Hoechst 33258 staining. Cell viability was analyzed by cell counter kit-8, The expression of protein was detected by Western blot. ROS was tested by DCFH-DA staining. MMP was measured by JC-1 staining.Our results revealed that treating H9c2 cells with HG obviously enhanced the expressions of both leptin and phosphorylated (p)-MAPK pathway. However, the over-expression levels of leptin and p-p38 MAPK/p-ERK1/2 but not p-JNK were significantly suppressed by treatment of the cells with Ang-(1-7). Additionally, LA (leptin antagonist) also markedly suppressed the over-expressions of p38 and ERK1/2 induced by HG while LA had no influence on the over-expression of JNK. More remarkable, Ang-(1-7), LA, SB203580, or SP600125, respectively, significantly inhibited the injuries induced by HG, such as the increased cell viability, decreased apoptotic rate, reduction of ROS production, and increased MMP. Furthermore, the over-expressions of p38 MAPK, ERK1/2 and leptin were suppressed by NAC.Our findings demonstrate that Ang-(1-7) protects from HG-stimulated damages as an inhibitor of the ROS-leptin-p38 MAPK/ ERK1/2 pathways but not leptin-JNK pathway in vitro. This article is protected by copyright. All rights reserved.


Yang Y.-F.,The Third Peoples Hospital Of Dongguan City | Liao Y.-Y.,Guangxi Medical University | Yang M.,The Third Peoples Hospital Of Dongguan City | Peng N.-F.,Guangxi Medical University | And 2 more authors.
Medical Oncology | Year: 2014

The aim of this study was to evaluate the frequency and prognostic impact of changes in the estrogen (ER), progesterone (PR) and human epidermal growth factor receptor 2 (HER2) status between primary and recurrent/metastatic lesions (RML). We investigated 133 breast cancer patients for ER, PR and HER2 status of primary and RML and their follow-up records. Among 133 patients with RML, discordance rate for ER, PR, and HER2 was 18.8, 33.8, and 6.8 %, respectively. ER, PR and HER2 discordance were observed in 20.0, 38.1 and 6.7 % of the patients with distant metastasis, and in 14.3, 17.9 and 7.1 % of the patients with locoregional recurrence. The mean time between the primary diagnosis and last contact or death was 57 (range 22–78) months and between the recurrence biopsy and last contact or death was 17 (range 1–33) months. Among 133 patients with RML, the ER-discordant cases and ER-loss cases experienced a worse overall survival (OS) (p = 0.001 and p = 0.016, respectively) and post-recurrence survival (PRS) (p = 0.001 and p = 0.018, respectively), compared with the respective concordant cases. The HER2-discordant patients and HER2-loss patients had a poorer OS (p = 0.008 and p = 0.001, respectively) and PRS (p = 0.004 and p = 0.000, respectively) than the respective concordant cases. Among 105 patients with distant metastasis, ER discordance, ER loss, HER2 discordance and HER2 loss, compared with the respective concordant cases, resulted in a worse OS and PRS (p < 0.05 for all). Our findings show an evident change in ER, PR and HER2 between breast primary tumors and relapsing tumors. The unstable status for ER or HER2 in breast cancer seems to be clinically significant and to correlate with a worse prognosis. © 2014, Springer Science+Business Media New York.


You Q.,Guangdong Medical College | Wu Z.,Guangdong Medical College | Wu B.,Guangdong Medical College | Liu C.,Guangdong Medical College | And 5 more authors.
Journal of Endocrinology | Year: 2016

We previously reported that naringin (NRG) protects cardiomyocytes against high glucose (HG)-induced injuries by inhibiting the MAPK pathway. The aim of this study was to test the hypothesis that NRG prevents cardiomyocytes from hyperglycemia-induced insult through the inhibition of the nuclear factor kappa B (NF-κB) pathway and the upregulation of ATP-sensitive K+ (KATP) channels. Our results showed that exposure of cardiomyocytes to HG for 24 h markedly induced injuries, as evidenced by a decrease in cell viability and oxidative stress, and increases in apoptotic cells as well as the dissipation of mitochondrial membrane potential (MMP). These injuries were markedly attenuated by the pretreatment of cells with either NRG or pyrrolidine dithiocarbamate (PDTC) before exposure to HG. Furthermore, in streptozotocin (STZ)-induced diabetic rats and in HG-induced cardiomyocytes, the expression levels of caspase-3, bax and phosphorylated (p)-NF-κB p65 were increased. The increased protein levels were ameliorated by pretreatment with both NRG and PDTC. However, the expression levels of bcl-2 and KATP and superoxide dismutase (SOD) activity were decreased by hyperglycemia; the expression level of Nox4 and the ADP/ATP ratio were increased by hyperglycemia. These hyperglycemia-induced indexes were inhibited by the pretreatment of cardiomyocytes with NRG or PDTC. In addition, in STZ-induced diabetic rats, we also observed that NRG or PDTC contributed to protecting mitochondrial injury and myocardium damage. This study demonstrated that NRG protects cardiomyocytes against hyperglycemia-induced injury by upregulating KATP channels in vitro and inhibiting the NF-κB pathway in vivo and in vitro. © 2016 Society for Endocrinology.


Yang Y.-F.,The Third Peoples Hospital of Dongguan City | Liao Y.-Y.,The Third Peoples Hospital of Dongguan City | Yang M.,The Third Peoples Hospital of Dongguan City | Peng N.-F.,The Third Peoples Hospital of Dongguan City | And 2 more authors.
Medical oncology (Northwood, London, England) | Year: 2014

The aim of this study was to evaluate the frequency and prognostic impact of changes in the estrogen (ER), progesterone (PR) and human epidermal growth factor receptor 2 (HER2) status between primary and recurrent/metastatic lesions (RML). We investigated 133 breast cancer patients for ER, PR and HER2 status of primary and RML and their follow-up records. Among 133 patients with RML, discordance rate for ER, PR, and HER2 was 18.8, 33.8, and 6.8%, respectively. ER, PR and HER2 discordance were observed in 20.0, 38.1 and 6.7% of the patients with distant metastasis, and in 14.3, 17.9 and 7.1% of the patients with locoregional recurrence. The mean time between the primary diagnosis and last contact or death was 57 (range 22-78) months and between the recurrence biopsy and last contact or death was 17 (range 1-33) months. Among 133 patients with RML, the ER-discordant cases and ER-loss cases experienced a worse overall survival (OS) (p=0.001 and p=0.016, respectively) and post-recurrence survival (PRS) (p=0.001 and p=0.018, respectively), compared with the respective concordant cases. The HER2-discordant patients and HER2-loss patients had a poorer OS (p=0.008 and p=0.001, respectively) and PRS (p=0.004 and p=0.000, respectively) than the respective concordant cases. Among 105 patients with distant metastasis, ER discordance, ER loss, HER2 discordance and HER2 loss, compared with the respective concordant cases, resulted in a worse OS and PRS (p<0.05 for all). Our findings show an evident change in ER, PR and HER2 between breast primary tumors and relapsing tumors. The unstable status for ER or HER2 in breast cancer seems to be clinically significant and to correlate with a worse prognosis.

Loading The Third Peoples Hospital of Dongguan City collaborators
Loading The Third Peoples Hospital of Dongguan City collaborators